Conditions: Asthma; COPD
Intervention:
Sponsor: Elpen Pharmaceutical Co. Inc.
Not yet recruiting – verified January 2014
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
Conditions: Asthma; COPD
Intervention:
Sponsor: Elpen Pharmaceutical Co. Inc.
Not yet recruiting – verified January 2014
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
Related Articles |
Influence of the Adjuvants and Genetic Background on the Asthma Model Using Recombinant Der f 2 in Mice.
Immune Netw. 2013 Dec;13(6):295-300
Authors: Chang YS, Kim YK, Jeon SG, Kim SH, Kim SS, Park HW, Min KU, Kim YY, Cho SH
Abstract
Der f 2 is the group 2 major allergen of a house dust mite (Dermatophagoides farinae) and its function has been recently suggested. To determine the optimal condition of sensitization to recombinant Der f 2 (rDer f 2) in murine model of asthma, we compared the effectiveness with different adjuvants in BALB/c and C57BL/6 mice. Mice from both strains sensitized with rDer f 2 by intraperitoneal injection or subcutaneous injection on days 1 and 14. The dosage was 20 µg. Freund’s adjuvants with pertussis toxin (FP) or alum alone were used as adjuvants. On days 28, 29, and 30, mice were challenged intranasally with 0.1% rDer f 2. We evaluated airway hyperresponsivenss, eosinophil proportion in lung lavage, airway inflammation, and serum allergen specific antibody responses. Naive mice were used as controls. Airway hyperresponsiveness was increased in C57BL/6 with FP, and BALB/c with alum (PC200: 13.5±6.3, 13.2±6.7 vs. >50 mg/ml, p<0.05). The eosinophil proportion was increased in all groups; C57BL/6 with FP, BALB/c with FP, C57BL/6 with alum, BALB/c with alum (24.8±3.6, 20.3±10.3, 11.0±6.9, 5.7±2.8, vs. 0.0±0.0%, p<0.05). The serum allergen specific IgE levels were increased in C57BL/6 with FP or alum (OD: 0.8±1.4, 1.1±0.8, vs. 0.0±0.0). C57BL/6 mice were better responders to rDer f 2 and as for adjuvants, Freund’s adjuvant with pertussis toxin was better.
PMID: 24385949 [PubMed]
View full post on pubmed: asthma
Air quality, genetics 'influence asthma'
Ninemsn Air quality, genetics 'influence asthma'. 11:42am March 15, 2013. Sydney's air pollution could boost the chances of developing childhood asthma, especially if children are already genetically predisposed to it, a study has found. Animals that choose … |
View full post on asthma – Google News
Latitude and UV-B exposure influence allergy and asthma risk
News-Medical.net In the study, both living closer to the equator and higher UV-B exposure were also associated with an increased risk for current asthma among atopic individuals and a reduced risk for current asthma among non-atopic individuals. "We found that latitude … |
View full post on asthma – Google News
Influence of asthma epidemiology on the risk for other diseases.
Allergy Asthma Immunol Res. 2012 May;4(3):122-31
Authors: Juhn YJ
Abstract
Asthma is a multifactorial chronic disease affecting a significant proportion of people in the United States and worldwide. Numerous laboratory and epidemiological studies have attempted to understand the etiology and underlying mechanisms of asthma and to identify effective therapies. However, the impact of asthma on the risk for other diseases has drawn little attention. This paper discusses the potential effects of asthma as a risk factor for other diseases, explores the potential mechanisms, and reviews the implications of the findings to clinical practice, public health, and research.
PMID: 22548204 [PubMed – in process]
View full post on pubmed: asthma
Study: Genetic ancestry has no influence on how African-Americans with asthma …
News-Medical.net Genetic ancestry has no discernible influence on how African American patients with asthma respond to medication, according to a Henry Ford Hospital study. … |
View full post on asthma – Google News