Breathe Well Live Well
Conditions: Asthma; Pulmonary Disease, Chronic Obstructive
Intervention:
Sponsors: University of Leicester; University Hospitals, Leicester
Recruiting – verified August 2016
View full post on ClinicalTrials.gov: asthma | Studies received in the last 14 days
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Related Articles |
Epigenetic Dysfunction in Turner Syndrome Immune Cells.
Curr Allergy Asthma Rep. 2016 May;16(5):36
Authors: Thrasher BJ, Hong LK, Whitmire JK, Su MA
Abstract
Turner syndrome (TS) is a chromosomal condition associated with partial or complete absence of the X chromosome that involves characteristic findings in multiple organ systems. In addition to well-known clinical characteristics such as short stature and gonadal failure, TS is also associated with T cell immune alterations and chronic otitis media, suggestive of a possible immune deficiency. Recently, ubiquitously transcribed tetratricopeptide repeat on the X chromosome (UTX), a histone H3 lysine 27 (H3K27) demethylase, has been identified as a downregulated gene in TS immune cells. Importantly, UTX is an X-linked gene that escapes X-chromosome inactivation and thus is haploinsufficient in TS. Mice with T cell-specific UTX deficiency have impaired clearance of chronic viral infection due to decreased frequencies of T follicular helper (Tfh) cells, which are critical for B cell antibody generation. In parallel, TS patients have decreased Tfh frequencies in peripheral blood. Together, these findings suggest that haploinsufficiency of the X-linked UTX gene in TS T cells underlies an immune deficit, which may manifest as increased predisposition to chronic otitis media.
PMID: 27039394 [PubMed – in process]
View full post on pubmed: asthma
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NOX4 expression linked to ciliary dysfunction in asthma patients
Healio Researchers observed a correlation between NOX4 expression and reactive oxygen species generation in bronchial epithelial cells taken from asthmatic patients, which increased the risk for ciliary dysfunction, according to data recently published in Chest. |
View full post on asthma – Google News
Condition: ASTHMA
Interventions: Genetic: asthma with proximal airways obstruction phenotype profile description with clinical, biological, morphologic and genetic elements.; Genetic: asthma with small airways dysfunction phenotype profile description with clinical, biological, morphologic and genetic elements.
Sponsor: Hospices Civils de Lyon
Not yet recruiting – verified October 2015
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
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In refractory asthma, think vocal cord dysfunction
Family Practice News Digital Network “Vocal cord dysfunction is an important diagnosis. It's something to think about in your toughest-to-treat asthma patients. I think you'll see a lot of it,” Dr. Robert L. Keith predicted at a conference on internal medicine sponsored by the University … |
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Comparison of temporal transcriptomic profiles from immature lungs of two rat strains reveals a viral response signature associated with chronic lung dysfunction.
PLoS One. 2014;9(12):e112997
Authors: Hines EA, Szakaly RJ, Leng N, Webster AT, Verheyden JM, Lashua AJ, Kendziorski C, Rosenthal LA, Gern JE, Sorkness RL, Sun X, Lemanske RF
Abstract
Early life respiratory viral infections and atopic characteristics are significant risk factors for the development of childhood asthma. It is hypothesized that repeated respiratory viral infections might induce structural remodeling by interfering with the normal process of lung maturation; however, the specific molecular processes that underlie these pathological changes are not understood. To investigate the molecular basis for these changes, we used an established Sendai virus infection model in weanling rats to compare the post-infection transcriptomes of an atopic asthma susceptible strain, Brown Norway, and a non-atopic asthma resistant strain, Fischer 344. Specific to this weanling infection model and not described in adult infection models, Sendai virus in the susceptible, but not the resistant strain, results in morphological abnormalities in distal airways that persist into adulthood. Gene expression data from infected and control lungs across five time points indicated that specific features of the immune response following viral infection were heightened and prolonged in lungs from Brown Norway rats compared with Fischer 344 rats. These features included an increase in macrophage cell number and related gene expression, which then transitioned to an increase in mast cell number and related gene expression. In contrast, infected Fischer F344 lungs exhibited more efficient restoration of the airway epithelial morphology, with transient appearance of basal cell pods near distal airways. Together, these findings indicate that the pronounced macrophage and mast cell responses and abnormal re-epithelialization precede the structural defects that developed and persisted in Brown Norway, but not Fischer 344 lungs.
PMID: 25437859 [PubMed – in process]
View full post on pubmed: asthma
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Vocal cord dysfunction, asthma shared similar symptoms
Healio Patients with vocal cord dysfunction and asthma were affected by common risk factors and exhibited similar symptoms, according to recent study results. “Vocal fold motion disorder, also known as vocal cord dysfunction (VCD), is a disorder caused by … |
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Vocal Cord Dysfunction Is a Puzzling Asthma Mimic
JEMS.com The next day, when dropping off a patient at the same ED, you're puzzled to find out the girl was diagnosed with exercise-induced asthma. She was prescribed albuterol and told to use a vaporizer with eucalyptus ointment to promote bronchodilation … |
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Breathing distress from vocal cord dysfunction may co-exist with asthma
St. Louis American Notice these symptoms did not involve the chest, as in asthma, which involves airway inflammation. These symptoms are centered in the upper airway, a clue that it may involve something seemingly unrelated to the lungs. Vocal cords vibrate air to make … |
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Vocal Cord Dysfunction Often Mistaken for Asthma in Athletes
Lincoln Journal Star Some athletes may have both asthma and VCD. People with VCD may have extreme episodes of breathing difficulty in only isolated situations, such as competitive sports or exercise, whereas athletes with exercise-induced asthma will usually exhibit … |
View full post on asthma – Google News