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LINX®, a Novel Treatment for Patients With Refractory Asthma Complicated by Gastroesophageal Reflux Disease
Medscape Background: Gastroesophageal reflux disease is one of the most common comorbidities in patients with asthma. Gastroesophageal reflux disease can be linked to difficult-to-control asthma. Current management includes gastric acid suppression therapy and … |
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Nocturnal gastroesophageal reflux, asthma and symptoms of obstructive sleep apnoea: a longitudinal, general population study.
Eur Respir J. 2012 Sep 27;
Authors: Emilsson OI, Bengtsson A, Franklin KA, Torén K, Benediktsdóttir B, Farkhooy A, Weyler J, Dom S, Backer WD, Gislason T, Janson C
Abstract
Nocturnal gastroesophageal reflux (nGER) is associated with asthma and obstructive sleep apnoea (OSA). Our aim was to investigate whether nGER is a risk factor for onset of asthma and onset of respiratory and OSA symptoms in a prospective population based study.We invited 2640 subjects from Iceland, Sweden and Belgium for two evaluations over a nine years interval. They participated in structured interviews, answered questionnaires, underwent spirometries and methacholine challenge testing. nGER was defined by reported symptoms.Subjects with persistent nGER (n=123) had an independent increased risk of new asthma at follow-up [OR (95% CI): 2.3 (1.1-4.9)]. Persistent nGER was independently related to onset of respiratory symptoms [OR (95% CI): 3.0 (1.6-5.6)]. The risk of developing symptoms of OSA was increased in subjects with new and persistent nGER [OR (95% CI): 2.2 (1.3-1.6) and 2.0 (1.0-3.7), respectively]. No significant association was found between nGER and lung function or bronchial responsiveness.Persistent symptoms of nocturnal gastroesophageal reflux contributes to the development of asthma and respiratory symptoms. New onset of OSA symptoms is higher among subjects with symptoms of nGER. These findings support that nGER may play a role in the genesis of respiratory symptoms and diseases.
PMID: 23018910 [PubMed – as supplied by publisher]
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Gastroesophageal Reflux Symptoms and Comorbid Asthma and Posttraumatic Stress Disorder Following the 9/11 Terrorist Attacks on World Trade Center in New York City.
Am J Gastroenterol. 2011 Sep 6;
Authors: Li J, Brackbill RM, Stellman SD, Farfel MR, Miller-Archie SA, Friedman S, Walker DJ, Thorpe LE, Cone J
Abstract
OBJECTIVES:Excess gastroesophageal reflux disease (GERD) was reported in several populations exposed to the September 11 2001 (9/11) terrorist attacks on the World Trade Center (WTC). We examined new onset gastroesophageal reflux symptoms (GERS) since 9/11 and persisting up to 5-6 years in relation to 9/11-related exposures among the WTC Health Registry enrollees, and potential associations with comorbid asthma and posttraumatic stress disorder (PTSD).METHODS:This is a retrospective analysis of 37,118 adult enrollees (i.e., rescue/recovery workers, local residents, area workers, and passersby in lower Manhattan on 9/11) who reported no pre-9/11 GERS and who participated in two Registry surveys 2-3 and 5-6 years after 9/11. Post-9/11 GERS (new onset since 9/11) reported at first survey, and persistent GERS (post-9/11 GERS reported at both surveys) were analyzed using log-binomial regression.RESULTS:Cumulative incidence was 20% for post-9/11 GERS and 13% for persistent GERS. Persistent GERS occurred more often among those with comorbid PTSD (24%), asthma (13%), or both (36%) compared with neither of the comorbid conditions (8%). Among enrollees with neither asthma nor PTSD, the adjusted risk ratio (aRR) for persistent GERS was elevated among: workers arriving at the WTC pile on 9/11 (aRR=1.6; 95% confidence interval (CI) 1.3-2.1) or working at the WTC site > 90 days (aRR=1.6; 1.4-2.0); residents exposed to the intense dust cloud on 9/11 (aRR=1.5; 1.0-2.3), or who did not evacuate their homes (aRR=1.7; 1.2-2.3); and area workers exposed to the intense dust cloud (aRR=1.5; 1.2-1.8).CONCLUSIONS:Disaster-related environmental exposures may contribute to the development of GERS. GERS may be accentuated in the presence of asthma or PTSD.Am J Gastroenterol advance online publication, 6 September 2011; doi:10.1038/ajg.2011.300.
PMID: 21894225 [PubMed – as supplied by publisher]
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