Tag: healthy

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Ventilation/perfusion ratio and right to left shunt in healthy newborn infants.

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Ventilation/perfusion ratio and right to left shunt in healthy newborn infants.

J Clin Monit Comput. 2016 Dec 23;:

Authors: Dassios T, Ali K, Rossor T, Greenough A

Abstract
Oxygenation impairment can be assessed non-invasively by determining the degree of right-to-left shunt and ventilation/perfusion (VA/Q) inequality. These indices have been used in sick newborn infants, but normative values have not been reported which are essential to determine the magnitude of the abnormality. We, therefore, aimed to measure the shunt and VA/Q in infants with no history of respiratory conditions and determine if there was any effect of supine or prone position and the reproducibility of the data. Data were analysed from infants who had undergone a hypoxic challenge and in a subset who had been assessed in the supine or prone position. Transcutaneous oxygen saturations (SpO2) were recorded at fractions of inspired oxygen (FIO2) of 0.21 and 0.15. Two independent raters used a computer software algorithm which analysed and fitted paired data for FIO2 and SpO2 and derived a curve which represented the best fit for each infant’s data and calculated the shunt and VA/Q. The raters ability to interpret the SpO2 value which corresponded to a given FIO2 was compared. The downwards displacement of the FIO2 versus SpO2 curve was used to estimate the degree of right-to-left shunt and the rightwards shift of the curve was used to calculate the VA/Q ratio. The mean (SD) gestational age of the 145 infants was 39 (1.6) weeks, their birth weight was 2990 (578) gms and median (range) postnatal age at measurement 3 (1-8) days. The mean (SD) VA/Q ratio was 0.95 (0.21). None of the infants had a right-to-left shunt. No significant differences were found in VA/Q in the supine compared to the prone position. The intraclass correlation coefficient of VA/Q between two independent raters was 0.968 (95% CI 0.947-0.980), p?<?0.001. Right-to-left shunt and VA/Q ratio in healthy newborn infants were similar in the prone compared to the supine position.

PMID: 28012013 [PubMed – as supplied by publisher]

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A Study to Assess the Effect of Particle Size of AZD7594 on Pharmacokinetics (PK) After a Single Inhaled Dose When Administered Using the Dry Powder Inhaler in Healthy Volunteers.

Condition:   Asthma, Chronic Obstructive Pulmonary Disease (COPD)
Interventions:   Drug: Treatment A – AZD7594;   Drug: Treatment B – AZD7594;   Drug: Treatment C – AZD7594
Sponsor:   AstraZeneca
Not yet recruiting – verified October 2016

View full post on ClinicalTrials.gov: asthma | Studies received in the last 14 days

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A Study to Assess the Effect of Particle Size of AZD7594 on Pharmacokinetics After a Single Inhaled Dose When Administered Using the Dry Powder Inhaler in Healthy Volunteers.

Condition:   Asthma, Chronic Obstructive Pulmonary Disease (COPD)
Interventions:   Drug: Treatment A – AZD7594;   Drug: Treatment B – AZD7594;   Drug: Treatment C – AZD7594
Sponsor:   AstraZeneca
Not yet recruiting – verified October 2016

View full post on ClinicalTrials.gov: asthma | Studies received in the last 14 days

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Adult-Onset Asthma: Are You at Risk? – Healthy Magazine


Healthy Magazine

Adult-Onset Asthma: Are You at Risk?
Healthy Magazine
Asthma is often thought of as a condition that mainly affects children, like chicken pox. While many people first develop asthma during childhood, the signs and symptoms of asthma can actually pop up at any point during your life. Symptoms can appear …
Asthma Triggers To Avoid This SpringThe Milwaukee Community Journal
Asthma Survey Reports Most Patients Think Disease Is Controlled, but It's NotLung Disease News
Suffering seasonal allergies, Boise? Cottonwood is likely culpritIdaho Statesman
Everyday Health (blog) –Healio –SurfKY News (registration) (blog)
all 20 news articles »

View full post on asthma – Google News

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Post-vaccination myositis and myocarditis in a previously healthy male.

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Post-vaccination myositis and myocarditis in a previously healthy male.

Allergy Asthma Clin Immunol. 2016;12:6

Authors: Cheng MP, Kozoriz MG, Ahmadi AA, Kelsall J, Paquette K, Onrot JM

Abstract
BACKGROUND: The immunological literature has been redefining clinical phenomena as hypotheses emerge regarding causal links between triggers, immunologic manifestations, and their specific inflammatory cascades. Of late, autoimmune manifestations that appear to be caused by an external adjuvant have been grouped into a complex syndrome referred to as autoimmune/inflammatory syndrome induced by adjuvants (ASIA). This syndrome may present with diverse clinical problems, which may include neurocognitive impairment, inflammatory musculoskeletal changes, and constitutional symptoms. There is evidence in the literature linking vaccines to different auto-immune manifestations. Vaccines have not traditionally been reported to trigger ASIA, although reports are emerging linking the human papilloma virus and hepatitis B vaccines to it.
CASE PRESENTATION: We report the first suspected case of ASIA in a previously healthy patient who received the Fluad seasonal influenza vaccine, which contains the MF59 adjuvant. He presented to hospital with profound weakness and was diagnosed with severe rhabdomyolysis. He also had elevated troponin-I and extensive cardiac investigations enabled the diagnosis of myocarditis. His infectious and rheumatologic work-ups were negative. He responded well to conservative management and did not require immune suppressive therapy.
CONCLUSION: Given the benefits of the influenza vaccine, and the low incidence of clinically significant complications, we encourage ongoing seasonal influenza immunization. However, ongoing surveillance is required to evaluate the occurrence of rare adverse events, including ASIA.

PMID: 26877725 [PubMed]

View full post on pubmed: asthma

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A Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD7594 Inhaled Formulation in Healthy Japanese Men

Conditions:   Asthma;   Chronic Obstructive Pulmonary Disease (COPD)
Interventions:   Drug: AZD7594 inhalation powder (200 ?g);   Drug: AZD7594 inhalation powder (400 ?g);   Drug: AZD7594 pressurized inhalation suspension (200 ?g);   Drug: AZD7594 placebo inhalation powder;   Drug: AZD7594 placebo pressurized inhalation suspension
Sponsor:   AstraZeneca
Not yet recruiting – verified December 2015

View full post on ClinicalTrials.gov: asthma | received in the last 14 days

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Children and adult mentors pledged to healthy habits, learn about asthma triggers – Peoria Journal Star


Peoria Journal Star

Children and adult mentors pledged to healthy habits, learn about asthma triggers
Peoria Journal Star
The campaign is the students' Public Relations Senior Capstone Project that focuses on preventing asthma by adopting healthy habits like eating well and exercising. The program included activities such as hearing local nurses speak about healthy living …

View full post on asthma – Google News