Humoral immune factors and asthma among American Indian children: a case–control study – BMC Blogs Network

Humoral immune factors and asthma among American Indian children: a case–control study
BMC Blogs Network
Asthma is recognized as intimately related to immunologic factors and inflammation, although there are likely multiple phenotypes and pathophysiologic pathways. Biomarkers of inflammation may shed light on causal factors and have potential clinical

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Allergy & Asthma Network to Advocate for Patients, Access to Care Innovations at Annual Capitol Hill Day on May 12 – PR Newswire (press release)

Allergy & Asthma Network to Advocate for Patients, Access to Care Innovations at Annual Capitol Hill Day on May 12
PR Newswire (press release)
VIENNA, Va., April 25, 2016 /PRNewswire-USNewswire/ — Allergy & Asthma Network will head to Capitol Hill on Thursday, May 12 to advocate for patients and urge Congress to take action on key legislative issues including telehealth services and school …
AAFA's asthma & allergy friendly(TM) Certification Program Celebrates 10 Successful YearsMarketwired (press release)

all 2 news articles »

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Doctor On Demand, Allergy & Asthma Network Team Up To Make Treating Asthma and Allergies Easier for Millions – PR Newswire (press release)


KMBC Kansas City

Doctor On Demand, Allergy & Asthma Network Team Up To Make Treating Asthma and Allergies Easier for Millions
PR Newswire (press release)
SAN FRANCISCO, April 20, 2016 /PRNewswire-USNewswire/ — Today Doctor On Demand, the leading U.S. video medicine provider, announced a new partnership with Allergy & Asthma Network to improve allergy and asthma care for its members. Doctor …
Northwestern Medicine develops new technology to treat allergies, asthmaDaily Northwestern
Spring Asthma & Allergy TipsKMBC Kansas City
5 tips to breathe easy this springQuad-Cities Online
CNN –Royal Gazette
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Differential gene network analysis for the identification of asthma-associated therapeutic targets in allergen-specific T-helper memory responses.

Differential gene network analysis for the identification of asthma-associated therapeutic targets in allergen-specific T-helper memory responses.

BMC Med Genomics. 2016;9(1):9

Authors: Troy NM, Hollams EM, Holt PG, Bosco A

Abstract
BACKGROUND: Asthma is strongly associated with allergic sensitization, but the mechanisms that determine why only a subset of atopics develop asthma are not well understood. The aim of this study was to test the hypothesis that variations in allergen-driven CD4 T cell responses are associated with susceptibility to expression of asthma symptoms.
METHODS: The study population consisted of house dust mite (HDM) sensitized atopics with current asthma (n?=?22), HDM-sensitized atopics without current asthma (n?=?26), and HDM-nonsensitized controls (n?=?24). Peripheral blood mononuclear cells from these groups were cultured in the presence or absence of HDM extract for 24 h. CD4 T cells were then isolated by immunomagnetic separation, and gene expression patterns were profiled on microarrays.
RESULTS: Differential network analysis of HDM-induced CD4 T cell responses in sensitized atopics with or without asthma unveiled a cohort of asthma-associated genes that escaped detection by more conventional data analysis techniques. These asthma-associated genes were enriched for targets of STAT6 signaling, and they were nested within a larger coexpression module comprising 406 genes. Upstream regulator analysis suggested that this module was driven primarily by IL-2, IL-4, and TNF signaling; reconstruction of the wiring diagram of the module revealed a series of hub genes involved in inflammation (IL-1B, NFkB, STAT1, STAT3), apoptosis (BCL2, MYC), and regulatory T cells (IL-2Ra, FoxP3). Finally, we identified several negative regulators of asthmatic CD4 T cell responses to allergens (e.g. IL-10, type I interferons, microRNAs, drugs, metabolites), and these represent logical candidates for therapeutic intervention.
CONCLUSION: Differential network analysis of allergen-induced CD4 T cell responses can unmask covert disease-associated genes and pin point novel therapeutic targets.

PMID: 26922672 [PubMed – as supplied by publisher]

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Striking variations by ethnic group in asthma in Scotland – BMC Blogs Network (blog)


BMC Blogs Network (blog)

Striking variations by ethnic group in asthma in Scotland
BMC Blogs Network (blog)
Asthma causes wheezing and shortness of breath long-term in over 300 million people globally. A systematic review and meta-analysis published in 2005 showed marked ethnic variations in asthma in the UK, with ethnic minority origin individuals being, …

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Effects of Continuity of Care on Emergency Department Utilization in Children … – AJMC.com Managed Markets Network

Effects of Continuity of Care on Emergency Department Utilization in Children
AJMC.com Managed Markets Network
Conclusions: High continuity of ambulatory asthma care can decrease asthma-specific ED utilization risk in children with newly diagnosed asthma in Taiwan. We suggest that providers and the government reinforce the use of follow-up care and education

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