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Five recent FDA approvals and actions involving allergy, asthma
Healio Recent FDA actions have included the approval of fluticasone propionate 50 mcg spray for over-the-counter treatment of hay fever and upper respiratory allergy symptoms, as well as the acceptance of a new drug application for an albuterol multi-dose … |
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[Organ-invasive carcinoma of the pararenal gland involving the inferior vena cava].
Dtsch Med Wochenschr. 2013 Feb;138(6):260-5
Authors: Dillner J, Meyer F, Lippert H, Huth C, Klose S, Roessner A, Halloul Z
Abstract
History and admission findings: A 61-year-old woman presented with a 2-month-history of progressive deterioration, increasing exertional dyspnoea and pain in the right upper abdomen (past medical history: bronchial asthma and hypertension). The physical examination showed mild generalized weakness, tenderness in the right upper abdomen, and ascites.Investigations: Laboratory studies did not reveal any hormonal abnormalities. A CT angiogram revealed a mass of the right adrenal gland with distinct invasion into the inferior vena cava, and tumour thrombosis that extended proximally into the right atrium. Distally, the tumour ended at the caudate lobe of the liver with an extensive peripherally engulfed thrombus from the inferior vena cava down to the common iliac veins.Treatment and course: An open right adrenalectomy with resection of the periadrenal tissue and extirpation of the intracaval tumour thrombus (by cavotomy under digital occlusion of the blood flow from the vena cava into the right atrium) was carried out with no significant postoperative complications. Subsequently, the patient underwent adjuvant mitotane therapy for three years. So far, no recurrence has occurred during a course of 7 years.Conclusion: Tumour induced thrombotic occlusion of the inferior vena cava and other veins is rare, especially with right atrium involvement. In the absence of other effective treatment options, the combination of radical resection and adjuvant mitotane therapy remains the only successful curative treatment for primary invasive adrenal gland carcinoma.
PMID: 23361348 [PubMed – in process]
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