Gene Test Gives Clues to Asthma Persistence – MedPage Today


Counsel & Heal

Gene Test Gives Clues to Asthma Persistence
MedPage Today
Analysis of data from a four-decade longitudinal study involving almost 1,000 people revealed that those with higher genetic risk scores were more than a third more likely to continue to suffer from asthma as adults than were those with lower scores
Test if child will grow out of asthma: Kiwi firstNew Zealand Herald
Genetic Tests May Predict Who Will Grow Out of AsthmaCounsel & Heal
Genetic tests can show if children are likely to grow out of asthma according Daily Mail

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Yourwellness Magazine Investigates How Gene Markers Affect Asthma Treatment – PR Web (press release)


PR Web (press release)

Yourwellness Magazine Investigates How Gene Markers Affect Asthma Treatment
PR Web (press release)
With this in mind, Yourwellness Magazine reported on how asthma patients' DNA impacts the effectiveness of their treatment. According to Yourwellness Magazine, “What's recently become apparent is that, due to a genetic abnormality in certain peoples

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Exposure to violence, gene changes linked to asthma in Puerto Rican children – Medical Xpress

Exposure to violence, gene changes linked to asthma in Puerto Rican children
Medical Xpress
Puerto Rican children who have asthma are more likely to be exposed to violence and to have changes in a gene that is associated with stress, according to a new study led by researchers at Children's Hospital of Pittsburgh of UPMC and the University of

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Air Pollutants Associated With Asthma-Related Gene Changes – Medscape

Air Pollutants Associated With Asthma-Related Gene Changes
Medscape
"We've shown that the gene being changed is directly associated with asthma and severity of the asthma," Kari Nadeau, MD, told Medscape Medical News, adding that it was "also associated with a higher likelihood of elevated immunoglobulin, which is also
Air pollution chemicals linked to asthmaUPI.com

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RGS5 gene and therapeutic response to short acting bronchodilators in paediatric asthma patients.

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RGS5 gene and therapeutic response to short acting bronchodilators in paediatric asthma patients.

Pediatr Pulmonol. 2012 Nov 28;

Authors: Labuda M, Laberge S, Brière J, Bérubé D, Krajinovic M

Abstract
Short-acting ?2-adrenergic receptor agonists are commonly used bronchodilators for symptom relief in asthmatics. Recent evidence demonstrated that prolonged exposure of cultured airway smooth muscle cells to ?2 agonists directly augments procontractile signaling pathways with the change in expression of regulator of G protein signaling 5 (RGS5). The aim of this study was to test whether genetic variants in RGS5 gene affect the response to short acting ?2-agonists. Bronchodilator responsiveness was assessed in 137 asthmatic children by % change in baseline forced expiratory volume in 1?sec (FEV(1) ) after administration of albuterol. The analyses were performed in patients with FEV(1) /FVC ratio below 0.9 (FVC-forced vital capacity, n?=?99). FEV(1) % change adjusted for baseline FEV(1) values was significantly different between genotypes of rs10917696 C/T polymorphism (P?=?0.008). The association remained significant with inclusion of age, sex, atopy, parental smoking, and controller medications into multivariate model (P?=?0.005). We also identified additive effect on the treatment outcome with previously published genetic variant G/A rs1544791 in phosphodiesterase 4 (PDE4D) gene. Carriers of two risk alleles (C and G) had adjusted mean % FEV(1) change value 4.6?±?1.3, while carriers of one and none of the risk alleles had 8.1?±?0.7% and 13.5?±?2.4%, respectively, P?=?0.001. Our work identifies a new genetic variant in RGS5 demonstrating additive effect with PDE4D, both implicated in modulation of asthma treatment. Pediatr Pulmonol. © 2012 Wiley Periodicals, Inc.

PMID: 23193110 [PubMed – as supplied by publisher]

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Master regulator gene discovered in virus-induced asthma – Science Network Western Australia

Master regulator gene discovered in virus-induced asthma
Science Network Western Australia
The discovery of interferon regulatory factor 7 (IRF7) as the hub of the molecular web underlying an asthma attack opens up opportunities for the development of new treatments for virus-induced asthma exacerbations.A SIMPLE question regarding what

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