Scientists Seek Genetic Clues To Asthma’s Toll On Black Children – NPR


NPR

Scientists Seek Genetic Clues To Asthma's Toll On Black Children
NPR
Zunika Crenshaw cringes as a tire swing whips her children around in circles just a little too fast. It's a sunny afternoon in the park, in Pleasanton, Calif. As her children play, she keeps a close watch on their breathing. She says asthma is in her
Scientists Seek Genetic Clues To Asthma's Toll In Black ChildrenNorth Country Public Radio
Scientsts Seek Genetic Clues To Why Asthma Is Deadlier In BlacksKABC

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Scientsts Seek Genetic Clues To Why Asthma Is Deadlier In Blacks – Boise State Public Radio


Boise State Public Radio

Scientsts Seek Genetic Clues To Why Asthma Is Deadlier In Blacks
Boise State Public Radio
"The majority of genetic studies, not just in asthma but in most diseases, are done in Caucasian- or European-descent populations," White explains. "The longest studies do not really include very many minority populations, which means that most

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Novel genetic method could lead to vaccine for cancer, asthma – Times of India


The Siasat Daily

Novel genetic method could lead to vaccine for cancer, asthma
Times of India
Danish researchers have developed a novel genetic method that could lead to the development of safe and effective vaccines for controlling diseases such as cancer, asthma, and allergies. "The major research breakthrough is that we have created a
Novel technique to develop vaccines for cancer, asthma: studyThe Siasat Daily

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Common genetic variation safeguards children from asthma – ScienceBlog.com (blog)


ScienceBlog.com (blog)

Common genetic variation safeguards children from asthma
ScienceBlog.com (blog)
Exhaled nitric oxide is a biomarker of airway inflammation; higher levels of it increase a child's risk of developing asthma. Children with a common variation of “NOS2,” the primary gene that produces nitric oxide in airways, tend to have lungs that

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Genetic polymorphisms of the TNF-?-308G/A are associated with metabolic syndrome in asthmatic patients from Hebei province, China.

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Genetic polymorphisms of the TNF-?-308G/A are associated with metabolic syndrome in asthmatic patients from Hebei province, China.

Int J Clin Exp Pathol. 2015;8(10):13739-46

Authors: Yang YH, Liu YQ, Zhang L, Li H, Li XB, Ouyang Q, Zhu GY

Abstract
Asthma is a complex inflammatory disease involving the critical actions of several important cytokines. Epidemiological data show that obesity could increase the risk of asthma, and insulin resistance, or metabolic syndrome are an important risk factor for obesity asthma. Some studies identified that upstream of the transcription start site within the TNF-? gene promoter region-308 polymorphism was associated insulin resistance or metabolic disorders, while this site was closely related to asthma. But no research was performed to evaluate the influence of TNF-?-308G/A polymorphism on metabolic syndrome in asthmatic patients. Here, we recruited 248 asthmatic patients, who were separated into asthma with Mets/asthma without Mets groups and 226 matched healthy controls from Hebei Province to evaluate the influence of TNF-?-308G/A polymorphism on metabolic syndrome in asthmatic patients. Single nucleotide polymorphism of TNF-?-308 locus was genotyped using PCR-RFLP. Some biochemical variables were also determined. Our result showed that the genotypic and allelic frequency of rs1800629 did not show significant difference between asthmatic patients and normal controls. However, the frequency of A allele was signi?cantly higher in asthma group with Mets (22.36%) than in controls (15.71%) (P = 0.02; OR = 0.647; 95% CI = 0.447-0.936). After analyzing the relationship between biochemical features of patients and genotype of TNF-?-308G/A, we found levels of LDL cholesterol, TNF-? and insulin, and HOMA-IR were significantly higher in the asthmatic patients carrying the GA and AA genotypes than in the carriers of GG genotype of rs1800629 (P = 0.029, P = 0.022, P = 0.043, respectively). Thus, our data suggested that TNF-?-308G/A variation was related to metabolic phenotype in asthma patients. Furthermore, we first identified TNF-?-308 A allele was the risk factor for asthmatic patients with Mets in Hebei population, China.

PMID: 26722602 [PubMed – in process]

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