hardtocontrol Archives - World Asthma Foundation

January 24, 2012January 25, 2012

Heartburn and Acid Reflux Drug Does Not Improve Asthma in Children

Asthma and gastroesophageal reflux (GER) are both common illnesses in children. GER in children often occurs without the typical symptoms of heartburn, and physicians frequently prescribe the acid reflux drug lansoprazole to supplement the standard inhaled steroid treatment for children with uncontrolled asthma regardless of GER symptoms. However, a randomized clinic trial conducted by the American Lung Association’s Asthma Clinical Group found that the addition of lansoprazole does not improve asthma symptoms or the control of asthma in children and may increase the risk for upper respiratory infections and other adverse events.

Lansoprazole belongs to a class of drugs called proton pump inhibitors (PPIs) that reduce acid in the stomach. Use of these drugs, including for the treatment of asthma symptoms, has risen dramatically in children over the last decade.

“The data were very clear. Lansoprazole did not improve asthma symptoms in children as compared to a placebo, and there is no evidence to support prescribing these drugs to treat asthma in children,” said Janet Holbrook, PhD, corresponding author of the study and associate professor in the Department of Epidemiology at the Johns Hopkins Bloomberg School of Public Health. “In our study, children taking lansoprazole showed an increased risk for respiratory infection, sore throats and bronchitis.” The Bloomberg School’s Center for Clinical Trials served as data coordinating center for the research team.

For the study, researchers from 18 trial sites studied 306 children ages 6 to 17 years. All study participants had inadequately controlled asthma despite taking inhaled corticosteroids but did not have the typical symptoms of GER. Approximately 40 percent of participants were identified as having GER based on diagnostic testing. The participants were randomly selected to receive either a daily dose of lansoprazole or a placebo pill over a 24-week period in addition to their inhaled steroid therapy.

The researchers found no significant differences in severity of asthma symptoms or overall lung function between the group taking lansoprazole and the group receiving the placebo, including in the children positively identified as having GER. An earlier separate study of adults conducted by the same research team showed similar results.

September 23, 2010September 23, 2010

National Study Shows Drug Effective for Hard-to-Control Asthma – WMTV

Information from the University of Wisconsin Hospital and Clinics:

National Study Shows Drug Effective for Hard-to-Control Asthma

Madison, Wis. – An already available drug eases asthma in patients whose breathing problems persist while using inhaled corticosteroids, according to study results released this week.

University of Wisconsin-Madison researchers who were part of the trial say the ability to prescribe tiotropium bromide – which is already prescribed for chronic obstructive pulmonary disease (COPD) under the brand name Spiriva – adds another weapon to the fight against asthma.

“This is good news because sometimes patients don’t respond to low doses of inhaled corticosteroids, and raising the dose doesn’t always work, either,’’ says Dr. Christine Sorkness, professor of pharmacy at the UW School of Pharmacy. “This gives physicians another option for patients whose asthma is not being adequately controlled.”

Sorkness and Dr. Robert Lemanske, professor of pediatrics and medicine and head of the UW division of pediatric allergy, immunology, and rheumatology at the UW School of Medicine and Public Health, led the UW part of the trial, which enrolled 21 of the 210 adults who took part in the national study. Study results are being released this week in the New England Journal of Medicine and at the Annual Congress of the European Respiratory Society in Barcelona, Spain.

The National Heart, Lung, and Blood Institute (NHLBI) supported the study, which compared three tactics for treating uncontrolled asthma. In one treatment, participants received a doubled dose of inhaled corticosteroids; in the second, inhaled corticosteroids were supplemented by a long-acting beta-agonist (salmeterol); and in the third, the inhaled corticosteroids were supplemented with a long-acting anticholinergic drug (tiotropium bromide). Anticholinergics block the nerves that tighten the muscles around the lungs’ airways whereas beta-agonists relax the muscles lining the breathing passages of the lungs.

Before the trial, the patients averaged 77 days per year when their asthma was under control and they didn’t need to use their albuterol rescue inhalers. Doubling corticosteroids gave patients another 19 symptom-free days on average, while adding tiotropium to low-dose corticosteroids gave them another 48, similar to the improvement they had on corticosteroids plus salmeterol. But increasing corticosteroids and using beta- agonists both have risks,

“This is the first study to explore adding an anticholinergic inhaler to low-dose inhaled corticosteroids,” said Dr. James Kiley, director of the NHLBI’s division of lung diseases. “The Asthma Clinical Research Network is designed to address exactly these kinds of practical and important management questions, with the ultimate goal of helping asthma patients.”

In addition to UW-Madison, other members of the Asthma Clinical Research Network who took part in this trial include: Brigham and Women’s Hospital, Boston; Columbia University, New York City; Duke University, Durham, N.C.; The University of Texas Medical Branch at Galveston; National Jewish Medical and Research Center, Denver; University of California, San Diego; University of California, San Francisco; Washington University School of Medicine, St. Louis; and Wake Forest University. The data coordinating center is at Penn State College of Medicine in Hershey, Pa.

September 21, 2010