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Researchers Say Evidence Lacking on Link Between Asthma and Exposure to …
Infection Control Today Researchers exploring the relationship between asthma and exposure to consumer products and product ingredients say the database of current studies is not sufficiently robust to demonstrate a causal relationship between product exposures and new-onset … |
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IL-13 exposure enhances vitamin D-mediated expression of the human cathelicidin antimicrobial peptide-hCAP18/LL-37 in bronchial epithelial cells.
Infect Immun. 2012 Oct 8;
Authors: Schrumpf JA, van Sterkenburg MA, Verhoosel RM, Zuyderduyn S, Hiemstra PS
Abstract
Vitamin D is an important regulator of the expression of antimicrobial peptides, and vitamin D deficiency is associated with respiratory infections. Regulating expression of antimicrobial peptides such as the human cathelicidin antimicrobial peptide (hCAP)18/LL-37 by vitamin D in bronchial epithelial cells requires local conversion of 25(OH)vitaminD(3) (25D(3)) into its bioactive metabolite 1,25(OH)(2)vitaminD(3) (1,25D(3)) by CYP27B1. Low circulating vitamin D-levels in childhood asthma are associated with more severe exacerbations, which are often associated with infections. Atopic asthma is accompanied by Th2 driven inflammation mediated by cytokines such as IL-4 and IL-13, and the effect of these cytokines on vitamin D metabolism and hCAP-18/LL-37 expression is unknown. Therefore we investigated this in well-differentiated bronchial epithelial cells. To this end, cells were treated with IL-13 with and without 25D(3) and expression of hCAP18/LL-37, CYP27B1, the 1,25D(3) inactivating enzyme CYP24A1, and vitamin D receptor was assessed by quantitative PCR. We show that IL-13 enhances the ability of 25D(3) to increase expression of hCAP18/LL-37 and CYP24A1. In addition, exposure to IL-13 resulted in increased CYP27B1 expression, whereas VDR expression was not significantly affected. The enhancing effect of IL-13 on 25D(3)-mediated expression of hCAP18/LL-37 was further confirmed using SDS-PAGE Western Blot and immunofluorescence staining. In conclusion, we demonstrate that IL-13 induces vitamin D(-)dependent hCAP18/LL-37 expression, most likely by increasing CYP27B1. These data suggest that Th2 cytokines regulate the vitamin D metabolic pathway in bronchial epithelial cells.
PMID: 23045480 [PubMed – as supplied by publisher]
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Occupational exposure to cleaning products and asthma in hospital workers.
Occup Environ Med. 2012 Oct 2;
Authors: Dumas O, Donnay C, Heederik DJ, Héry M, Choudat D, Kauffmann F, Le Moual N
Abstract
OBJECTIVE: Cleaning products may cause work-related asthma, but information regarding the specific exposures involved is scarce. We aimed to determine the associations between asthma and occupational exposure to cleaning agents in hospital workers. METHODS: Analyses were conducted in 179 (136 women) hospital workers and a reference population of 545 subjects (18-79 years) from the French case-control and familial Epidemiological study on the Genetics and Environment of Asthma (2003-2007). Exposures to cleaning agents were estimated using three methods: self-report, expert assessment and an asthma-specific job-exposure matrix (JEM). Associations between cleaning products and current asthma were evaluated by logistic regressions, stratified by sex and adjusted for age and smoking status. RESULTS: According to expert assessment, 55% of male and 81% of female hospital workers were exposed to cleaning/disinfecting tasks weekly (p<0.001). No association was observed between cleaning/disinfecting tasks and current asthma in men or in women whatever the assessment method used. In women, exposure to decalcifiers (expert assessment) was associated with current asthma (OR (95% CI):2.38 (1.06 to 5.33)). In hospital workers classified as exposed according to both the expert assessment and the JEM, additional associations were observed for exposure to ammonia (3.05 (1.19 to 7.82)) and to sprays with moderate/high intensity (2.87 (1.02 to 8.11)). CONCLUSIONS: Female hospital workers are often exposed to numerous cleaning products, some of which were markedly associated with current asthma. Low numbers prevented a meaningful analysis in men. Objective and more accurate estimates of occupational exposure to cleaning products are needed to better understand the adverse effects of cleaning products.
PMID: 23033509 [PubMed – as supplied by publisher]
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 Jagran Post |
Asthma Symptoms Could Increase With Exposure To Common Toxic Substances
RedOrbit Children who are exposed to polychlorinated biphenyls (PCBs), which were commonly used in a range of industrial products, could be at risk of an increase in asthma symptoms, according to new research. The study will be presented in a poster discussion … PCB toxins raise asthma symptoms Exposure to PCBs worsens asthma symptoms Exposure to common toxic substances could increase asthma symptoms |
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 Eurasia Review |
Exposure to PCBs worsens asthma symptoms
Khaleej Times University of Queensland researchers examined 240 children to assess the impact PCBs are having asthma symptoms. They measured the levels of PCBs found in their blood, along with three pesticides, and also assessed prevalence of wheeze, a common … Exposure To Common Toxic Substances Could Increase Asthma Symptoms PCB Exposure Increases Asthma Risk in Children Exposure to common toxic substances may up kids' asthma symptoms |
View full post on asthma – Google News
Eurasia Review |
Exposure To Common Toxic Substances Could Increase Asthma Symptoms
Eurasia Review Children who are exposed to polychlorinated biphenyls (PCBs), which were commonly used in a range of industrial products, could be at risk of an increase in asthma symptoms, according to new research. The study will be presented in a poster discussion … PCB Exposure Increases Asthma Risk in Children Exposure to common toxic substances may up kids` asthma symptoms |
View full post on asthma – Google News
 Medical Daily |
PCB Exposure Increases Asthma Risk in Children
Medical Daily Our findings suggest that people with high levels of the chemicals in their blood stream are suffering from higher levels of wheeze, a common asthma symptom," said lead author Professor Sly from the University of Queensland in a press release. Other … Exposure to common toxic substances could increase asthma symptoms Exposure to common toxic substances may up kids` asthma symptoms |
View full post on asthma – Google News
 Zee News |
Exposure to common toxic substances could increase asthma symptoms
Medical Xpress September 1, 2012 in Immunology. Vienna, Austria: Children who are exposed to polychlorinated biphenyls (PCBs), which were commonly used in a range of industrial products, could be at risk of an increase in asthma symptoms, according to new research. Exposure to common toxic substances may up kids` asthma symptoms |
View full post on asthma – Google News
Zee News |
Exposure to common toxic substances may up kids` asthma symptoms
Zee News Washington: Children who are exposed to polychlorinated biphenyls (PCBs), which were commonly used in a range of industrial products, could be at risk of an increase in asthma symptoms, a new study has suggested. PCBs were regularly used between … Exposure to common toxic substances could increase asthma symptoms |
View full post on asthma – Google News
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Exposure to common toxic substances could increase asthma symptoms
Science Codex Vienna, Austria: Children who are exposed to polychlorinated biphenyls (PCBs), which were commonly used in a range of industrial products, could be at risk of an increase in asthma symptoms, according to new research. The study will be presented in a … |
View full post on asthma – Google News