Asthma sufferers, young more prone to enterovirus – Jackson Clarion Ledger


Jackson Clarion Ledger

Asthma sufferers, young more prone to enterovirus
Jackson Clarion Ledger
Children and young adults get the sickest, and it triggers attacks for people with asthma. Enterovirus symptoms are similar to a cold: fever, runny nose, sneezing, cough and body aches. Severe symptoms for asthma sufferers may include coughing
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How dangerous is this new respiratory enterovirus?Boston Globe
Kids with Asthma at Greatest Risk from EV-D68Wawa-news.com
Green Bay Press Gazette –Middleboro Gazette –Casper Journal
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Asthma’s treatment pipeline very strong as more personalized medicines emerge – The Pharma Letter

Asthma's treatment pipeline very strong as more personalized medicines emerge
The Pharma Letter
According to research and consulting firm GlobalData's latest report, the most significant challenge in asthma therapeutics is posed by patients with severe forms of the disease, who remain uncontrolled and have frequent exacerbations, even with the …

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COPD And Asthma Treatment Involves More Than Just Medication; Combination … – Medical Daily


Medical Daily

COPD And Asthma Treatment Involves More Than Just Medication; Combination
Medical Daily
COPD afflicts a patient's lungs, most often in the form of the flu, asthma, chronic bronchitis, emphysema, and lung cancer. Secondhand causes include air pollution, secondhand smoke, occupational dust and chemicals, heredity, and a childhood of
Combination therapy for COPD associated with better outcomesMedical Xpress
Drug Combination Better than LABAs Alone for COPDHealthline
Combo Therapy Best for COPD: StudyHealthDay
2 Minute Medicine
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The orl rat is more responsive to methacholine challenge than wild type.

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The orl rat is more responsive to methacholine challenge than wild type.

Pulm Pharmacol Ther. 2014 Sep 10;

Authors: Rodriguez E, Barthold JS, Kreiger PA, Armani MH, Wang J, Michelini KA, Wolfson MR, Boyce R, Barone CA, Zhu Y, Waldman SA, Shaffer TH

Abstract
BACKGROUND: This study presents an animal model of native airway hyperresponsiveness (AHR). AHR is a fundamental aspect of asthma and reflects an abnormal response characterized by airway narrowing following exposure to a wide variety of non-immunological stimuli. Undescended testis (UDT) is one of the most common male congenital anomalies. The orl rat is a Long Evans substrain with inherited UDT. Since boys born with congenital UDT are more likely to manifest asthma symptoms, the main aim in this study was to investigate the alternative hypothesis that orl rats have greater AHR to a methacholine aerosol challenge than wild type rats.
METHODS: Long Evans wild type (n=9) and orl (n=13) rats were anesthetized, tracheostomized, and mechanically ventilated at 4 weeks of age. Escalating concentrations of inhaled methacholine were delivered. The methacholine potency and efficacy in the strains were measured. Respiratory resistance was the primary endpoint. After the final methacholine aerosol challenge, the short-acting ?2-adrenoceptor agonist albuterol was administered as an aerosol and lung/diaphragm tissues were assayed for interleukin (IL)-4, IL-6, and tumor necrosis factor (TNF)-?. Histological and histomorphometrical analyses were performed.
RESULTS: The methacholine concentration-response curve in the orl group indicated increased sensitivity, hyperreactivity, and exaggerated maximal response in comparison with the wild type group, indicating that orl rats had abnormally greater AHR responses to methacholine. Histological findings in orl rats showed the presence of eosinophils, unlike wild type rats. ?2-adrenoceptor agonist intervention resulted in up-regulation of IL-4 diaphragmatic levels and down-regulation of IL-4 and IL-6 in the lungs of orl rats.
CONCLUSION: orl rats had greater AHR than wild type rats during methacholine challenge, with higher IL-4 levels in diaphragmatic tissue homogenates. Positive immunostaining for IL-4 was detected in lung and diaphragmatic tissue in both strains. This model offers advantages over other pre-clinical murine models for studying potential mechanistic links between cryptorchidism and asthma. This animal model may be useful for further testing of compounds/therapeutics options for treating AHR.

PMID: 25218882 [PubMed – as supplied by publisher]

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Overweight Children Are More Likely to Develop Asthma – University Herald


University Herald

Overweight Children Are More Likely to Develop Asthma
University Herald
Although the link between childhood obesity and asthma has been known for years, researchers have not been able to determine which conditions tends to come first, or whether one causes the other. Researchers found that it is more probable that
For kids with both asthma and obesity, which came first?EurekAlert (press release)
First report of allergic reaction to antibiotic pesticides consumed in foodMedical News Today
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Targeting asthma, food allergies and more, Allakos bumps up Series A to $42M – San Francisco Business Times (blog)

Targeting asthma, food allergies and more, Allakos bumps up Series A to $42M
San Francisco Business Times (blog)
The San Mateo company, founded by veterans of KaloBios Pharmaceuticals Inc., is developing antibody-based drugs against inflammatory diseases, such as asthma, food allergies and gastrointestinal conditions. It is zeroing in on so-called T-helper cells, …

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