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 The Hindu |
Vitamin C can cut harmful effects of air pollution
The Hindu Researchers looked at London hospital patients with asthma or chronic obstructive pulmonary disease (COPD), and found that those with low levels of vitamin C had an increased risk of breathing problems on days when outdoor air pollution levels were high. Vitamin C reduces air pollution harmful effects on lungs |
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 Zee News |
Vitamin C can cut harmful effects of air pollution: Study
Zee News Researchers from Imperial College in London looked at patients with asthma or chronic obstructive pulmonary disease (COPD), and found that those with low levels of vitamin C had an increased risk of breathing problems when outdoor air pollution levels … |
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Vitamin C may lessen harmful effects of air pollution
NBCNews.com Researchers looked at London hospital patients with asthma or chronic obstructive pulmonary disease (COPD), and found that those with low levels of vitamin C had an increased risk of breathing problems on days when outdoor air pollution levels were high. |
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Anti-inflammatory and antinociceptive effects of salbutamol on acute and chronic models of inflammation in rats: involvement of an antioxidant mechanism.
Mediators Inflamm. 2012;2012:438912
Authors: Uzkeser H, Cadirci E, Halici Z, Odabasoglu F, Polat B, Yuksel TN, Ozaltin S, Atalay F
Abstract
The possible role of ?-2 adrenergic receptors in modulation of inflammatory and nociceptive conditions suggests that the ?-2 adrenergic receptor agonist, salbutamol, may have beneficial anti-inflammatory and analgesic effects. Therefore, in this study, we induced inflammatory and nociceptive responses with carrageenan-induced paw edema or cotton-pellet-induced granuloma models, both of which result in oxidative stress. We hypothesized that salbutamol would prevent inflammatory and nociceptive responses by stimulating ?-2 adrenergic receptors and the prevention of generation of ROS during the acute inflammation process in rats. Both doses of salbutamol used in the study (1 and 2?mg/kg) effectively blocked the acute inflammation and inflammatory nociception induced by carrageenan. In the cotton-pellet-induced granuloma test, both doses of salbutamol also significantly decreased the weight of granuloma tissue on the cotton pellets when compared to the control. Anti-inflammatory and analgesic effects of salbutamol were found to be comparable with those of indomethacin. Salbutamol decreased myeloperoxidase (MPO) activity and lipid peroxidation (LPO) level and increased the activity of superoxide dismutase (SOD) and level of glutathione (GSH) during the acute phase of inflammation. In conclusion, salbutamol can decrease acute and chronic inflammation, possibly through the stimulation of ?-2 adrenergic receptors. This anti-inflammatory effect may be of significance in asthma treatment, where inflammation also takes part in the etiopathology. This study reveals that salbutamol has significant antioxidative effects, which at least partially explain its anti-inflammatory capabilities. These findings presented here may also shed light on the roles of ?-2 adrenergic receptors in inflammatory and hyperalgesic conditions.
PMID: 22665951 [PubMed – in process]
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Warning on health effects of climate change
Irish Health By Gillian Tsoi The number of people around the world with asthma, allergies and other infectious diseases will increase as a result of rising temperatures, worsening ozone levels in urban areas and desertification (which causes fertile land to … Climate Change Heating Up Respiratory Diseases Lung doctors expect respiratory diseases will worsen with global climate change Doctors Warn Climate Change May Lead to Spike in Asthma Cases |
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Antiasthmatic Effects of Herbal Complex MA and Its Fermented Product MA128.
Evid Based Complement Alternat Med. 2012;2012:769508
Authors: Kim DS, Kim SH, Kim BK, Yang MC, Ma JY
Abstract
This study was conducted to determine if oral administration of the novel herbal medicine, MA, and its Lactobacillus acidophilus fermented product, MA128, have therapeutic properties for the treatment of asthma. Asthma was induced in BALB/c mice by systemic sensitization to ovalbumin (OVA) followed by intratracheal, intraperitoneal, and aerosol allergen challenges. MA and MA128 were orally administered 6 times a week for 4 weeks. At 1 day after the last ovalbumin exposure, airway hyperresponsiveness was assessed and samples of bronchoalveolar lavage fluid, lung cells, and serum were collected for further analysis. We investigated the effect of MA and MA128 on airway hyperresponsiveness, pulmonary eosinophilic infiltration, various immune cell phenotypes, Th2 cytokine production, OVA-specific IgE production, and Th1/Th2 cytokine production in this mouse model of asthma. In BALB/c mice, we found that MA and MA128 treatment suppressed eosinophil infiltration into airways and blood, allergic airway inflammation and AHR by suppressing the production of IL-5, IL-13, IL-17, Eotaxin, and OVA-specific IgE, by upregulating the production of OVA-specific Th1 cytokine (IFN-?), and by downregulating OVA-specific Th2 cytokine (IL-4) in the culture supernatant of spleen cells. The effectiveness of MA was increased by fermentation with Lactobacillus acidophilus.
PMID: 22203879 [PubMed – in process]
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Biological Clock May Affect Asthma Side Effects
dailyRx In fact, that process also impacts certain side effects in asthma and allergy medications. A new study found that the processes involved with the body's biological clock interact with hormones that are targeted by asthma and allergy drugs. … |
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UIC researchers test effects of vitamin D on asthma severity
PhysOrg.com Researchers at the University of Illinois at Chicago are recruiting volunteers with asthma for a study of whether taking vitamin D can make asthma medication more effective. The study is called VIDA (Vitamin D add-on therapy enhances corticosteroid … |
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UIC Researchers Test Effects of Vitamin D on Asthma Severity
NEWS.GNOM.ES (press release) Researchers at the University of Illinois at Chicago are recruiting volunteers with asthma for a study of whether taking vitamin D can make asthma medication more effective. The study is called VIDA (Vitamin D add-on therapy enhances corticosteroid … |
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Researchers Test Effects of Vitamin D on Asthma Severity
Newswise (press release) Newswise — Researchers at the University of Illinois at Chicago are recruiting volunteers with asthma for a study of whether taking vitamin D can make asthma medication more effective. The study is called VIDA (Vitamin D add-on therapy enhances … |
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