Charity event in memory of teenager of who died of asthma attack in Cleethorpes – Grimsby Telegraph


Grimsby Telegraph

Charity event in memory of teenager of who died of asthma attack in Cleethorpes
Grimsby Telegraph
The event, taking place at the North Lindsey College events centre tomorrow (Saturday) includes two hours of body combat and insanity to raise money for the charity Asthma UK. Alan Rayment, manager of the Kingsway Fitness Suite at North Lindsey College …
Alex all ready for herbig Marathon missionHorncastle News

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Differential gene network analysis for the identification of asthma-associated therapeutic targets in allergen-specific T-helper memory responses.

Differential gene network analysis for the identification of asthma-associated therapeutic targets in allergen-specific T-helper memory responses.

BMC Med Genomics. 2016;9(1):9

Authors: Troy NM, Hollams EM, Holt PG, Bosco A

Abstract
BACKGROUND: Asthma is strongly associated with allergic sensitization, but the mechanisms that determine why only a subset of atopics develop asthma are not well understood. The aim of this study was to test the hypothesis that variations in allergen-driven CD4 T cell responses are associated with susceptibility to expression of asthma symptoms.
METHODS: The study population consisted of house dust mite (HDM) sensitized atopics with current asthma (n?=?22), HDM-sensitized atopics without current asthma (n?=?26), and HDM-nonsensitized controls (n?=?24). Peripheral blood mononuclear cells from these groups were cultured in the presence or absence of HDM extract for 24 h. CD4 T cells were then isolated by immunomagnetic separation, and gene expression patterns were profiled on microarrays.
RESULTS: Differential network analysis of HDM-induced CD4 T cell responses in sensitized atopics with or without asthma unveiled a cohort of asthma-associated genes that escaped detection by more conventional data analysis techniques. These asthma-associated genes were enriched for targets of STAT6 signaling, and they were nested within a larger coexpression module comprising 406 genes. Upstream regulator analysis suggested that this module was driven primarily by IL-2, IL-4, and TNF signaling; reconstruction of the wiring diagram of the module revealed a series of hub genes involved in inflammation (IL-1B, NFkB, STAT1, STAT3), apoptosis (BCL2, MYC), and regulatory T cells (IL-2Ra, FoxP3). Finally, we identified several negative regulators of asthmatic CD4 T cell responses to allergens (e.g. IL-10, type I interferons, microRNAs, drugs, metabolites), and these represent logical candidates for therapeutic intervention.
CONCLUSION: Differential network analysis of allergen-induced CD4 T cell responses can unmask covert disease-associated genes and pin point novel therapeutic targets.

PMID: 26922672 [PubMed – as supplied by publisher]

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Hero asthma teen’s memory lives on with gift of life to three desperately ill children – Mirror.co.uk


Mirror.co.uk

Hero asthma teen's memory lives on with gift of life to three desperately ill children
Mirror.co.uk
A schoolboy who died after an asthma attack has given the gift of life to three desperately ill children. His family say he left them 'as a hero'. Tributes have flooded in for Luke Senior, who was put on a life support machine after he collapsed at his

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Mint Health Benefits: Fights Asthma, Memory Loss, Weight Loss – Youth Health Magzine


Youth Health Magzine

Mint Health Benefits: Fights Asthma, Memory Loss, Weight Loss
Youth Health Magzine
The herb decoction is an excellent remedy for minor ailments such as headaches, nervous strain, fatigue and stress, as well as for the respiratory problems; helping with asthma, bronchitis and catarrh. It is very useful to deal with digestive problems

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Belvedere fundraiser to walk 60 miles in memory of her mother and brother – News Shopper


Bexley Times

Belvedere fundraiser to walk 60 miles in memory of her mother and brother
News Shopper
Civil servant Caroline Witkowski, of Nuxley Road, will be travelling 62.1 miles from London to Brighton in May to raise cash for Asthma UK. The charity is one close to Caroline's heart, as the 29-year-old lost both her mother and brother to asthma.
Bereaved Belvedere mum takes on London to Brighton challengeBexley Times

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Father teaches children about the dangers of asthma in memory of son – St Albans & Harpenden Review

Father teaches children about the dangers of asthma in memory of son
St Albans & Harpenden Review
By Zoe Forsey » A father from St Albans who lost his son to asthma five years ago is marking the anniversary of his death with a campaign to teach people about the real dangers of the condition. Peter Curtis has been working hard to bring asthma and

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