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Focus on lung health
The West Australian There are more than seven subtypes of asthma depending on whether the condition was related to a viral infection, environmental allergen, chemical interaction with medication, physical stimulation such as by exercise or cold air, or hormones. Anyone … |
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 OregonLive.com |
Wildfires cause tough conditions for those with asthma and other lung problems
OregonLive.com Follow health care providers' advice about prevention and treatment of symptoms, including using the full spectrum of prescribed medications. Those with an asthma action plan should follow it closely and monitor breathing and exposure to airborne matter. |
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Lung Association hopes pilot program will help lower incidence of asthma in …
St. Louis Beacon Two national groups have begun a public awareness campaign to reduce high levels of asthma in three zip codes in St. Louis. The locations, all on the city's north side, are among reasons St. Louis ranks 7th nationally in asthma, according to the two … |
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Chlamydia muridarum Lung Infection in Infants Alters Hematopoietic Cells to Promote Allergic Airway Disease in Mice.
PLoS One. 2012;7(8):e42588
Authors: Starkey MR, Kim RY, Beckett EL, Schilter HC, Shim D, Essilfie AT, Nguyen DH, Beagley KW, Mattes J, Mackay CR, Horvat JC, Hansbro PM
Abstract
BACKGROUND: Viral and bacterial respiratory tract infections in early-life are linked to the development of allergic airway inflammation and asthma. However, the mechanisms involved are not well understood. We have previously shown that neonatal and infant, but not adult, chlamydial lung infections in mice permanently alter inflammatory phenotype and physiology to increase the severity of allergic airway disease by increasing lung interleukin (IL)-13 expression, mucus hyper-secretion and airway hyper-responsiveness. This occurred through different mechanisms with infection at different ages. Neonatal infection suppressed inflammatory responses but enhanced systemic dendritic cell:T-cell IL-13 release and induced permanent alterations in lung structure (i.e., increased the size of alveoli). Infant infection enhanced inflammatory responses but had no effect on lung structure. Here we investigated the role of hematopoietic cells in these processes using bone marrow chimera studies.
METHODOLOGY/PRINCIPAL FINDINGS: Neonatal (<24-hours-old), infant (3-weeks-old) and adult (6-weeks-old) mice were infected with C. muridarum. Nine weeks after infection bone marrow was collected and transferred into recipient age-matched irradiated naïve mice. Allergic airway disease was induced (8 weeks after adoptive transfer) by sensitization and challenge with ovalbumin. Reconstitution of irradiated naïve mice with bone marrow from mice infected as neonates resulted in the suppression of the hallmark features of allergic airway disease including mucus hyper-secretion and airway hyper-responsiveness, which was associated with decreased IL-13 levels in the lung. In stark contrast, reconstitution with bone marrow from mice infected as infants increased the severity of allergic airway disease by increasing T helper type-2 cell cytokine release (IL-5 and IL-13), mucus hyper-secretion, airway hyper-responsiveness and IL-13 levels in the lung. Reconstitution with bone marrow from infected adult mice had no effects.
CONCLUSIONS: These results suggest that an infant chlamydial lung infection results in long lasting alterations in hematopoietic cells that increases the severity of allergic airway disease in later-life.
PMID: 22870337 [PubMed – in process]
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Lung association offers back-to-school tips for asthma management
Cape Gazette As summer sizzles by, families across the state are beginning to prepare for the new school year. A new school environment can sometimes be difficult for children with asthma. This back-to-school season, the American Lung Association in Delaware … Scientists: Third Hand Smoke Also a Danger Thirdhand smoke poses health risk |
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 BBC News |
Golden child: How Laura Trott overcame collapsed lung, asthma and sickness to …
Mirror.co.uk She took up the sport after her parents had been told as an asthmatic she would need to take part in sport to help regulate her breathing. Despite making cycling at speeds of up to 70km per hour look easy, Trott has a particularly high acid lining in … Trott's breathing easy Double gold for Trott Trott in race to be the new Queen Vicky |
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Related Articles |
Therapeutical Measures to Control Airway Tolerance in Asthma and Lung Cancer.
Front Immunol. 2012;3:216
Authors: Andreev K, Graser A, Maier A, Mousset S, Finotto S
Abstract
Airway tolerance is a specialized immunological surveillance which is activated by the cells of the lung to deal with and distinguish between innocuous and pathogenic inhalants. However, this distinction does not always occur. Airway tolerance is necessary to avoid the development of allergic disorders, such as asthma, which is dominated by a pathological expansion of Th2 and Th17 cells in the airways. By contrast, tumor cells induce tolerogenic factors in their microenvironment to evade T-cell mediated anti-tumor-immune responses. This review updates current understandings on the effect of the cytokines TGF-?, IL-10, and IL-17A on the lung immune responses to antigen, and analyzes their involvement in allergic asthma and lung cancer. The aim of the review is to evaluate where therapeutic intervention may be feasible and where it might fail. The multifunctional role of these cytokines further complicates the decision on the timing and concentration for their use as therapeutical targets. In fact, TGF-? has suppressive activity in early tumorigenesis, but may become tumor-promoting in the later stages of the disease. This dual behavior is sometimes due to changes in the cellular target of TGF-?, and to the expansion of the induced (i)-Tregs. Similarly, IL-17A has been found to elicit pro- as well as anti-tumor properties. Thus, this pro-inflammatory cytokine induces the production of IL-6 which interferes with Treg development. Yet IL-17A could promote tumor growth in conjunction with IL-6-dependent activation of Stat3. Thus, understanding the mechanisms of airway tolerance could help to improve the therapy to both, allergic asthma and lung cancer. Hereby, asthma therapy aims to induce and maintain tolerance to inhaled allergens and therapy against lung cancer tries to inhibit the tolerogenic response surrounding the tumor.
PMID: 22855687 [PubMed – as supplied by publisher]
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American Lung Association Stresses Back-to-School Checklist for Students with …
NJ TODAY “It's important that parents of students with asthma first consider their child's health and the time they spend under the supervision of school personnel and the school environment in preparing their child to go back to school,” said Albert Rizzo, M.D … |
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American Lung Association In New Jersey Stresses Back-to-School Checklist …
ParamusPost.com “It's important that parents of students with asthma first consider their child's health and the time they spend under the supervision of school personnel and the school environment in preparing their child to go back to school,” said Albert Rizzo, M.D … |
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 Cape Gazette |
American Lung Association hosts Asthma Camp
Cape Gazette The American Lung Association in Delaware hosted its annual Asthma Camp July 9 to 13 at St. Jude the Apostle Church in Lewes to educate young people with asthma on how to manage their disease. The camp provided an opportunity for boys and girls 7 to … |
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