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EPA admin sees Boston as model for asthma prevention
wwlp.com STATE HOUSE, BOSTON, AUG. 19, 2014…..Buoyed by fresh data that indicates its success, officials involved in a Boston program attacking asthma triggers in the home are hoping it will spread elsewhere, and have found common cause with Environmental … |
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Cytokine profile of bronchoalveolar lavage fluid from a mouse model of bronchial asthma during seasonal H1N1 infection.
Cytokine. 2014 Jul 3;69(2):206-210
Authors: Hasegawa S, Wakiguchi H, Okada S, Gui Kang Y, Fujii N, Hasegawa M, Hasegawa H, Ainai A, Atsuta R, Shirabe K, Toda S, Wakabayashi-Takahara M, Morishima T, Ichiyama T
Abstract
BACKGROUND: Several studies support the role of viral infections in the pathogenesis of asthma exacerbation. However, several pediatricians believe that influenza virus infection does not exacerbate bronchial asthma, except for influenza A H1N1 2009 pandemic [A(H1N1)pdm09] virus infection. We previously reported that A(H1N1)pdm09 infection possibly induces severe pulmonary inflammation or severe asthmatic attack in a mouse model of bronchial asthma and in asthmatic children. However, the ability of seasonal H1N1 influenza (H1N1) infection to exacerbate asthmatic attacks in bronchial asthma patients has not been previously reported, and the differences in the pathogenicity profiles, such as cytokine profiles, remains unclear in bronchial asthma patients after A(H1N1)pdm09 and H1N1 infections.
METHODS: The cytokine levels and viral titers in the bronchoalveolar lavage (BAL) fluid from mice with and without asthma after H1N1 infection (A/Yamagata and A/Puerto Rico strains) were compared.
RESULTS: The interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-?, IL-5, interferon (IFN)-?, IFN-?, and IFN-? levels were significantly higher in the BAL fluids from the control/H1N1 mice than from the asthmatic/H1N1 mice. The viral titers in the BAL fluid were also significantly higher in the control/H1N1mice than in the asthmatic/H1N1 mice infected with either A/Yamagata or A/Puerto Rico.
CONCLUSIONS: A(H1N1)pdm09 infection, but not H1N1 infection, can induce severe pulmonary inflammation through elevated cytokine levels in a mouse model of asthma.
PMID: 24998935 [PubMed – as supplied by publisher]
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Influence of the Adjuvants and Genetic Background on the Asthma Model Using Recombinant Der f 2 in Mice.
Immune Netw. 2013 Dec;13(6):295-300
Authors: Chang YS, Kim YK, Jeon SG, Kim SH, Kim SS, Park HW, Min KU, Kim YY, Cho SH
Abstract
Der f 2 is the group 2 major allergen of a house dust mite (Dermatophagoides farinae) and its function has been recently suggested. To determine the optimal condition of sensitization to recombinant Der f 2 (rDer f 2) in murine model of asthma, we compared the effectiveness with different adjuvants in BALB/c and C57BL/6 mice. Mice from both strains sensitized with rDer f 2 by intraperitoneal injection or subcutaneous injection on days 1 and 14. The dosage was 20 µg. Freund’s adjuvants with pertussis toxin (FP) or alum alone were used as adjuvants. On days 28, 29, and 30, mice were challenged intranasally with 0.1% rDer f 2. We evaluated airway hyperresponsivenss, eosinophil proportion in lung lavage, airway inflammation, and serum allergen specific antibody responses. Naive mice were used as controls. Airway hyperresponsiveness was increased in C57BL/6 with FP, and BALB/c with alum (PC200: 13.5±6.3, 13.2±6.7 vs. >50 mg/ml, p<0.05). The eosinophil proportion was increased in all groups; C57BL/6 with FP, BALB/c with FP, C57BL/6 with alum, BALB/c with alum (24.8±3.6, 20.3±10.3, 11.0±6.9, 5.7±2.8, vs. 0.0±0.0%, p<0.05). The serum allergen specific IgE levels were increased in C57BL/6 with FP or alum (OD: 0.8±1.4, 1.1±0.8, vs. 0.0±0.0). C57BL/6 mice were better responders to rDer f 2 and as for adjuvants, Freund’s adjuvant with pertussis toxin was better.
PMID: 24385949 [PubMed]
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New statistic model forecasts the effect of tobacco consumption on childhood …
YottaFire A scientific study recently published on International Journal of Statistics in Medical Research states that tobacco consumption must be decreased by 15% in Spain, particularly at home, in order to reduce the number of childhood asthma cases. The … |
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The Almagest |
New statistic model forecasts the effect of tobacco consumption on childhood …
The Almagest A scientific study published on International Journal of Statistics in Medical Research states that tobacco consumption must be decreased by 15% in Spain, particularly at home, in order to reduce the number of childhood asthma cases. The research is … |
View full post on asthma – Google News
The rabbit as a model for studying lung disease and stem cell therapy.
Biomed Res Int. 2013;2013:691830
Authors: Kamaruzaman NA, Kardia E, Kamaldin N’, Latahir AZ, Yahaya BH
Abstract
No single animal model can reproduce all of the human features of both acute and chronic lung diseases. However, the rabbit is a reliable model and clinically relevant facsimile of human disease. The similarities between rabbits and humans in terms of airway anatomy and responses to inflammatory mediators highlight the value of this species in the investigation of lung disease pathophysiology and in the development of therapeutic agents. The inflammatory responses shown by the rabbit model, especially in the case of asthma, are comparable with those that occur in humans. The allergic rabbit model has been used extensively in drug screening tests, and this model and humans appear to be sensitive to similar drugs. In addition, recent studies have shown that the rabbit serves as a good platform for cell delivery for the purpose of stem-cell-based therapy.
PMID: 23653896 [PubMed – in process]
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First model of how Sydney pollutants may drive childhood asthma
Medical Xpress "Developing a proper model of childhood asthma involves long-term studies and controlled exposure to triggers in the environment, which requires a great deal of effort and has not been done before," says UNSW Medicine's Professor Rakesh Kumar, the … |
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First model of how Sydney pollutants may drive childhood asthma
HealthCanal.com “Developing a proper model of childhood asthma involves long-term studies and controlled exposure to triggers in the environment, which requires a great deal of effort and has not been done before,” says UNSW Medicine's Professor Rakesh Kumar, the … |
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Success here model for care in nation
Cincinnati.com Jeremiah Reese, 7, is examined by Julie Malkin, a nurse practitioner at Children's Hospital. They're joined by Jeremiah's asthma care coordinator, Brandy Weiner. HHS Secretary Kathleen Sebelius cites Children's asthma care program as a national model. |
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Asthma sufferer Dynasty Reese, 10, was 'just a model student'
Omaha World-Herald Dynasty, 10, a fifth-grader at Conestoga, died May 10 at an Omaha hospital after a May 8 asthma attack at her home. Funeral services are at 11 am Friday at Salem Baptist Church, 3131 Lake St. Milan said Dynasty played volleyball at the school, … |
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