Condition: Asthma
Intervention:
Sponsor: University of California, San Francisco
Not yet recruiting – verified June 2016
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
Evolution of exhaled nitric oxide levels throughout development and aging of healthy humans.
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Evolution of exhaled nitric oxide levels throughout development and aging of healthy humans.
J Breath Res. 2015;9(3):036005
Authors: Jacinto T, Malinovschi A, Janson C, Fonseca J, Alving K
Abstract
It is not fully understood how the fraction of exhaled nitric oxide (FeNO) varies with age and gender in healthy individuals. We aim to describe the evolution of FeNO with age, giving special regard to the effect of gender, and to relate this evolution to natural changes in the respiratory tract.We studied 3081 subjects from NHANES 2007-08 and 2009-10, aged 6-80?years, with no self-reported diagnosis of asthma, chronic bronchitis or emphysema, and with normal values of blood eosinophils and C-reactive protein. The relationship of the mean values of FeNO to age, in all participants and divided by gender, was computed, and compared with changes in anatomic dead space volume and forced vital capacity. A change-point analysis technique and subsequent piecewise regression was used to detect breakpoints in the evolution of FeNO with age.Three distinct phases in the evolution of FeNO throughout the age range 6-80?years can be seen. FeNO values increase linearly between 6-14?years of age in girls and between 6-16?years of age in boys, in parallel with somatic growth. After that, FeNO levels plateau in both genders until age 45?years in females and age 59?years in males, when they start to increase linearly again. This increase continues until age 80.Our data clearly show a triphasic evolution of FeNO throughout the human age range in healthy individuals. This should be accounted for in development of reference equations for normal FeNO values.
PMID: 25993061 [PubMed – in process]
View full post on pubmed: asthma
Airway muscle-on-a-chip ‘simulates asthma in humans’ – Medical News Today
Headlines & Global News |
Airway muscle-on-a-chip 'simulates asthma in humans'
Medical News Today Asthma affects more than 300 million people worldwide and is responsible for around 250,000 deaths every year. It is also a leading cause of emergency room visits and hospitalization among children. There are a number of medications that can help … Airway Muscle-On-A-Chip Could Lead To Better Asthma Treatments Harvard-made lung muscle could yield asthma insights Airway muscle-on-a-chip mimics asthma |
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Lawmaker wants probe of EPA experiments on humans – Fox News
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Lawmaker wants probe of EPA experiments on humans
Fox News James Inhofe, R-Okla., called it “extremely disturbing” that EPA scientists may have exposed people with conditions such as asthma and a syndrome that puts them at higher risk for heart disease and strokes to concentrated, high levels of substances … EPA's Human Experiments, Salmonella Scare and Terrorists Extradited to the U.S. |
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Powerful lawmaker wants probe of EPA experiments on humans – Fox News
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Powerful lawmaker wants probe of EPA experiments on humans
Fox News called it “extremely disturbing” that EPA scientists may have exposed people with conditions such as asthma and a syndrome that puts them at higher risk for heart disease and strokes to concentrated, high levels of substances like fine particulate … |
View full post on asthma – Google News
Dog Bacteria Reduces Risk of Asthma in Humans, Says Science – Gizmodo
 The Atlantic |
Dog Bacteria Reduces Risk of Asthma in Humans, Says Science
Gizmodo New research suggests that exposure to certain microbes during infancy—particularly, to those from a particular strain of bacteria found in dogs—can alter the intestinal flora of a baby's developing GI tract such that asthmatic symptoms of a common … The Dog Bacteria That Protect You From Asthma Stanford School of Medicine |
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[Lipid composition of cells and low-density lipoproteins in blood serum of humans and some vertebrates species].
[Lipid composition of cells and low-density lipoproteins in blood serum of humans and some vertebrates species].
Zh Evol Biokhim Fiziol. 2011 Sep-Oct;47(5):365-74
Authors:
Abstract
To investigate interaction of atherogenic low-density lipoproteins (LDL) with erythrocytic membrane, the content of lipid components in blood cells and serum LDL was studied in human in norm (donors) and in 12 species of vertebrates (the mammals non-predisposed to atherosclerosis – birds and fish). Lipid composition of blood cells and LDL was analyzed also in patients with pathologies: ischemic heart disease (IHD), bronchial asthma (BA), and chronic obstructive bronchitis (COB), and in 2 species of mammals predisposed to atherosclerosis, in whose blood LDL predominates. The content of lipids in cells and LDL of the studied vertebrates has been found to depend on their taxonomy and the clear trends both to an increase of the cholesterol content and to a decrease if the phosphatidylcholine level in patients, particu- larly with IHD, and on a rise of the ratio of the content of the more saturated sphingomyelin and cholesterol to the less saturated phosphatidylcholine from the lower to the higher organisms, including humans (donors). The highest levels of free cholesterol in blood cells, of total cholesterol in LDL, and of ration of the cholesterol/phosphatidylcholine content have been revealed in patients, especially with 1HB, and in the mammals predisposed to atherosclerosis, i. e., in representatives with predominance of blood LDL, unlike donors and the mammals resistant to atherosclerosis. The highest parameters of lipid components were determined in cells and LDL inhuman with IHD. The lipid LDL composition affects directly the composition and ratio of lipids in blood cells.
PMID: 22145317 [PubMed – in process]
View full post on pubmed: asthma