Breathe Well Live Well
Condition: Cow’s Milk Allergy
Intervention: Dietary Supplement: Extensively hydrolyzed casein formula plus LGG
Sponsor: Federico II University
Completed – verified May 2016
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Related Articles |
Epigenetic Dysfunction in Turner Syndrome Immune Cells.
Curr Allergy Asthma Rep. 2016 May;16(5):36
Authors: Thrasher BJ, Hong LK, Whitmire JK, Su MA
Abstract
Turner syndrome (TS) is a chromosomal condition associated with partial or complete absence of the X chromosome that involves characteristic findings in multiple organ systems. In addition to well-known clinical characteristics such as short stature and gonadal failure, TS is also associated with T cell immune alterations and chronic otitis media, suggestive of a possible immune deficiency. Recently, ubiquitously transcribed tetratricopeptide repeat on the X chromosome (UTX), a histone H3 lysine 27 (H3K27) demethylase, has been identified as a downregulated gene in TS immune cells. Importantly, UTX is an X-linked gene that escapes X-chromosome inactivation and thus is haploinsufficient in TS. Mice with T cell-specific UTX deficiency have impaired clearance of chronic viral infection due to decreased frequencies of T follicular helper (Tfh) cells, which are critical for B cell antibody generation. In parallel, TS patients have decreased Tfh frequencies in peripheral blood. Together, these findings suggest that haploinsufficiency of the X-linked UTX gene in TS T cells underlies an immune deficit, which may manifest as increased predisposition to chronic otitis media.
PMID: 27039394 [PubMed – in process]
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Drug Discovery & Development |
Epigenetic Study Finds Genes Involved in Allergies, Asthma
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Yahoo News UK |
Public Release: 18-Feb-2015 Epigenetic study highlights drug targets for …
EurekAlert (press release) Scientists have discovered over 30 new genes that predispose people to allergies and asthma, some of which could be targets for new drugs. Asthma affects one child in 10 in the UK, and allergies may affect one third of the population. The new findings … Epigenetic study highlights drug targets for allergies and asthma Researchers discover promising targets for treating allergies and asthma Gene research shows promise for asthma treatment |
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Laboratory Talk |
Epigenetic study highlights drug targets for allergies and asthma
Medical Xpress The researchers analysed white blood cells from families with asthma in the UK to see whether methylation levels in certain parts of the genome were correlated with the level of IgE in the blood. To be sure of their results, the researchers tested … Public Release: 18-Feb-2015 Epigenetic study highlights drug targets for … Researchers discover promising targets for treating allergies and asthma New hope for asthma and allergy sufferers |
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Air Pollutants Linked to Asthma-Related Epigenetic Changes
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View full post on asthma – Google News