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Early life dysbiosis increases asthma risk
Nature.com Mouse models have pointed to a role for dysbiosis of the gut microbiota during early life in the aetiology of asthma. Arrieta et al. surveyed 319 children from a 3-year longitudinal study and found that a similar phenomenon occurs in humans. 16S rRNA … |
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Nociceptors in asthma
Nature.com Asthma is a heterogenous inflammatory disease characterized by massive infiltration of neutrophils or eosinophils into the lungs after exposure to allergens or other noxious agents. In Neuron, Talbot et al. reveal a role for lung nociceptor neurons in … |
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Nuclear Bioavailability of the Glucocorticoid Receptor in a Pediatric Asthma …
Nature.com Despite the overall effectiveness of glucocorticoids (GCs) in the treatment of asthma, a large proportion of patients do not fully respond to this medication. The objective of the present study was to investigate the potential molecular mechanisms … |
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An IFN? bias in severe asthma
Nature.com Asthma is a phenotypically heterogeneous disease with ~10% of individuals having a severe form that is poorly controlled by corticosteroids. Recent evidence suggests that the type of immune response associated with severe asthma is distinct from the … |
View full post on asthma – Google News
Nature.com |
An IFN? bias in severe asthma – Nature
Nature.com Asthma is a phenotypically heterogeneous disease with ~10% of individuals having a severe form that is poorly controlled by corticosteroids. Recent evidence suggests that the type of immune response associated with severe asthma is distinct from the … |
View full post on asthma – Google News
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Target neurons to relieve asthma
Nature.com Silencing signals from pain-sensing nerve cells in the lungs reduces the symptoms of asthma in mice. When stimulated by allergens, these neurons cause airways to constrict and trigger symptoms such as coughing and wheezing. Bruce Levy and Clifford … |
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Excess free fructose and childhood asthma
Nature.com I read the article that appeared in your March 2015 issue titled, 'Associations of sugar-containing beverages with asthma prevalence in 11-year-old children: the PIAMA birth cohort' with great interest. Further insights could be gained if Berentzen et … |
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Bronchial lesions of mouse model of asthma are preceded by immune complex …
Nature.com We systematically examined by immune histology the lungs of some widely used mouse models of asthma. These models include sensitization by multiple intraperitoneal injections of soluble ovalbumin (OVA) or of OVA with alum, followed by three intranasal … |
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Risk of idiopathic nephrotic syndrome among children with asthma: a nationwide …
Nature.com Although clinical and immunological studies have shown a possible link between allergy and idiopathic nephrotic syndrome (INS), the nature of the relationship remains unclear. Asthma is the most common chronic allergic airway inflammation. However, no … |
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Type 2 inflammation in asthma — present in most, absent in many
Nature.com In the version of this article that was originally published, the targeted epitope of lebrikizumab was listed as "IL?4R?" in Table 1 but this should be "IL?13 (IL?4Rz??binding epitope)". Also, for the main effects of lebrikizumab in human asthma trials … |
View full post on asthma – Google News