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Active video game reduces lung inflammation in children with asthma
Healio Gomes and colleagues conducted a single blind, randomized controlled clinical trial over an 8 week period to determine if exercise that used an active video game system improved asthma control, airway inflammation and exercise capacity in children with … |
View full post on asthma – Google News
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Th2 biomarkers help identify inflammation in patients with asthma
Healio The analysis included 622 adults aged 18 to 65 years with partly or poorly controlled moderate to severe asthma. Researchers separated participants into two groups. The first group included participants (n = 237) with high airway reversibility … |
View full post on asthma – Google News
Condition: Asthma
Intervention: Dietary Supplement: Black seed oil
Sponsors: University College, London; King Abdulaziz University
Not yet recruiting – verified March 2015
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
Conditions: Rhinitis; Asthma; Inflammation; Hypersensitivity
Intervention:
Sponsor: Guangzhou Institute of Respiratory Disease
Recruiting – verified February 2015
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
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Docosahexaenoic acid ester of phloridzin inhibit lipopolysaccharide-induced inflammation in THP-1 differentiated macrophages.
Int Immunopharmacol. 2015 Jan 28;
Authors: Sekhon-Loodu S, Ziaullah, Rupasinghe HP
Abstract
Phloridzin or phlorizin (PZ) is a predominant phenolic compound found in apple and also used in various natural health products. Phloridzin shows poor absorption and cellular uptake due to its hydrophilic nature. The aim was to investigate and compare the effect of docosahexaenoic acid (DHA) ester of PZ (PZ-DHA) and its parent compounds (phloridzin and DHA), phloretin (the aglycone of PZ) and cyclooxygenase inhibitory drugs (diclofenac and nimesulide) on production of pro-inflammatory biomarkers in inflammation-induced macrophages by lipopolysaccharide (LPS)-stimulation. Human THP-1 monocytes were seeded in 24-well plates (5×10(5)/well) and treated with phorbol 12-myristate 13-acetate (PMA, 0.1?g/mL) for 48h to induce macrophage differentiation. After 48h, the differentiated macrophages were washed with Hank’s buffer and treated with various concentrations of test compounds for 4h, followed by the LPS-stimulation (18h). Pre-exposure of PZ-DHA ester was more effective in reducing tumor necrosis factor-alpha (TNF-?), interleukin-6 (IL-6) and cyclooxygenase-2 (COX-2) protein levels compared to DHA and nimesulide. However, diclofenac was the most effective in reducing prostaglandin (PGE2) level by depicting a dose-dependent response. However, PZ-DHA ester and DHA were the most effective in inhibiting the activation of nuclear factor-kappa B (NF-?B) among other test compounds. Our results suggest that PZ-DHA ester might possess potential therapeutic activity to treat inflammation related disorders such as type 2 diabetes, asthma, atherosclerosis and inflammatory bowel disease.
PMID: 25637769 [PubMed – as supplied by publisher]
View full post on pubmed: asthma
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Type 2 inflammation in asthma — present in most, absent in many
Nature.com In the version of this article that was originally published, the targeted epitope of lebrikizumab was listed as "IL?4R?" in Table 1 but this should be "IL?13 (IL?4Rz??binding epitope)". Also, for the main effects of lebrikizumab in human asthma trials … |
View full post on asthma – Google News
Lung Disease News |
Newly Discovered Toxin May Cause Lung Inflammation, Contribute to Asthma …
Lung Disease News On December 23, 2014, scientists from the University of Texas Health Science Center at San Antonio published a new study describing a novel way that a bacterial toxin might contribute to asthma and other pulmonary diseases, both chronic and acute. |
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Paeoniflorin attenuates allergic inflammation in asthmatic mice.
Int Immunopharmacol. 2014 Nov 26;
Authors: Sun J, Wu J, Xu C, Luo Q, Li B, Dong J
Abstract
Paeoniflorin (PF), one of the major active ingredients of Chinese peony, has demonstrated anti-inflammatory and immunoregulatory effects. However, it has remained unclear whether PF treatment can inhibit allergic inflammation in asthma. In this study, we evaluated the effects of PF on pulmonary function and airway inflammation in asthmatic mice. The allergic asthma models were established in BALB/c mice. The mice were sensitized and challenged with ovalbumin. Airway hyperresponsiveness was detected by direct airway resistance analysis. Lung tissues were examined for inflammatory cell infiltration. IL-5, IL-13, IL-17, and eotaxin in bronchoalveolar lavage fluid (BALF) and their mRNA expression in lung tissue were examined by ELISA and realtime PCR, respectively. The total IgE level in serum was measured by ELISA. The protein expression of p-ERK and p-JNK was detected by western blot. Our data showed that PF oral administration significantly reduced airway hyperresponsiveness to aerosolized methacholine and decreased IL-5, IL-13, IL-17 and eotaxin levels in the BALF, and decreased IgE level in the serum. Histological studies showed that PF administration markedly decreased inflammatory infiltration. Similarly, treatment with PF significantly inhibited IL-5, IL-13, IL-17 and eotaxin mRNA expression in lung tissues. The protein expression levels of p-ERK and p-JNK were substantially decreased after oral administration of PF. In summary, PF displayed anti-inflammatory effects in the OVA-induced asthmatic model by decreasing the expression of IL-5, IL-13, IL-17 and eotaxin. These effects were mediated at least partially by inhibiting the activation of MAPK pathway.
PMID: 25433342 [PubMed – as supplied by publisher]
View full post on pubmed: asthma
Condition: Asthma
Intervention: Biological: Segmental airway allergen challenge
Sponsors: University of California, San Francisco; National Institute of Allergy and Infectious Diseases (NIAID)
Not yet recruiting – verified August 2014
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
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Mycoplasma pneumoniae CARDS Toxin Exacerbates Ovalbumin-Induced Asthma-Like Inflammation in BALB/c Mice.
PLoS One. 2014;9(7):e102613
Authors: Medina JL, Coalson JJ, Brooks EG, Le Saux CJ, Winter VT, Chaparro A, Principe MF, Solis L, Kannan TR, Baseman JB, Dube PH
Abstract
Mycoplasma pneumoniae causes a range of airway and extrapulmonary pathologies in humans. Clinically, M. pneumoniae is associated with acute exacerbations of human asthma and a worsening of experimentally induced asthma in mice. Recently, we demonstrated that Community Acquired Respiratory Distress Syndrome (CARDS) toxin, an ADP-ribosylating and vacuolating toxin synthesized by M. pneumoniae, is sufficient to induce an asthma-like disease in BALB/cJ mice. To test the potential of CARDS toxin to exacerbate preexisting asthma, we examined inflammatory responses to recombinant CARDS toxin in an ovalbumin (OVA) murine model of asthma. Differences in pulmonary inflammatory responses between treatment groups were analyzed by histology, cell differentials and changes in cytokine and chemokine concentrations. Additionally, assessments of airway hyperreactivity were evaluated through direct pulmonary function measurements. Analysis of histology revealed exaggerated cellular inflammation with a strong eosinophilic component in the CARDS toxin-treated group. Heightened T-helper type-2 inflammatory responses were evidenced by increased expression of IL-4, IL-13, CCL17 and CCL22 corresponding with increased airway hyperreactivity in the CARDS toxin-treated mice. These data demonstrate that CARDS toxin can be a causal factor in the worsening of experimental allergic asthma, highlighting the potential importance of CARDS toxin in the etiology and exacerbation of human asthma.
PMID: 25058417 [PubMed – in process]
View full post on pubmed: asthma