Cytokine profile of bronchoalveolar lavage fluid from a mouse model of bronchial asthma during seasonal H1N1 infection.

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Cytokine profile of bronchoalveolar lavage fluid from a mouse model of bronchial asthma during seasonal H1N1 infection.

Cytokine. 2014 Jul 3;69(2):206-210

Authors: Hasegawa S, Wakiguchi H, Okada S, Gui Kang Y, Fujii N, Hasegawa M, Hasegawa H, Ainai A, Atsuta R, Shirabe K, Toda S, Wakabayashi-Takahara M, Morishima T, Ichiyama T

Abstract
BACKGROUND: Several studies support the role of viral infections in the pathogenesis of asthma exacerbation. However, several pediatricians believe that influenza virus infection does not exacerbate bronchial asthma, except for influenza A H1N1 2009 pandemic [A(H1N1)pdm09] virus infection. We previously reported that A(H1N1)pdm09 infection possibly induces severe pulmonary inflammation or severe asthmatic attack in a mouse model of bronchial asthma and in asthmatic children. However, the ability of seasonal H1N1 influenza (H1N1) infection to exacerbate asthmatic attacks in bronchial asthma patients has not been previously reported, and the differences in the pathogenicity profiles, such as cytokine profiles, remains unclear in bronchial asthma patients after A(H1N1)pdm09 and H1N1 infections.
METHODS: The cytokine levels and viral titers in the bronchoalveolar lavage (BAL) fluid from mice with and without asthma after H1N1 infection (A/Yamagata and A/Puerto Rico strains) were compared.
RESULTS: The interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-?, IL-5, interferon (IFN)-?, IFN-?, and IFN-? levels were significantly higher in the BAL fluids from the control/H1N1 mice than from the asthmatic/H1N1 mice. The viral titers in the BAL fluid were also significantly higher in the control/H1N1mice than in the asthmatic/H1N1 mice infected with either A/Yamagata or A/Puerto Rico.
CONCLUSIONS: A(H1N1)pdm09 infection, but not H1N1 infection, can induce severe pulmonary inflammation through elevated cytokine levels in a mouse model of asthma.

PMID: 24998935 [PubMed – as supplied by publisher]

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Intravenous Ketamine for Refractory Bronchospasm Precipitated by H1N1 Infection.

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Intravenous Ketamine for Refractory Bronchospasm Precipitated by H1N1 Infection.

Front Pediatr. 2014;2:24

Authors: Agrawal A, Shrivastava J

Abstract
Acute severe bronchospasm is an emergency situation and sometimes these children may fail to respond to conventional treatment and deteriorate rapidly to respiratory failure requiring mechanical ventilation. We present a case of 2-year-old girl, who presented with severe bronchospasm resulting in respiratory failure not responding to conventional management including mechanical ventilation and was found to be H1N1 positive. She was treated with ketamine infusion, which led to prompt improvement in airway obstruction.

PMID: 24765619 [PubMed]

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Improved Outcomes for Asthmatics With H1N1 Pandemic Flu – Medscape


MedIndia

Improved Outcomes for Asthmatics With H1N1 Pandemic Flu
Medscape
The study found that H1N1 patients with a history of asthma had better outcomes than nonasthmatics. "We found that those with asthma were half as likely to die or to need intensive care as other groups. We wanted to investigate this paradox," he said.
Swine Flu Death Rate Low in People Hospitalized With AsthmaMedIndia

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Clinical features and outcome of hospitalised adults and children with the 2009 influenza A H1N1 infection at Geneva’s University Hospital.

Clinical features and outcome of hospitalised adults and children with the 2009 influenza A H1N1 infection at Geneva’s University Hospital.

Swiss Med Wkly. 2011;141:w13177

Authors: Lücker LM, Kherad O, Iten A, Wagner N, Descombes M, Camus V, Kaiser L, Louis-Simonet M

To describe the clinical features and outcomes of hospitalised cases of the 2009 influenza A H1N1 virus infection at Geneva’s University Hospital during the peak of the epidemic.

PMID: 21416409 [PubMed – in process]

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Inactivated H1N1 vaccine safe, immunogenic in patients with asthma – American Pharmacists Association, pharmacist.com

Inactivated H1N1 vaccine safe, immunogenic in patients with asthma
American Pharmacists Association, pharmacist.com
Key points: A single 15-µg dose of inactivated H1N1 vaccine is safe and induces a strong immunogenic response in most patients with asthma, according to a study recently published in the Journal of Allergy and Clinical Immunology.

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People with severe asthma need higher dose of H1N1 vaccine:Study – Oneindia


MedIndia

People with severe asthma need higher dose of H1N1 vaccine:Study
Oneindia
H1N1 influenza vaccine in people with asthma indicates that a single dose of vaccine was safe and induced a strong immune response predictive of protection.
2009 H1N1 Vaccine Safe and Induced Robust Immune Response in People with AsthmaKansas City infoZine
Study finds older people with severe asthma need higher H1N1 vaccine dosePhysOrg.com
Flu season: Older people with severe asthma need higher H1N1 vaccine doseFreeport Journal-Standard
BioScholar News
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Older asthma patients may need higher H1N1 vaccine dose – VaccineNewsDaily

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