Tag: lupus

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A link: Allergic rhinitis, Asthma & Systemic Lupus Erythematosus.

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A link: Allergic rhinitis, Asthma & Systemic Lupus Erythematosus.

Autoimmun Rev. 2016 Feb 3;

Authors: Sin E, Anand P, Frieri M

Abstract
This review has discussed a link between allergic rhinitis, asthma and systemic lupus erythematosus (SLE) and a case report in this area. A clear link with symptoms of allergic rhinitis, asthma and SLE exists. Several articles found on pubmed in the literature are listed on allergic rhinitis and allergy, Th1-immune responses, mast cells in autoimmunity, total immunoglobulin E levels in lupus, atopic diseases and SLE are reviewed. In addition, risks and correlations, genetic predisposition, environmental factors, immune regulation, elevated serum IgE levels, regulatory B cells for both allergic and autoimmune diseases are mentioned, Asthma and the vascular endothelial cell growth factor, asthma and autoimmune diseases, allergy and autoimmunity, neutrophils, innate and adaptive immunity in the development of SLE, the (Tim) gene family, complement activation in SLE and immunomodulation, hypersensitivity reactions in autoimmunity are discussed.

PMID: 26851551 [PubMed – as supplied by publisher]

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UPDATE 1-Arthritis, lupus and asthma data a shot in arm for AstraZeneca – Reuters


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UPDATE 1-Arthritis, lupus and asthma data a shot in arm for AstraZeneca
Reuters
Benralizumab and tralokinumab both showed improvements in control of asthma in patients with specific, severe forms of the breathing disorder. All the drugs are being developed by MedImmune, the U.S.-based biotech company acquired by AstraZeneca in …
Arthritis, lupus and asthma data a shot in arm for AstraZenecaYahoo News
AstraZeneca: Mavrilimumab Produces Rapid Improvement In Signs, Symptoms …Wall Street Journal
AstraZeneca Says MedImmune Phase II Trials Data PositiveLondon South East

all 8 news articles »

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Discovery Expected to Shift Research Direction in Lupus and Asthma – Science Daily (press release)

Discovery Expected to Shift Research Direction in Lupus and Asthma
Science Daily (press release)
"Considering that diseases from asthma to lupus can occur because the system mistakenly ramps up the same types of T cell responses it normally uses against worms, our finding that B lymphocytes control the T cell/dendritic cell interactions that …

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Discovery Expected to Shift Research Direction in Lupus and Asthma – Newswise (press release)

Discovery Expected to Shift Research Direction in Lupus and Asthma
Newswise (press release)
“Considering that diseases from asthma to lupus can occur because the system mistakenly ramps up the same types of T cell responses it normally uses against worms, our finding that B lymphocytes control the T cell/dendritic cell interactions that …

View full post on asthma – Google News

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Systemic lupus erythematosus: From mouse models to human disease and treatment

On Sept. 2-3, 2010, the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Cancer Institute (NCI), the National Institute of Allergy and Infectious Diseases (NIAID), and the NIH Office of Research on Women’s Health (ORWH) will convene a two-day conference on Systemic Lupus Erythematosus: From Mouse Models to Human Disease and Treatment. This meeting will bring together basic research scientists working on models of autoimmune disease relevant to systemic lupus erythematosus (SLE), with clinicians treating lupus patients. There are numerous mouse models of lupus, but their relevance to the actual disorder is still a subject for debate. Moreover, since SLE is a heterogeneous disease, some features of the disorder may be better reflected in one or another mouse model.

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