Differences in fungi present in induced sputum samples from asthma patients … – 7thSpace Interactive (press release)

Differences in fungi present in induced sputum samples from asthma patients
7thSpace Interactive (press release)
There is emerging evidence for the presence of an extensive microbiota in human lungs. It is not known whether variations in the prevalence of species of microbiota in the lungs may have aetiological significance in respiratory conditions such as asthma.

View full post on asthma – Google News

Childhood asthma induced by maternal smoking may pass on to many generations – Newstrack India

Childhood asthma induced by maternal smoking may pass on to many generations
Newstrack India
Washington, October 16 (ANI): An Indian origin scientist was recently awarded a two-year, 377,220-dollar grant by the National Institutes of Health/National Institute of Child Health and Human Development to conduct a study that could potentially lead

View full post on asthma – Google News

Developmental Perturbation Induced by Maternal Asthma during Pregnancy: The Short- and Long-Term Impacts on Offspring.

Related Articles

Developmental Perturbation Induced by Maternal Asthma during Pregnancy: The Short- and Long-Term Impacts on Offspring.

J Pregnancy. 2012;2012:741613

Authors: Clifton VL, Davies M, Moore V, Wright IM, Ali Z, Hodyl NA

Abstract
Maternal asthma is a common disease to complicate human pregnancy. Epidemiological studies have identified that asthma during pregnancy increases the risk of a number of poor outcomes for the neonate including growth restriction, lower birthweight, preterm delivery, neonatal resuscitation, and stillbirth. Asthma therefore represents a significant health burden to society and could have an impact on the lifelong health of the children of women with asthma. Our research has identified that maternal asthma in pregnancy induces placental dysfunction and developmental perturbation in the fetus in a sex specific manner. These alterations in development could increase the risk of metabolic disease in adulthood of children of asthmatic mothers, especially females. In this paper, we will discuss the evidence currently available that supports the hypothesis that children of mothers with asthma may be at risk of lifelong health complications which include diabetes and hypertension.

PMID: 22830026 [PubMed – as supplied by publisher]

View full post on pubmed: asthma

Sphingosine-1-phosphate induced airway hyperreactivity in rodents is mediated by the S1P3 receptor.

Sphingosine-1-phosphate induced airway hyperreactivity in rodents is mediated by the S1P3 receptor.

J Pharmacol Exp Ther. 2012 May 8;

Authors: Trifilieff A, Fozard JR

Abstract
There is a need to better understand the mechanism of airway hyperreactivity, a key feature of asthma. Evidence suggests that sphingosine-1-phosphate (S1P) could be a major player in this phenomenon. The purpose of this work was to define the S1P receptor responsible for this phenomenon. We have studied, in the rat, the effect of two S1P synthetic receptor ligands, FTY720 (which in its phosphorylated form is a potent agonist at each S1P receptor except S1P2) and AUY954 (a highly selective S1P1 agonist) on lung function in vivo. This was complemented by in vitro studies using isolated trachea from the rat, the S1P3 receptor-deficient mouse and its wild type counterpart. Following oral administration, FTY720 induced a generalized airway hyperreactivity to a range of contractile stimuli. This was observed as early as one hour post dosing, lasted for at least 24 hours and was not subject to desensitization. In both the rat and wild type mouse isolated trachea, pre-incubation with the active phosphorylated metabolite of FTY720, induced hyperresponsiveness to 5-HT. This effect was not seen in the isolated tracheas from S1P3 receptor-deficient mice. AUY954, did not mimic the effect of FTY720 either in vivo or in vitro. Our data are consistent with activation of the S1P pathway inducing a generalized airway hyperreactivity in rats and mice that is mediated by the S1P3 receptor. S1P3 receptor antagonists might prove useful as new therapeutic strategies aimed at blocking the airway hyperreactivity observed in asthma.

PMID: 22570366 [PubMed – as supplied by publisher]

View full post on pubmed: asthma