Condition: Asthma
Intervention: Device: CareTRx
Sponsor: Children’s Hospital Boston
Not yet recruiting – verified August 2015
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
Condition: Asthma
Intervention: Device: CareTRx
Sponsor: Children’s Hospital Boston
Not yet recruiting – verified August 2015
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
2 Minute Medicine |
Syndecan-4 identified as novel target for asthma treatment [PreClinical]
2 Minute Medicine Study Rundown: Asthma, an immune system disorder characterized by airway inflammation and difficulty breathing, affects about 25 million people in the United States alone. Both long- and short-term medications are available for regulating inflammation … |
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Lung Disease News |
Novel Asthma App Helps Patients Control Disease Symptoms
Lung Disease News The expression “There's an app for that” continues to prove time and again how substantial an impact mobile technology can have on our daily lives — including those who suffer from diseases such as asthma. A recent article published in the Annals of … |
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Related Articles |
Nanotubes Connect CD4+ T Cells to Airway Smooth Muscle Cells: Novel Mechanism of T Cell Survival.
J Immunol. 2015 May 1;
Authors: Al Heialy S, Zeroual M, Farahnak S, McGovern T, Risse PA, Novali M, Lauzon AM, Roman HN, Martin JG
Abstract
Contact between airway smooth muscle (ASM) cells and activated CD4(+) T cells, a key interaction in diseases such as asthma, triggers ASM cell proliferation and enhances T cell survival. We hypothesized that direct contact between ASM and CD4(+) T cells facilitated the transfer of anti-apoptotic proteins via nanotubes, resulting in increased survival of activated CD4(+) T cells. CD4(+) T cells, isolated from PBMCs of healthy subjects, when activated and cocultured with ASM cells for 24 h, formed nanotubes that were visualized by immunofluorescence and atomic force microscopy. Cell-to-cell transfer of the fluorescent dye calcein-AM confirmed cytoplasmic communication via nanotubes. Immunoreactive B cell lymphoma 2 (Bcl-2) and induced myeloid leukemia cell differentiation protein (Mcl-1), two major anti-apoptotic proteins, were present within the nanotubes. Downregulation of Mcl-1 by small interfering RNA in ASM cells significantly increased T cell apoptosis, whereas downregulation of Bcl-2 had no effect. Transfer of GFP-tagged Mcl-1 from ASM cells to CD4(+) T cells via the nanotubes confirmed directionality of transfer. In conclusion, activated T cells communicate with ASM cells via nanotube formation. Direct transfer of Mcl-1 from ASM to CD(+) T cells via nanotubes is involved in T cell survival. This study provides a novel mechanism of survival of CD4(+) T cells that is dependent on interaction with a structural cell.
PMID: 25934863 [PubMed – as supplied by publisher]
View full post on pubmed: asthma
Calcium Sensing Receptor: Asthma's Potential Root Cause And A Novel Treatment
Science 2.0 Researchers have described the role of the calcium sensing receptor (CaSR) in causing asthma, a disease which affects 300 million people worldwide, by using mouse models of asthma and human airway tissue from asthmatic and non-asthmatic people. New asthma therapy? Approved drugs show promise New Study Claims Asthma Could Be Cured In Five Years Possible cause for some cases of asthma discovered |
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International Business Times AU |
Scientists discover asthma's potential root cause and a novel treatment
Science Daily Dr Samantha Walker, Director of Research and Policy at Asthma UK, who helped fund the research, said: "This hugely exciting discovery enables us, for the first time, to tackle the underlying causes of asthma symptoms. Five per cent of people with … Drug Breakthrough: Asthma May Have A Cure Soon Asthma treatment breakthrough incredibly exciting: Scientists Asthma Cure May Be Possible |
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Medical Xpress |
Scientists discover asthma's potential root cause and a novel treatment
Medical Xpress "Our paper shows how these triggers release chemicals that activate CaSR in airway tissue and drive asthma symptoms like airway twitchiness, inflammation, and narrowing. Using calcilytics, nebulized directly into the lungs, we show that it is possible … Asthma could be cured within five years after drug breakthrough Asthma breakthrough as scientists discover root cause and treatment 5 years away Probable asthma cause and 'cheap' treatment discovered |
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Laboratory Equipment |
Novel approach to treating asthma
R & D Magazine Current asthma treatments can alleviate wheezing, coughing and other symptoms felt by millions of Americans every year, but they don't get to the root cause of the condition. Now, for the first time, scientists are reporting a new approach to defeating … Neutralizing Trigger Can Fight Asthma |
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Novel approach to treating asthma: Neutralize the trigger
EurekAlert (press release) Current asthma treatments can alleviate wheezing, coughing and other symptoms felt by millions of Americans every year, but they don't get to the root cause of the condition. Now, for the first time, scientists are reporting a new approach to defeating … |
View full post on asthma – Google News
HCPLive |
Researchers Pinpoint Novel Asthma Treatment Target
HCPLive Existing medication containing inhaled steroids, are highly effective at controlling regular asthma symptoms, but during an attack the symptoms worsen and can lead to the patient going to hospital,” commented Sebastian Johnston of the National Heart … |
View full post on asthma – Google News