VNN1 Gene Could Serve As a Biomarker for Response to Corticosteroids in … – Lung Disease News


Lung Disease News

VNN1 Gene Could Serve As a Biomarker for Response to Corticosteroids in
Lung Disease News
According to study investigator Gurjit Khurana Hershey, MD, PhD, director of Asthma Research at Cincinnati Children's Hospital Medical Center, “Genome-wide analysis allowed us to identify a gene, whose expression discriminated between good and poor …

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Gene may play part in how kids respond to asthma meds – WSFA


WSFA

Gene may play part in how kids respond to asthma meds
WSFA
{HealthDay News) — Researchers say they've identified a gene that affects whether children with asthma respond to corticosteroids. Corticosteroids are the most effective treatment for chronic asthma and acute asthma attacks, but some children don't
Association Between Adverse Childhood Experiences and Pediatric Asthma Lung Disease News
Children exposed to adverse childhood experience more likely to develop asthmaNews-Medical.net

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Gene May Play Part in How Kids Respond to Asthma Meds: Study – U.S. News & World Report


Fox News

Gene May Play Part in How Kids Respond to Asthma Meds: Study
U.S. News & World Report
WEDNESDAY, April 22, 2015 (HealthDay News) — Researchers say they've identified a gene that affects whether children with asthma respond to corticosteroids. Corticosteroids are the most effective treatment for chronic asthma and acute asthma attacks, …
Scientists find potential new therapy for hard-to-treat pediatric asthma patientsFox News
Genetic variance explains poor response to common asthma medicationsMedical Xpress
Genetic Variance Explains Poor Response to Asthma MedicationsDrug Discovery & Development
GenomeWeb –Monthly Prescribing Reference
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Transcriptome analysis of controlled and therapy-resistant childhood asthma reveals distinct gene expression profiles.

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Transcriptome analysis of controlled and therapy-resistant childhood asthma reveals distinct gene expression profiles.

J Allergy Clin Immunol. 2015 Apr 9;

Authors: Persson H, Kwon AT, Ramilowski JA, Silberberg G, Söderhäll C, Orsmark-Pietras C, Nordlund B, Konradsen JR, de Hoon MJ, Melén E, Hayashizaki Y, Hedlin G, Kere J, Daub CO

Abstract
BACKGROUND: Children with problematic severe asthma have poor disease control despite high doses of inhaled corticosteroids and additional therapy, leading to personal suffering, early deterioration of lung function, and significant consumption of health care resources. If no exacerbating factors, such as smoking or allergies, are found after extensive investigation, these children are given a diagnosis of therapy-resistant (or therapy-refractory) asthma (SA).
OBJECTIVE: We sought to deepen our understanding of childhood SA by analyzing gene expression and modeling the underlying regulatory transcription factor networks in peripheral blood leukocytes.
METHODS: Gene expression was analyzed by using Cap Analysis of Gene Expression in children with SA (n = 13), children with controlled persistent asthma (n = 15), and age-matched healthy control subjects (n = 9). Cap Analysis of Gene Expression sequencing detects the transcription start sites of known and novel mRNAs and noncoding RNAs.
RESULTS: Sample groups could be separated by hierarchical clustering on 1305 differentially expressed transcription start sites, including 816 known genes and several novel transcripts. Ten of 13 tested novel transcripts were validated by means of RT-PCR and Sanger sequencing. Expression of RAR-related orphan receptor A (RORA), which has been linked to asthma in genome-wide association studies, was significantly upregulated in patients with SA. Gene network modeling revealed decreased glucocorticoid receptor signaling and increased activity of the mitogen-activated protein kinase and Jun kinase cascades in patients with SA.
CONCLUSION: Circulating leukocytes from children with controlled asthma and those with SA have distinct gene expression profiles, demonstrating the possible development of specific molecular biomarkers and supporting the need for novel therapeutic approaches.

PMID: 25863981 [PubMed – as supplied by publisher]

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Investigating mutations of a crucial gene might assist treatment and … – Medical Xpress


Medical Xpress

Investigating mutations of a crucial gene might assist treatment and
Medical Xpress
Allergic asthma affects the lives of millions but new research may help to prevent or suppress an allergic response. Credit: Giorez/iStock/Thinkstock. Mutations in a specific gene are linked with human susceptibility to allergic asthma according to new

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Gene discovery could improve asthma therapy – Futurity: Research News


Times of Malta

Gene discovery could improve asthma therapy
Futurity: Research News
Scientists have discovered more than 30 genes that strongly affect an antibody involved in allergies and asthma. Some of the genes could provide targets for drugs to treat those conditions, according to the new study. Allergies affect as much as 30
Genes involved in Allergies, Asthma identifiedBusiness Standard
Genes' 'key role' in asthmaTimes of Malta
Genes involved in allergies, asthma discovered: ScientistsNews Nation

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Study to Examine the Cytokine Levels, Gene Expression and Safety of a Single Nasal Dose of JNJ-43260295, in Healthy Participants, and Atopic Participants With Mild to Mild-Persistent Asthma

Conditions:   Healthy;   Asthma
Interventions:   Drug: JNJ-43260295;   Drug: Placebo;   Other: Nasal Allergen Challenge
Sponsor:   Janssen Research & Development, LLC
Not yet recruiting – verified September 2014

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Asthmatic Kids With Gene Variant May Not Benefit From Inhaler Drugs; British … – Medical Daily


Medical Daily

Asthmatic Kids With Gene Variant May Not Benefit From Inhaler Drugs; British
Medical Daily
Such controller and emergency inhalers are often the primary treatment for asthma in children and adults around the world, with 9.3 percent of American children suffering the respiratory disease, according to the Centers for Disease Control and Prevention.

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