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Reality Training: Man is about to die from severe asthma on the roadside
EMS1.com What are signs of a severe asthma attack, meaning it is a life-threatening emergency? As a BLS provider, with a limited scope and few options, what treatment did the police officer provide? What additional interventions are the EMTs and paramedics in … |
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Cold Weather Can Give You Exercise-induced Asthma
Health Hub from Cleveland Clinic Most people with chronic asthma experience asthma symptoms when they exercise. But many people who never experience asthma symptoms also can experience the same chest-tightening and shortness of breath when they work out – especially in cold … |
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Allergy Season Tips from Carolina Asthma and Allergy Center
TWC News CHARLOTTE — Allergy season is upon us, and doctors want those with runny eyes, the sniffles and sore throats to be prepared. Dr. Glen Errington, from the Carolina Asthma and Allergy Center, recommends patients keep windows and doors closed. He also … Safeguarding Yourself this Allergy Season |
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Local middle school student dies Saturday from asthma attack
Estes Park Trail-Gazette Bria Brown, a 14-year-old Estes Park Middle School student died unexpectedly Saturday morning, the victim of an acute asthma attack and respiratory failure, reported the Brown family. Bria was born on Feb. 7, 2001, in Longmont; she and her family moved … |
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From Asthma to Suicidal Thoughts?
Discover Magazine A healthy, stable woman with asthma suddenly finds herself considering suicide despite landing a dream job in a city she loves. What went wrong? By Douglas G. Adler. RELATED TAGS: MENTAL HEALTH. Share on facebookShare on twitterShare on … |
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Teen girls from rural areas have undiagnosed asthma, face higher risk of …
News-Medical.net Teen girls who live in rural areas are more likely than their male counterparts to have undiagnosed asthma, and they often are at a higher risk of depression, according to researchers at the Medical College of Georgia at Georgia Regents University … |
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EurekAlert (press release) |
Teen girls from rural areas more likely to have undiagnosed asthma, be depressed
Medical Xpress Teen girls who live in rural areas are more likely than their male counterparts to have undiagnosed asthma, and they often are at a higher risk of depression, according to researchers at the Medical College of Georgia at Georgia Regents University. Public Release: 24-Feb-2015 Teen girls from rural areas more likely to have … |
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EurekAlert (press release) |
Public Release: 24-Feb-2015 Teen girls from rural areas more likely to have …
EurekAlert (press release) According to data collected during a three-year trial of an asthma program tailored to teens, the prevalence of asthma – both diagnosed and undiagnosed – was about the same in rural areas as it is in urban settings. But more girls had undiagnosed … |
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The Guardian |
Children at risk from cocktail of asthma medications, expert warns
The Guardian Professor Peter van Asperen, a senior respiratory specialist at the Children's hospital at Westmead, said doctors were failing to follow guidelines for asthma management in children, leading to drugs being inappropriately prescribed and lives being put … Popular asthma medication combination could be fatal for children Australian doctors overprescribing combination of asthma medications, putting … Asthma combo therapy putting kids at risk |
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| Related Articles |
Undifferentiated Bronchial Fibroblasts Derived from Asthmatic Patients Display Higher Elastic Modulus than Their Non-Asthmatic Counterparts.
PLoS One. 2015;10(2):e0116840
Authors: Sarna M, Wojcik KA, Hermanowicz P, Wnuk D, Burda K, Sanak M, Czy? J, Michalik M
Abstract
During asthma development, differentiation of epithelial cells and fibroblasts towards the contractile phenotype is associated with bronchial wall remodeling and airway constriction. Pathological fibroblast-to-myofibroblast transition (FMT) can be triggered by local inflammation of bronchial walls. Recently, we have demonstrated that human bronchial fibroblasts (HBFs) derived from asthmatic patients display some inherent features which facilitate their FMT in vitro. In spite of intensive research efforts, these properties remain unknown. Importantly, the role of undifferentiated HBFs in the asthmatic process was systematically omitted. Specifically, biomechanical properties of undifferentiated HBFs have not been considered in either FMT or airway remodeling in vivo. Here, we combine atomic force spectroscopy with fluorescence microscopy to compare mechanical properties and actin cytoskeleton architecture of HBFs derived from asthmatic patients and non-asthmatic donors. Our results demonstrate that asthmatic HBFs form thick and aligned ‘ventral’ stress fibers accompanied by enlarged focal adhesions. The differences in cytoskeleton architecture between asthmatic and non-asthmatic cells correlate with higher elastic modulus of asthmatic HBFs and their increased predilection to TGF-?-induced FMT. Due to the obvious links between cytoskeleton architecture and mechanical equilibrium, our observations indicate that HBFs derived from asthmatic bronchi can develop considerably higher static tension than non-asthmatic HBFs. This previously unexplored property of asthmatic HBFs may be potentially important for their myofibroblastic differentiation and bronchial wall remodeling during asthma development.
PMID: 25679502 [PubMed – as supplied by publisher]
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