Tag: Nocturnal

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Objective measurement of frequency and pattern of nocturnal cough in children with asthma exacerbation.

Objective measurement of frequency and pattern of nocturnal cough in children with asthma exacerbation.

Ann Allergy Asthma Immunol. 2016 Jun 30;

Authors: Hirai K, Enseki M, Tabata H, Nukaga M, Matsuda S, Kato M, Furuya H, Mochizuki H

Abstract
BACKGROUND: Although a number of patients with asthma report experiencing persistent cough during sleep, it has not yet been objectively investigated.
OBJECTIVE: To classify cough severity and evaluate a characteristic pattern of cough frequency in children with asthma using an objective cough monitoring system.
METHODS: An objective cough monitoring system that specialized in children was used to measure cough frequency and nocturnal cough patterns. Coughs were recorded with microphone and accelerometer and analyzed using a customized software program. The number of nocturnal coughs and the pattern of cough frequency in 30-minute intervals were measured along with the severity of each asthma exacerbation, and the results were compared with children without asthma.
RESULTS: The total overnight cough count of 34 children with asthma was higher than that of 15 children without asthma (P < .001). The total overnight cough count in children with severe asthma exacerbation was higher than that in children with moderate asthma exacerbation (P < .05). The cough counts were significantly increased at the time of falling asleep and waking. This pattern was not observed in children without asthma. The total cough counts and cough patterns in children with asthma were not affected by sex, age, cause of asthma exacerbation, or therapy.
CONCLUSION: Our data indicate huge cough counts and characteristic nocturnal cough patterns in children with asthma. Objective and precise cough monitoring is useful for the management of childhood asthma.

PMID: 27372657 [PubMed – as supplied by publisher]

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Nocturnal gastroesophageal reflux, asthma and symptoms of obstructive sleep apnoea: a longitudinal, general population study.

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Nocturnal gastroesophageal reflux, asthma and symptoms of obstructive sleep apnoea: a longitudinal, general population study.

Eur Respir J. 2012 Sep 27;

Authors: Emilsson OI, Bengtsson A, Franklin KA, Torén K, Benediktsdóttir B, Farkhooy A, Weyler J, Dom S, Backer WD, Gislason T, Janson C

Abstract
Nocturnal gastroesophageal reflux (nGER) is associated with asthma and obstructive sleep apnoea (OSA). Our aim was to investigate whether nGER is a risk factor for onset of asthma and onset of respiratory and OSA symptoms in a prospective population based study.We invited 2640 subjects from Iceland, Sweden and Belgium for two evaluations over a nine years interval. They participated in structured interviews, answered questionnaires, underwent spirometries and methacholine challenge testing. nGER was defined by reported symptoms.Subjects with persistent nGER (n=123) had an independent increased risk of new asthma at follow-up [OR (95% CI): 2.3 (1.1-4.9)]. Persistent nGER was independently related to onset of respiratory symptoms [OR (95% CI): 3.0 (1.6-5.6)]. The risk of developing symptoms of OSA was increased in subjects with new and persistent nGER [OR (95% CI): 2.2 (1.3-1.6) and 2.0 (1.0-3.7), respectively]. No significant association was found between nGER and lung function or bronchial responsiveness.Persistent symptoms of nocturnal gastroesophageal reflux contributes to the development of asthma and respiratory symptoms. New onset of OSA symptoms is higher among subjects with symptoms of nGER. These findings support that nGER may play a role in the genesis of respiratory symptoms and diseases.

PMID: 23018910 [PubMed – as supplied by publisher]

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