New Imaging Method Could Improve Asthma Treatment – Drug Discovery & Development


Drug Discovery & Development

New Imaging Method Could Improve Asthma Treatment
Drug Discovery & Development
A team of researchers, led by the Universities of Cambridge and Birmingham, have used a laser beam trap to examine how drug particles from asthma inhalers behave as they are projected through the air. Their findings could improve the effectiveness of …

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View full post on asthma – Google News

Study to Compare the Effects of Z7200 And Symbicort® Turbohaler on Respiratory Imaging Parameters in Asthmatic Patients

Conditions:   Asthma;   Asthma Chronic;   Asthma Bronchial;   Asthmatic
Interventions:   Drug: Z7200;   Drug: Symbicort® Turbohaler®;   Drug: Placebo of Test product;   Drug: Placebo of Reference Drug;   Radiation: Functional Respiratory Imaging
Sponsors:   FluidDA nv;   Zambon SpA
Not yet recruiting – verified August 2014

View full post on ClinicalTrials.gov: asthma | received in the last 14 days

Comprehensive FISH Probe Design Tool Applied to Imaging Human Immunoglobulin Class Switch Recombination.

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Comprehensive FISH Probe Design Tool Applied to Imaging Human Immunoglobulin Class Switch Recombination.

PLoS One. 2012;7(12):e51675

Authors: Nedbal J, Hobson PS, Fear DJ, Heintzmann R, Gould HJ

Abstract
We present a web engine boosted fluorescence in-situ hybridization (webFISH) algorithm using a genome-wide sequence similarity search to design target-specific single-copy and repetitive DNA FISH probes. The webFISH algorithm featuring a user-friendly interface (http://www.webfish2.org/) maximizes the coverage of the examined sequences with FISH probes by considering locally repetitive sequences absent from the remainder of the genome. The highly repetitive human immunoglobulin heavy chain sequence was analyzed using webFISH to design three sets of FISH probes. These allowed direct simultaneous detection of class switch recombination in both immunoglobulin-heavy chain alleles in single cells from a population of cultured primary B cells. It directly demonstrated asynchrony of the class switch recombination in the two alleles in structurally preserved nuclei while permitting parallel readout of protein expression by immunofluorescence staining. This novel technique offers the possibility of gaining unprecedented insight into the molecular mechanisms involved in class switch recombination.

PMID: 23272136 [PubMed – in process]

View full post on pubmed: asthma

In vivo imaging of the airway wall in asthma: Fibered confocal fluorescence … – 7thSpace Interactive (press release)

In vivo imaging of the airway wall in asthma: Fibered confocal fluorescence
7thSpace Interactive (press release)
Airway remodelling is a feature of asthma including fragmentation of elastic fibres observed in the superficial elastin network of the airway wall. Fibered confocal fluorescence microscopy (FCFM) is a new and non-invasive imaging technique performed

View full post on asthma – Google News