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The Epoch Times |
Secrets of Korean Medicine Part 6: Do You Think Asthma Is Curable?
The Epoch Times Asthma has become a very common chronic disease that affects more than 300 million people around the world. In the next 10 years, the number of people affected is expected to increase to 400 million. Daily in the United States, more than 40,000 people … |
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Atopic dermatitis is associated with Caesarean sections in Korean adolescents but asthma is not.
Acta Paediatr. 2015 Sep 12;
Authors: Yu M, Han K, Kim DH, Nam GE
Abstract
AIM: Studies on the associations between mode of delivery and allergic diseases have produced different results and research has rarely been conducted in Asian countries such as South Korea. This study assessed the relationship between mode of delivery and atopic dermatitis and asthma in Korean adolescents.
METHODS: Data collected from the Korea National Health and Nutrition Examination Survey between 2010 and 2011 were used. We included 1,302 adolescents aged from 12-18 years and multivariable logistic regression analysis was performed.
RESULTS: The odds ratio (OR) of having atopic dermatitis was 1.50, with a 95% confidence interval (95% CI) of 1.01-2.22, after adjusting for age and sex. The association remained significant after further adjustments for body mass index, breastfeeding and serum 25-hydroxyvitamin D level (OR = 1.61, 95% CI = 1.05-2.47) and when fat intake was added to those variables (OR = 1.80, 95% CI = 1.14-2.85). However, asthma was not associated with mode of delivery in any of the models.
CONCLUSIONS: Atopic dermatitis in adolescents was associated with Caesarean delivery, which is common in South Korea. The findings suggest that the frequency of this practice should be reconsidered and that further research with longitudinal evaluation of relevant mechanisms is needed. This article is protected by copyright. All rights reserved.
PMID: 26363368 [PubMed – as supplied by publisher]
View full post on pubmed: asthma
Condition: Asthma
Intervention: Procedure: bronchial thermoplasty system
Sponsor: Asan Medical Center
Not yet recruiting – verified January 2014
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
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Association Analysis Between FILIP1 Polymorphisms and Aspirin Hypersensitivity in Korean Asthmatics.
Allergy Asthma Immunol Res. 2013 Jan;5(1):34-41
Authors: Kim JY, Kim JH, Park BL, Pasaje CF, Bae JS, Park JS, Jang AS, Uh ST, Kim YH, Kim MK, Choi IS, Cho SH, Choi BW, Park CS, Shin HD
Abstract
PURPOSE: Aspirin exacerbated respiratory disease (AERD) results in a severe asthma attack after aspirin ingestion in asthmatics. The filamin A interacting protein 1 (FILIP1) may play a crucial role in AERD pathogenesis by mediating T cell activation and membrane rearrangement. We investigated the association of FILIP1 variations with AERD and the fall rate of forced expiratory volume in one second (FEV1).
METHODS: A total of 34 common FILIP1 single nucleotide polymorphisms (SNPs) were genotyped in 592 Korean asthmatic subjects that included 163 AERD patients and 429 aspirin-tolerant asthma (ATA) controls.
RESULTS: This study found that 5 SNPs (P=0.006-0.01) and 2 haplotypes (P=0.01-0.03) of FILIP1 showed nominal signals; however, corrections for the multiple testing revealed no significant associations with the development of AERD (P(corr)>0.05). In addition, association analysis of the genetic variants with the fall rate of FEV1, an important diagnostic marker of AERD, revealed no significant evidence (P(corr)>0.05).
CONCLUSIONS: Although further replications and functional evaluations are needed, our preliminary findings suggest that genetic variants of FILIP1 might be not associated with the onset of AERD.
PMID: 23277876 [PubMed – in process]
View full post on pubmed: asthma
Association between body mass index and asthma symptoms among korean children: a nation-wide study.
J Korean Med Sci. 2011 Dec;26(12):1541-7
Authors: Suh M, Kim HH, Choi DP, Kim KW, Sohn MH, Ha KH, Hwang WJ, Kim C, Kim KE, Shin DC
Abstract
The purpose of this study was to investigate the association between body mass index (BMI) and the prevalence of wheeze using nation-wide cross-sectional study in Korean children. Total 50,200 children from 427 elementary schools were randomly selected according to residential areas (metropolitan, provincial, rural, and industrial areas) by the cluster sampling method. The International Study of Asthma and Allergies in Childhood (ISAAC) questionnaires were used to measure the prevalence of wheeze. Among 31,026 respondents, 25,322 were analyzed. BMI was classified into quartiles based on BMI-for-age percentile. In all residential areas, pets at home and visible mold or moisture were associated with an increased prevalence of wheeze in both genders. However, other living environment factors were not consistently associated among residential areas and gender. Among girls, lowest BMI was negatively associated with prevalence of wheeze and highest BMI was positively associated in all residential areas. In multilevel logistic regression analysis, environmental tobacco smoking exposure, pets at home, visible mold or moisture, and being in the lowest and highest BMI quartile were significantly associated with the prevalence of wheeze in both genders. BMI has become an important risk factor for asthma symptoms among Korean children.
PMID: 22147989 [PubMed – in process]
View full post on pubmed: asthma