New drug target for asthma and allergies disclosed – HealthJockey.com

New drug target for asthma and allergies disclosed
HealthJockey.com
Allergies like asthma are very common which calls for even more therapeutic alternatives, other the ones used presently. Something known as histamine releasing factor (HRF) molecule is what experts from the La Jolla Institute for Allergy and Immunology
Uncovering Asthma and Allergy TriggersdailyRx
Asthma And Allergies – HRF Molecule Is A Promising Target For TreatmentMedical News Today

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Genetic clue to asthma disclosed: Research – HealthJockey.com

Genetic clue to asthma disclosed: Research
HealthJockey.com
Asthma is strikingly common and professionals believe that locating the exact cause may aid in developing new treatment strategies. More recently, researchers from the Lung Institute of WA (LIWA) have seemingly disclosed 2 new genetic variants that
New Genetic Variants = Treatment for AsthmaIvanhoe

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Prenatal smoking presumably linked to severe childhood asthma – HealthJockey.com


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Prenatal smoking presumably linked to severe childhood asthma
HealthJockey.com
Now, as per a study conducted by the University of California scientists, children suffering from prolonged asthma are apparently 3.6 folds likely to have faced exposure to tobacco smoking prior to birth. This seems to be true even if they were not
Study Reveals Deep Link between Smoking While Pregnant and AsthmaThe Bay Citizen (blog)
Smoking During Pregnancy Linked to Persistent Asthma in ChildhoodUCSF News Services
Prenatal exposure to smoke linked to severe asthma symptomshealthycal.org
WOWT
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EMF exposure during pregnancy apparently triggers asthma risk in offspring – HealthJockey.com


Health Newstrack

EMF exposure during pregnancy apparently triggers asthma risk in offspring
HealthJockey.com
Nearly a month back we heard that depression during pregnancy may lead to childhood asthma. More recently, a study conducted by Kaiser Permanente scientists has revealed that children of pregnant women exposed to magnetic fields (EMF) seemingly have to
Exposure to magnetic fields during pregnancy leads to asthma in offspringHealth Newstrack

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View full post on asthma – Google News

Asthma and Gastric Bacterium Helicobacter Pylori

Gastric bacterium Helicobacter pylori protects against asthma Says new Study

Infection with the gastric bacterium Helicobacter pylori provides reliable protection against allergy-induced asthma, immunologists from the University of Zurich have demonstrated in an animal model together with allergy specialists from the University Medical Center of the Johannes Gutenberg University Mainz. Their results published in the prestigious Journal of Clinical Investigation confirm the hypothesis recently put forward that the dramatic increase in allergic diseases in industrial societies is linked to the rapid disappearance of specific micro-organisms that populate the human body.

Allergy-induced asthma has been on the increase in the industrialized world for decades and has virtually taken on epidemic proportions. The rapid rise in allergic airway disease is attributed to air pollution, smoking, the hygiene hypothesis and the widespread use of antibiotics. The hygiene hypothesis states that modern hygiene measures have led to a lack of exposure to infectious agents, which is important for the normal maturation of the immune system. In an article published in the Journal of Clinical Investigation, scientists from the University of Zurich and the University Medical Center of the Johannes Gutenberg University Mainz now reveal that the increase in asthma could be put down to the specific disappearance of the gastric bacterium Helicobacter pylori (H. pylori) from Western societies.

H. pylori is resistant to gastric acid. According to estimates, around half of the world’s population might be infected with the bacteria. The affliction often has no symptoms, but under certain conditions can cause gastritis, gastric and duodenal ulcers, and stomach cancer. Consequently, H. pylori is often killed off with antibiotics as a precaution, even if the patient does not have any complaints.

Early infection with H. pylori protects against asthma

For their study, the researchers infected mice with H. pylori bacteria. If the mice were infected at the age of a few days old, they developed immunological tolerance to the bacterium and even reacted insignificantly – if at all – to strong, asthma-inducing allergens. Mice that were not infected with H. pylori until they had reached adulthood, however, had a much weaker defense. “Early infection impairs the maturation of the dendritic cells and triggers the accumulation of regulatory T-cells that are crucial for the suppression of asthma,” says Anne Müller, a professor of molecular cancer research at the University of Zurich, explaining the protective mechanism.

If regulatory T-cells were transferred from infected to uninfected mice, they too enjoyed effective protection against allergy-induced asthma. However, mice that had been infected early also lost their resistance to asthma-inducing allergens if H. pylori was killed off in them with the aid of antibiotics after the sensitization phase. According to lung and allergy specialist Christian Taube, a senior physician at III. Medical Clinic of the Johannes Gutenberg University Mainz, the new results confirm the hypothesis that the increase in allergic asthma in industrial nations is linked to the widespread use of antibiotics and the subsequent disappearance of micro-organisms that permanently populate the human body: “The study of these fundamental mechanisms is extremely important for us to understand asthma and be able to develop preventative and therapeutic strategies later on.”

Contact: Anne Mueller
mueller@imcr.uzh.ch
41-446-353-474
University of Zurich