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Pneumonia in Early Childhood Tied to Higher Odds of Asthma
HealthDay FRIDAY, March 6, 2015 (HealthDay News) — Children who contract pneumonia during the first three years of life appear to face a higher risk of developing asthma, new research suggests. These findings raise concern that early childhood respiratory … |
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Teen girls from rural areas have undiagnosed asthma, face higher risk of …
News-Medical.net Teen girls who live in rural areas are more likely than their male counterparts to have undiagnosed asthma, and they often are at a higher risk of depression, according to researchers at the Medical College of Georgia at Georgia Regents University … |
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Undifferentiated Bronchial Fibroblasts Derived from Asthmatic Patients Display Higher Elastic Modulus than Their Non-Asthmatic Counterparts.
PLoS One. 2015;10(2):e0116840
Authors: Sarna M, Wojcik KA, Hermanowicz P, Wnuk D, Burda K, Sanak M, Czy? J, Michalik M
Abstract
During asthma development, differentiation of epithelial cells and fibroblasts towards the contractile phenotype is associated with bronchial wall remodeling and airway constriction. Pathological fibroblast-to-myofibroblast transition (FMT) can be triggered by local inflammation of bronchial walls. Recently, we have demonstrated that human bronchial fibroblasts (HBFs) derived from asthmatic patients display some inherent features which facilitate their FMT in vitro. In spite of intensive research efforts, these properties remain unknown. Importantly, the role of undifferentiated HBFs in the asthmatic process was systematically omitted. Specifically, biomechanical properties of undifferentiated HBFs have not been considered in either FMT or airway remodeling in vivo. Here, we combine atomic force spectroscopy with fluorescence microscopy to compare mechanical properties and actin cytoskeleton architecture of HBFs derived from asthmatic patients and non-asthmatic donors. Our results demonstrate that asthmatic HBFs form thick and aligned ‘ventral’ stress fibers accompanied by enlarged focal adhesions. The differences in cytoskeleton architecture between asthmatic and non-asthmatic cells correlate with higher elastic modulus of asthmatic HBFs and their increased predilection to TGF-?-induced FMT. Due to the obvious links between cytoskeleton architecture and mechanical equilibrium, our observations indicate that HBFs derived from asthmatic bronchi can develop considerably higher static tension than non-asthmatic HBFs. This previously unexplored property of asthmatic HBFs may be potentially important for their myofibroblastic differentiation and bronchial wall remodeling during asthma development.
PMID: 25679502 [PubMed – as supplied by publisher]
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Medscape |
Asthma Tied to Higher Risk of Sleep Apnea
WebMD The finding stems from the long-term tracking of about 550 men and women, of whom a little over 15 percent had asthma. All were participants in the Wisconsin Sleep Cohort Study. At the study's launch in 1988, all the enrollees were between the ages of … Asthma Linked to New-Onset Sleep Apnea Study finds that asthma may increase obstructive sleep apnea risk Asthma linked to risk of new-onset obstructive sleep apnea |
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Medical Xpress |
Asthma Tied to Higher Risk of Sleep Apnea
U.S. News & World Report TUESDAY, Jan. 13, 2015 (HealthDay News) — Two troublesome adult breathing issues — asthma and sleep apnea — may have a connection, a new study suggests. Adults who struggle with asthma face an increased risk for also developing the nighttime … Asthma associated with increased risk of obstructive sleep apnea Asthma may add to sleep apnea risk Sleep on It: Asthma Tied to Sleep Breathing Problems |
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STLtoday.com |
XX Files: Older women with asthma at higher risk for death
STLtoday.com In addition, in 2009, the Asthma and Allergy Foundation of America named St. Louis at the top of its “Asthma Capitals” list, which ranks the most challenging cities to live in with asthma. And although St. Louis did not make it to the top of its most … |
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Medical News Today |
Study: Asthma risk higher for toddlers who share bed with parents
Poughkeepsie Journal Children who shared a bed with their parents during infancy (2 months old) did not have an increased risk of developing asthma by the time they were 6 years old. However, children who shared a bed with their parents when they were toddlers (age 24 … Bed-sharing toddlers 'more likely to develop asthma in later childhood' Toddlers who share bed with parents 'have a higher risk of asthma' Study Links Bed-sharing With Toddlers And An Increased Risk of Asthma |
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Daily Mail |
Higher rate of asthma seen in toddlers who share a bed with their parents
Medical Xpress This finding could suggest that, rather than bed-sharing causing asthma, parents may take the decision to share a bed with their child if they notice asthma symptoms as a way of monitoring their children. However, this hypothesis was not confirmed by … Bed-sharing toddlers in asthma link Toddlers sharing a bed with parents 'risk asthma' Asthma linked to bed-sharing by toddlers |
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Patients with Active Asthma at Higher Risk for Heart Attack, Mayo Clinic …
Newswise (press release) Newswise — CHICAGO — Patients with active asthma — such as any use of asthma medications, and unscheduled office or emergency visits for asthma — are at a twofold risk of having a heart attack, according to Mayo Clinic research presented at the … |
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Medical Xpress |
New studies link asthma to higher risk of heart disease
Milwaukee Journal Sentinel People who are treated for asthma are at substantially higher risk of developing cardiovascular disease, according to two research papers presented Sunday. However, researchers don't know whether it is asthma or asthma medications that are behind the … Asthma Raises Heart Attack Risk, Research Suggests Patients with active asthma at higher risk for heart attack, research shows Asthma May Put the Heart in Peril |
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