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Genetic evidence that body mass increases the risk of asthma in mid-childhood
Medical Xpress Some of the increase in asthma risk toward the end of the 20th century could be attributed to the increase in body mass index (BMI) in mid-childhood, according to new research published in this week's PLOS Medicine. The study, led by Raquel Granell … |
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AstraZeneca Buys Rights to Synairgen Asthma Compound
Genetic Engineering News SNG001 is an inhaled interferon beta (IFN-beta) for respiratory tract viral infections in patients with severe asthma. AstraZeneca said it plans early next years to launch a Phase IIa study of SNG001 in patients with severe asthma—a trial it said … |
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Novel Antibody Demonstrates Promise against Asthma
Genetic Engineering News Scientists at St. Joseph's Healthcare Hamilton and McMaster University report that they successfully tested an antibody (AMG 157) that can improve the quality of life for individuals with asthma by relieving inflammation in the lungs. The study … Amgen drug for allergy asthma shows promise in early tests Novel Biologic Promising for Allergic Asthma New antibody can improve quality of life for individuals with asthma |
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Times of India |
Genetic variants may explain link between infant antibiotic use and asthma
Medical News Today But this latest study, conducted by researchers from the University of Manchester in the UK, is believed to be the first to show that it is not the antibiotics themselves that increase asthma risk for children, but impaired viral immunity and certain … Antibiotics might not be behind your kid's asthma Babies given antibiotics have higher asthma risk Early antibiotic use may cause asthma in children |
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Novel Molecular Target for Asthma and Cancer Identified
Genetic Engineering News Researchers at the Johns Hopkins Kimmel Cancer Center described an enzyme involved in T-cell regulation that could be a useful target in treating asthma and boosting the effects of certain cancer therapies. In a study (“The AGC kinase SGK1 regulates … |
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RedOrbit |
23andMe Helps Find New Genetic Associations For Asthma-With-Hay Fever
RedOrbit 23andMe, the leading personal genetics company, has participated in the first ever genome-wide association study of the combined asthma-with-hay fever phenotype. Led by researchers at the QIMR Berghofer Medical Research Institute, the study identified … |
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23andMe helps identify 11 new genetic associations for asthma-with-hay fever
Science Codex Mountain View, Calif. –January 28, 2014 23andMe, the leading personal genetics company, has participated in the first ever genome-wide association study of the combined asthma-with-hay fever phenotype. Led by researchers at the QIMR Berghofer … |
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11 new genetic associations for asthma-with-hay fever
Medical Xpress 23andMe has participated in the first ever genome-wide association study of the combined asthma-with-hay fever phenotype. Led by researchers at the QIMR Berghofer Medical Research Institute, the study identified 11 independent genetic markers … |
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Laboratory Equipment |
Salmonella Infections Reduce Asthma Attacks
Genetic Engineering News Scientists in Germany say they have pinpointed the mechanism by which Salmonella infections can reduce the incidence of asthma in mice. They point out that their research (“Salmonella Typhimurium Infection Induced CD11b+Gr1+ Cells Ameliorate Allergic … Salmonella Infection Mitigates Asthma |
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| Related Articles |
Influence of the Adjuvants and Genetic Background on the Asthma Model Using Recombinant Der f 2 in Mice.
Immune Netw. 2013 Dec;13(6):295-300
Authors: Chang YS, Kim YK, Jeon SG, Kim SH, Kim SS, Park HW, Min KU, Kim YY, Cho SH
Abstract
Der f 2 is the group 2 major allergen of a house dust mite (Dermatophagoides farinae) and its function has been recently suggested. To determine the optimal condition of sensitization to recombinant Der f 2 (rDer f 2) in murine model of asthma, we compared the effectiveness with different adjuvants in BALB/c and C57BL/6 mice. Mice from both strains sensitized with rDer f 2 by intraperitoneal injection or subcutaneous injection on days 1 and 14. The dosage was 20 µg. Freund’s adjuvants with pertussis toxin (FP) or alum alone were used as adjuvants. On days 28, 29, and 30, mice were challenged intranasally with 0.1% rDer f 2. We evaluated airway hyperresponsivenss, eosinophil proportion in lung lavage, airway inflammation, and serum allergen specific antibody responses. Naive mice were used as controls. Airway hyperresponsiveness was increased in C57BL/6 with FP, and BALB/c with alum (PC200: 13.5±6.3, 13.2±6.7 vs. >50 mg/ml, p<0.05). The eosinophil proportion was increased in all groups; C57BL/6 with FP, BALB/c with FP, C57BL/6 with alum, BALB/c with alum (24.8±3.6, 20.3±10.3, 11.0±6.9, 5.7±2.8, vs. 0.0±0.0%, p<0.05). The serum allergen specific IgE levels were increased in C57BL/6 with FP or alum (OD: 0.8±1.4, 1.1±0.8, vs. 0.0±0.0). C57BL/6 mice were better responders to rDer f 2 and as for adjuvants, Freund’s adjuvant with pertussis toxin was better.
PMID: 24385949 [PubMed]
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