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Genetics of Asthma in African Americans
GenomeWeb Asthma affects some populations in the US more than others, NPR reports. African-American children, it adds, are twice as likely as white children to have asthma and are 10 times as likely to die of asthma-related complications. And genetics appear to … |
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Related Articles |
Genetics of allergy and allergic sensitization: common variants, rare mutations.
Curr Opin Immunol. 2015 Sep 16;36:115-126
Authors: Bønnelykke K, Sparks R, Waage J, Milner JD
Abstract
Our understanding of the specific genetic lesions in allergy has improved in recent years due to identification of common risk variants from genome-wide association studies (GWAS) and studies of rare, monogenic diseases. Large-scale GWAS have identified novel susceptibility loci and provided information about shared genetics between allergy, related phenotypes and autoimmunity. Studies of monogenic diseases have elucidated critical cellular pathways and protein functions responsible for allergy. These complementary approaches imply genetic mechanisms involved in Th2 immunity, T-cell differentiation, TGF? signaling, regulatory T-cell function and skin/mucosal function as well as yet unknown mechanisms associated with newly identified genes. Future studies, in combination with data on gene expression and epigenetics, are expected to increase our understanding of the pathogenesis of allergy.
PMID: 26386198 [PubMed – as supplied by publisher]
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Air quality, genetics 'influence asthma'
Ninemsn Air quality, genetics 'influence asthma'. 11:42am March 15, 2013. Sydney's air pollution could boost the chances of developing childhood asthma, especially if children are already genetically predisposed to it, a study has found. Animals that choose … |
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Asthma linked to Genetics
Ivanhoe (Ivanhoe Newswire) – More than 25 million Americans have asthma, according to the Asthma and Allergy Foundation of America, and African American males are among those at greatest risk for severe attacks. A new study shows that genetics may be … |
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Respiratory genetics: joined-up thinking
Medical Xpress Anjana Ahuja went to meet them at the National Heart and Lung Institute in west London to talk asthma, genetics and the secrets of a successful working relationship. William Cookson smiles ruefully as he recalls the beginning of his research career, … |
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 Wellcome Trust |
Feature: Respiratory genetics – joined-up thinking
Wellcome Trust Anjana Ahuja went to meet them at the National Heart and Lung Institute in west London to talk asthma, genetics and the secrets of a successful working relationship. William Cookson smiles ruefully as he recalls the beginning of his research career, … |
View full post on asthma – Google News
 Baltimore Sun |
Hopkins to study genetics of asthma in African Americans
Baltimore Sun By Andrea K. Walker, The Baltimore Sun Johns Hopkins researchers, in the largest study to date, will map the genetic code for asthma in people of African descent in hopes of better understanding why the disease and other allergy-related ailments … $9.5 Million Federal Grant to Support "Asthma Genome" Project with African … Johns Hopkins wins $8.5M to study asthma among blacks |
View full post on asthma – Google News
Baltimore Sun |
Hopkins to study genetics of asthma in African Americans
Baltimore Sun By Andrea K. Walker, The Baltimore Sun Johns Hopkins researchers, in the largest study to date, will map the genetic code for asthma in people of African descent in hopes of better understanding why the disease and other allergy-related ailments … $9.5 Million Federal Grant to Support "Asthma Genome" Project with African … Johns Hopkins wins $8.5M to study asthma among blacks |
View full post on asthma – Google News
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Researchers look to genetics to understand African American-asthma link
Baltimore Sun (blog) By Meredith Cohn Researchers working to discover why African Americans disproportionately suffer from asthma are planning to map the genetic code of 1000 people of African descent in four years. The Johns Hopkins-led team of experts in genetics, … $9.5 Million Federal Grant to Support "Asthma Genome" Project with African … |
View full post on asthma – Google News
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Researcher look to genetics to understand African American-asthma link
Baltimore Sun (blog) By Meredith Cohn Researchers working to discover why African Americans disproportionately suffer from asthma are planning to map the genetic code of 1000 people of African descent in four years. The Johns Hopkins-led team of experts in genetics, … $9.5 Million Federal Grant to Support "Asthma Genome" Project with African … |
View full post on asthma – Google News