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Genes and Early Wheezing Tied to Childhood Asthma Risk
U.S. News & World Report These children, all from families with a history of asthma or allergies, were nearly four times more likely to develop asthma than those who did not have the genetic variation and did not wheeze, according the study in the March 28 issue of the New … |
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 Times of India |
Pollen exposure during late pregnancy increases risk of early asthma in child …
News-Medical.net A woman's exposure to high pollen levels in late pregnancy increases the risk of early asthma in the child, according to a group of researchers at Sweden's Ume- University in a recent study. A number of studies have previously shown that there is an … Pollen linked to child's asthma risk |
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 Sky News Australia |
Woman's exposure to pollen in late pregnancy increases risk of early asthma in …
News-Medical.net A woman's exposure to high pollen levels in late pregnancy increases the risk of early asthma in the child, according to a group of researchers at Sweden's Ume- University in a recent study. A number of studies have previously shown that there is an … Pollen link to baby asthma link |
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Pollen Exposure During Pregnancy Affects Child's Risk of Early Asthma, Study …
Science Daily (press release) The researchers note that high levels of pollen exposure during the last 12 weeks of pregnancy resulted in a significantly increased risk of hospitalization for asthma symptoms in the first year of life for a child. The analysis was adjusted for … |
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Pollen exposure during pregnancy affects child's risk of early asthma
EurekAlert (press release) A woman's exposure to high pollen levels in late pregnancy increases the risk of early asthma in the child, according to a group of researchers at Sweden's Umeå University in a recent study. A number of studies have previously shown that there is an … |
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The relationship between antibiotic therapy in early childhood and the symptoms of allergy in children aged 6-8 years – the questionnaire study results.
Int J Occup Med Environ Health. 2012 Dec 3;
Authors: Raciborski F, Tomaszewska A, Komorowski J, Samel-Kowalik P, Bia?oszewski AZ, Artur W, Lusawa A, Szyma?ski J, Opoczy?ska D, Dru?ba M, Borowicz J, Lipiec A, Kapalczynski WJ, Samoli?ski B
Abstract
INTRODUCTION: Studies based on the ISAAC questionnaire suggest a correlation between the use of antibiotics and the prevalence of asthma and allergy in children aged 6-7 years. The number of courses of antibiotic therapy is an important factor. OBJECTIVES: To investigate the relationship between the use of antibiotics during the first years of life and the prevalence of allergy and asthma among children (aged 6-8 years) in the urban population of Poland. MATERIALS AND METHODS: A survey-based study with a self-completed questionnaire. The respondents were parents of children aged 6-8 years living in Warszawa, Poland. 1461 completed questionnaires were collected. RESULTS: Asthma was declared in 4.3% of the children. Wheezing and/or sibilant rhonchi within 12 months before the study was observed in 13.5% of the cases. Asthma medication was taken by 21.8% of the children. Allergic rhinitis was declared in 18.7% of the children. Problems with sneezing, rhinorrhea, and nasal congestion not associated with cold or fever were observed in 40.7% of the children. The analysis of the odds ratios between the use of antibiotics and the symptoms of allergic diseases revealed a clear correlation. The highest odds ratio was observed between the completion of over three courses of antibiotic therapy prior to the age of 12 months and the declaration of one of the following: asthma (OR = 5.59, 95% CI: 2.6-12.01), wheezing and/or sibilant rhonchi (OR = 4.68, 95% CI: 3.01-7.27) and taking medicines for breathlessness (OR = 5.12, 95% CI: 3.42-7.68). CONCLUSIONS: There is a direct relationship between antibiotic use in the first 3 years of life and asthma and allergy symptoms in children aged 6-8 years old.
PMID: 23212289 [PubMed – as supplied by publisher]
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Identifying infants at high risk of peanut allergy: The Learning Early About Peanut Allergy (LEAP) screening study.
J Allergy Clin Immunol. 2012 Nov 19;
Authors: Du Toit G, Roberts G, Sayre PH, Plaut M, Bahnson HT, Mitchell H, Radulovic S, Chan S, Fox A, Turcanu V, Lack G, Learning Early About Peanut Allergy (LEAP) Study Team
Abstract
BACKGROUND: Peanut allergy (PA) is rare in countries in which peanuts are introduced early into infants’ diets. Learning Early About Peanut Allergy (LEAP) is an interventional study aiming to assess whether PA can be prevented by oral tolerance induction. OBJECTIVE: We sought to characterize a population screened for the risk of PA. METHODS: Subjects screened for the LEAP interventional trial comprise the LEAP screening study cohort. Infants were aged 4 to 10 months and passed a prescreening questionnaire. RESULTS: This analysis includes 834 infants (mean age, 7.8 months). They were split into the following: group I, patients with mild eczema and no egg allergy (n = 118); group II, patients with severe eczema, egg allergy, or both but 0-mm peanut skin prick test (SPT) wheal responses (n = 542); group III, patients with severe eczema, egg allergy, or both and 1- to 4-mm peanut wheal responses (n = 98); and group IV, patients with greater than 4-mm peanut wheal responses (n = 76). Unexpectedly, many (17%) in group II had peanut-specific IgE sensitization (?0.35 kU/L); 56% of group III were similarly sensitized. In contrast, none of the patients in group I and 91% of those in group IV had peanut-specific IgE sensitization. Sensitization on skin testing to peanut (SPT response of 1-4 mm vs 0 mm) was associated with egg allergy and severe eczema (odds ratio [OR], 2.31 [95% CI, 1.39-3.86] and 2.47 [95% CI, 1.14-5.34], respectively). Similar associations were observed with specific IgE sensitization. Black race was associated with a significantly higher risk of peanut-specific IgE sensitization (OR, 5.30 [95% CI, 2.85-9.86]). Paradoxically, for a given specific IgE level, black race was protective against cutaneous sensitization (OR, 0.15 [95% CI, 0.04-0.61]). CONCLUSION: Egg allergy, severe eczema, or both appear to be useful criteria for identifying high-risk infants with an intermediate level of peanut sensitization for entry into a PA prevention study. The relationship between specific IgE level and SPT sensitization needs to be considered within the context of race.
PMID: 23174658 [PubMed – as supplied by publisher]
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 MedPage Today |
Early Signal Ignored?
MedPage Today In that 16-week trial of 25,000 asthma patients, 12 people randomized to salmeterol died of asthma and respiratory causes, versus two in the control group who took a standard medication, according to results published in 1993.. In addition, there were … Side Effects | A Journal Sentinel Watchdog Report |
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1990s trial gave early danger signs for asthma drugs
Milwaukee Journal Sentinel The troubled history of asthma drugs known as long-acting beta-agonists goes back to the 1990s when a large clinical trial in Great Britain of the GlaxoSmithKline drug Serevent produced disturbing results. In that 16-week trial of 25,000 asthma … |
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 Gothamist |
Early Addition: 1 In 8 NYC Kids Has Asthma, Report Says
Gothamist Early Addition: 1 In 8 NYC Kids Has Asthma, Report Says. 071812ker.jpg (Copyright Paul Ker). Follow Gothamist on Twitter and like us on Facebook. You can also get the top stories mailed to you—sign up here. 1 in 8 NYC kids have asthma, a new report … 'Dark Knight' first take: An epic worth seeing |
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