Syndecan-4 identified as novel target for asthma treatment [PreClinical] – 2 Minute Medicine


2 Minute Medicine

Syndecan-4 identified as novel target for asthma treatment [PreClinical]
2 Minute Medicine
Study Rundown: Asthma, an immune system disorder characterized by airway inflammation and difficulty breathing, affects about 25 million people in the United States alone. Both long- and short-term medications are available for regulating inflammation

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Nanotubes Connect CD4+ T Cells to Airway Smooth Muscle Cells: Novel Mechanism of T Cell Survival.

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Nanotubes Connect CD4+ T Cells to Airway Smooth Muscle Cells: Novel Mechanism of T Cell Survival.

J Immunol. 2015 May 1;

Authors: Al Heialy S, Zeroual M, Farahnak S, McGovern T, Risse PA, Novali M, Lauzon AM, Roman HN, Martin JG

Abstract
Contact between airway smooth muscle (ASM) cells and activated CD4(+) T cells, a key interaction in diseases such as asthma, triggers ASM cell proliferation and enhances T cell survival. We hypothesized that direct contact between ASM and CD4(+) T cells facilitated the transfer of anti-apoptotic proteins via nanotubes, resulting in increased survival of activated CD4(+) T cells. CD4(+) T cells, isolated from PBMCs of healthy subjects, when activated and cocultured with ASM cells for 24 h, formed nanotubes that were visualized by immunofluorescence and atomic force microscopy. Cell-to-cell transfer of the fluorescent dye calcein-AM confirmed cytoplasmic communication via nanotubes. Immunoreactive B cell lymphoma 2 (Bcl-2) and induced myeloid leukemia cell differentiation protein (Mcl-1), two major anti-apoptotic proteins, were present within the nanotubes. Downregulation of Mcl-1 by small interfering RNA in ASM cells significantly increased T cell apoptosis, whereas downregulation of Bcl-2 had no effect. Transfer of GFP-tagged Mcl-1 from ASM cells to CD4(+) T cells via the nanotubes confirmed directionality of transfer. In conclusion, activated T cells communicate with ASM cells via nanotube formation. Direct transfer of Mcl-1 from ASM to CD(+) T cells via nanotubes is involved in T cell survival. This study provides a novel mechanism of survival of CD4(+) T cells that is dependent on interaction with a structural cell.

PMID: 25934863 [PubMed – as supplied by publisher]

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Calcium Sensing Receptor: Asthma’s Potential Root Cause And A Novel Treatment – Science 2.0

Calcium Sensing Receptor: Asthma's Potential Root Cause And A Novel Treatment
Science 2.0
Researchers have described the role of the calcium sensing receptor (CaSR) in causing asthma, a disease which affects 300 million people worldwide, by using mouse models of asthma and human airway tissue from asthmatic and non-asthmatic people.
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Scientists discover asthma’s potential root cause and a novel treatment – Science Daily


International Business Times AU

Scientists discover asthma's potential root cause and a novel treatment
Science Daily
Dr Samantha Walker, Director of Research and Policy at Asthma UK, who helped fund the research, said: "This hugely exciting discovery enables us, for the first time, to tackle the underlying causes of asthma symptoms. Five per cent of people with
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Scientists discover asthma’s potential root cause and a novel treatment – Medical Xpress


Medical Xpress

Scientists discover asthma's potential root cause and a novel treatment
Medical Xpress
"Our paper shows how these triggers release chemicals that activate CaSR in airway tissue and drive asthma symptoms like airway twitchiness, inflammation, and narrowing. Using calcilytics, nebulized directly into the lungs, we show that it is possible
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Novel approach to treating asthma – R & D Magazine


Laboratory Equipment

Novel approach to treating asthma
R & D Magazine
Current asthma treatments can alleviate wheezing, coughing and other symptoms felt by millions of Americans every year, but they don't get to the root cause of the condition. Now, for the first time, scientists are reporting a new approach to defeating
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Novel approach to treating asthma: Neutralize the trigger – EurekAlert (press release)

Novel approach to treating asthma: Neutralize the trigger
EurekAlert (press release)
Current asthma treatments can alleviate wheezing, coughing and other symptoms felt by millions of Americans every year, but they don't get to the root cause of the condition. Now, for the first time, scientists are reporting a new approach to defeating

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