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8% children suffering from bronchial asthma in Punjab: Health authorities reveal
Times of India CHANDIGARH: It is not just an increase in the number of asthma cases coming to hospitals and dispensaries across Punjab, but the high incidence of children suffering from respiratory disorders that has become a matter of concern for the health authorities. |
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 eMaxHealth |
Red meat allergy linked to antibodies from tick bite
eMaxHealth According to results of an investigation presented at the Annual Scientific Meeting of the American College of Allergy, Asthma and Immunology (ACAAI), symptoms of sneezing, headache, wheezing and more can occur hours after eating meat in areas of the … Most Children Allergic to Egg Can Tolerate Baked Hen's Egg Wildfire smoke impacts allergy and asthma sufferers Lone star tick may turn South vegetarian |
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Asthma Researcher Makes Rare Leap from Graduate School to UCSF Principal …
UCSF Today Most young scientists fresh out of graduate school are content to begin a post-doctoral fellowship, working for an established faculty member. But for Christopher Allen, PhD, award-winning research in asthma meant the fast-track onto UCSF's faculty. |
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Asthmatic children may suffer more from dirty hands – chicagotribune.com
Chicago Tribune NEW YORK (Reuters Health) – An arsenal of hand sanitizers, hygiene education and good old-fashioned soap failed to prevent asthma attacks among school children in one Alabama county. For children with asthma, the common cold is the top trigger of … |
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 Proactive Investors USA & Canada |
Merck 3Q profit up 2 pct despite sales dip from generic competition to asthma …
Washington Post Drugmaker Merck & Co. said Friday that third-quarter profit rose 2 percent as reduced spending on overhead offset lower sales due to new generic competition for its top-selling drug, Singulair. The maker of diabetes pill Januvia beat Wall Street's … Merck tops view, newer drugs cushion asthma drug blow Merck Q3 earnings edge up despite decline in sales Merck's Profit Rises 2.2% |
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 Globe and Mail |
Merck 3Q profit up 2 pct despite sales dip from generic competition to asthma …
Newser The maker of diabetes pill Januvia beat Wall Street's profit expectations. The company also narrowed its 2012 profit forecast, to a range of $2.08 to $2.24 per share, from its July forecast of $2.04 to $2.30. Merck, based in Whitehouse Station, N.J … Merck tops view, newer drugs cushion asthma drug blow Merck posts mixed results for third quarter MERCK & CO., INC. : Merck 3rd-Quarter Profit Up 2.2%; Narrows Year View |
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Keeping sick buildings from making children sick
Cincinnati.com “We were shocked when we saw the same management,” said Andrew Beck, a Children's pediatrician specializing in asthma analysis and treatment. He is the lead author of an article on the project that will be published in the November issue of Pediatrics. |
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Do Hay Fever, Asthma, Lower Death Risk From Colorectal Cancer?
EndoNurse ANAHEIM, Calif.—People with both hay fever and asthma—but not people with only one of these two conditions—experienced an approximately 17 percent lower risk for dying from colorectal cancer, according to data presented at the 11th Annual AACR … |
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Hay Fever, Asthma Combination Linked to Lower Risk for Death From Colorectal …
Bioscience Technology ANAHEIM, Calif. — People with both hay fever and asthma — but not people with only one of these two conditions — experienced an approximately 17 percent lower risk for dying from colorectal cancer, according to data presented at the 11th Annual AACR … |
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CD44 variant isoforms are specifically expressed on peripheral blood lymphocytes from asthmatic patients.
Exp Ther Med. 2012 Jul;4(1):79-83
Authors: Yang C, Liang H, Zhao H, Jiang X
Abstract
Asthma is a disease characterized by chronic airway inflammation, and Th2 cells play a critical role in initiating and sustaining asthmatic inflammation. It has been shown that CD44 expressed on CD4(+) T cells plays a critical role in the accumulation of antigen-specific Th2 cells in the development of airway hyperresponsiveness induced by antigen challenge in the airways. The aim of this study was to determine whether there are specific CD44 variant isoforms (CD44v) expressed on lymphocytes from asthmatic patients. We collected whole blood samples from 103 normal subjects, 165 subjects with asthma and 104 with pneumonia. Peripheral blood lymphocyte isolation was performed, and total RNA was extracted from the isolated lymphocytes, using nested PCR for specific CD44v amplification on lymphocytes. Demographic variables were analyzed using linear regression in order to determine whether the expression of CD44v was correlated with these demographic features. The nested PCR results revealed that CD44v5 was expressed by 55.2% of asthma patients, which was significantly higher than levels of expression in the other groups. Lower percentages of individuals in the normal subject group exhibited expression of CD44v5 and CD44v6. The data demonstrated that the percentage of individuals in the pneumonia group expressing CD44v5 was 29.0%, but a higher percentage of these patients expressed CD44v6. CD44v5 expression was positively correlated with IgE levels (p=0.032) in the asthmatic patient group, and CD44v6 was significantly positively correlated with the neutrophil count (p<0.05). CD44v5 was expressed by a higher proportion of asthmatic patients than other subjects and thus may play an important role in the pathogenesis of asthma. These findings may offer a new target for the diagnosis and treatment of asthma and may also provide insights into the mechanisms of asthma development.
PMID: 23060926 [PubMed – as supplied by publisher]
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