A Study Investigating the Immunologic Effects and Safety of 60-day Treatment of the ALK-Abello A/S, Originator or ALK HDM Tablets in Adult Subjects With Allergic Rhinitis and/or Atopic Asthma Induced by House Dust Mites (HDM)

Conditions:   Allergy;   Asthma;   Rhinitis
Interventions:   Drug: Mitizax;   Drug: Placebo
Sponsors:   Abbott;   Linical Co., Ltd;   Datamap
Recruiting – verified November 2015

View full post on ClinicalTrials.gov: asthma | received in the last 14 days

A Study Investigating the Immunologic Effects and Safety of 60-day Treatment of the ALK-Abello A/S, Originator or ALK HDM Tablets (ALK HDM Tablets) in Adult Subjects With Allergic Rhinitis and/or Atopic Asthma Induced by House Dust Mites (HDM)

Conditions:   Allergy;   Asthma;   Rhinitis
Interventions:   Drug: Mitizax;   Drug: Placebo
Sponsors:   Abbott;   Linical Co., Ltd;   Datamap
Recruiting – verified November 2015

View full post on ClinicalTrials.gov: asthma | received in the last 14 days

Investigating mutations of a crucial gene might assist treatment and … – Medical Xpress


Medical Xpress

Investigating mutations of a crucial gene might assist treatment and
Medical Xpress
Allergic asthma affects the lives of millions but new research may help to prevent or suppress an allergic response. Credit: Giorez/iStock/Thinkstock. Mutations in a specific gene are linked with human susceptibility to allergic asthma according to new

View full post on asthma – Google News

Investigating why asthma sufferers struggle with respiratory viruses – Medical News Today


Washington University in St. Louis News

Investigating why asthma sufferers struggle with respiratory viruses
Medical News Today
Asthma is a chronic disease that affects the airways in the lungs. These become inflamed and make breathing difficult during an asthma attack. We don't know for sure what causes asthma, except we know it can be triggered by allergens like pollen and
Study sheds light on asthma and respiratory virusesWashington University in St. Louis News
Study Sheds Light on Asthma, Respiratory VirusesBioscience Technology

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View full post on asthma – Google News

New study investigating impact of asthma on school children launches today – HealthCanal.com

New study investigating impact of asthma on school children launches today
HealthCanal.com
Asthma affects one in 11 children and young people in the UK. On average, this is two children in every classroom. Today scientists in East London are launching a new study to measure the impact asthma has on school children, with the aim of improving …

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View full post on asthma – Google News

Are mouse models of asthma appropriate for investigating the pathogenesis of airway hyper-responsiveness?

Are mouse models of asthma appropriate for investigating the pathogenesis of airway hyper-responsiveness?

Front Physiol. 2012;3:312

Authors: Kumar RK, Foster PS

Abstract
Whether mouse models of chronic asthma can be used to investigate the relationship between airway inflammation/remodeling and airway hyper-responsiveness (AHR) is a vexed question. It raises issues about the extent to which such models replicate key features of the human disease. Here, we review some of the characteristic pathological features of human asthma and their relationship to AHR and examine some limitations of mouse models that are commonly used to investigate these relationships. We compare these conventional models with our mouse model of chronic asthma involving long-term low-level inhalational challenge and review studies of the relationship between inflammation/remodeling and AHR in this model and its derivatives, including models of an acute exacerbation of chronic asthma and of the induction phase of childhood asthma. We conclude that while extrapolating from studies in mouse models to AHR in humans requires cautious interpretation, such experimental work can provide significant insights into the pathogenesis of airway responsiveness and its molecular and cellular regulation.

PMID: 23060800 [PubMed – in process]

View full post on pubmed: asthma