[Unmet need in asthma management and future treatment options].

Related Articles

[Unmet need in asthma management and future treatment options].

Pneumologie. 2015 Jan;69(1):36-47

Authors: Gillissen A

Abstract
Despite health initiatives and extensive guideline efforts for advancing the management of asthma, evidence from epidemiologic studies suggests, that many asthma patients still have uncontrolled disease. The percentage of the uncontrolled disease stage is highly prevalent and eventually succeeds the 50?% range depending on the disease severity. There is urgent need for improved care particularly in moderate as well as in severe asthma. Implementation of treatment plans, the focus on symptom control, better patient-caretaker communication and most importantly improvement of specific treatment options are the cornerstones for success. Tiotropium, the first long-term antimuscarinic compound, was approved for asthma treatment in 2014, new developed inhaled corticosteroids as well as ?2-mimetics and inhaler types will enhance the physician’s armamentarium to treat this disease better. Agents aimed at inhibiting cytokines, such as mepoluzimab, daclizumab, reslizumab and others hold to various degree promise in the treatment of asthma. Other agents under investigation include phosphodiesterase type 4 inhibitors and oligonucleotides. In summary, there is future promise for substantial therapeutic advances in moderate and severe persistent asthma.

PMID: 25599141 [PubMed – in process]

View full post on pubmed: asthma

Future asthma treatment may target trigger allergens – Gizmag


Gizmag

Future asthma treatment may target trigger allergens
Gizmag
Asthma attacks are terrifying. They feel almost like the world is closing in around you as you wheeze and cough and gasp for breath. And they often strike suddenly, without warning, when an innocuous event stirs up dust or pollen around you. That
Neutralising allergen can treat asthma betterZee News

all 4 news articles »

View full post on asthma – Google News

A Statistical Modeling Framework for Projecting Future Ambient Ozone and its Health Impact due to Climate Change.

Related Articles

A Statistical Modeling Framework for Projecting Future Ambient Ozone and its Health Impact due to Climate Change.

Atmos Environ (1994). 2014 Jun 1;89:290-297

Authors: Chang HH, Hao H, Sarnat SE

Abstract
The adverse health effects of ambient ozone are well established. Given the high sensitivity of ambient ozone concentrations to meteorological conditions, the impacts of future climate change on ozone concentrations and its associated health effects are of concern. We describe a statistical modeling framework for projecting future ozone levels and its health impacts under a changing climate. This is motivated by the continual effort to evaluate projection uncertainties to inform public health risk assessment. The proposed approach was applied to the 20-county Atlanta metropolitan area using regional climate model (RCM) simulations from the North American Regional Climate Change Assessment Program. Future ozone levels and ozone-related excesses in asthma emergency department (ED) visits were examined for the period 2041-2070. The computationally efficient approach allowed us to consider 8 sets of climate model outputs based on different combinations of 4 RCMs and 4 general circulation models. Compared to the historical period of 1999-2004, we found consistent projections across climate models of an average 11.5% higher ozone levels (range: 4.8%, 16.2%), and an average 8.3% (range: -7% to 24%) higher number of ozone exceedance days. Assuming no change in the at-risk population, this corresponds to excess ozone-related ED visits ranging from 267 to 466 visits per year. Health impact projection uncertainty was driven predominantly by uncertainty in the health effect association and climate model variability. Calibrating climate simulations with historical observations reduced differences in projections across climate models.

PMID: 24764746 [PubMed – as supplied by publisher]

View full post on pubmed: asthma

Transmitting future asthma by smoking today – Science Daily (press release)

Transmitting future asthma by smoking today
Science Daily (press release)
Sep. 20, 2013 — Asthma is a serious public health problem. An estimated 300 million people worldwide suffer from this sometimes deadly lung disease, a number expected to increase to 400 million by 2025. One well-established risk factor for asthma is 
Study Reports Pregnant Women who Smoke Increase Asthma Risk in Great Counsel & Heal

all 2 news articles »

View full post on asthma – Google News

Nanoparticles Stop Multiple Sclerosis In Mice and could treat food allergies … – Next Big Future

Nanoparticles Stop Multiple Sclerosis In Mice and could treat food allergies
Next Big Future
Nanoparticles Stop Multiple Sclerosis In Mice and could treat food allergies, asthma and other autoimmune diseases · Email ThisBlogThis!Share to TwitterShare to Facebook · Tweet · NBC News – Researchers trying to find a way to treat multiple sclerosis

and more »

View full post on asthma – Google News