Breathe Well Live Well
Condition: Premature Birth- and BPD-related Obstructive Lung Disease
Intervention:
Sponsors: Karolinska Institutet; Swedish Heart Lung Foundation; The Swedish Research Council; Stockholm County Council, Sweden; Stockholm South General Hospital; University of California, San Francisco; Kyoto University; Göteborg University; University of Oulu
Recruiting – verified October 2016
View full post on ClinicalTrials.gov: asthma | Studies received in the last 14 days
Conditions: Pulmonary Arteriovenous Malformations; Hereditary Hemorrhagic Telangiectasia; Asthma; COPD
Intervention: Other: Cardiopulmonary exercise test
Sponsor: Imperial College London
Not yet recruiting – verified April 2015
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
Lung Disease News |
New Study on Fixed Airways Obstruction Among Patients With Severe Asthma …
Lung Disease News Asthma is a chronic inflammatory disease of the airways and is characterized by reversible airflow obstruction in response to bronchodilators or inhaled corticosteroids. The most severe cases, accounting for 5% of all asthma cases, are associated with … |
View full post on asthma – Google News
Increased apoptosis of CD4 and CD8 T lymphocytes in the airways of horses with recurrent airway obstruction.
Vet Res Commun. 2011 May 19;
Authors: Moran G, Buechner-Maxwell VA, Folch H, Henriquez C, Galecio JS, Perez B, Carrasco C, Barria M
Recurrent airway obstruction (RAO, also known as equine heaves) is an inflammatory condition similar to human asthma caused by exposure of susceptible horses to poorly ventilated stable environments. The disease is characterized by neutrophilic airway inflammation, mucus hypersecretion and reversible bronchoconstriction. This inflammatory process is mediated by several factors, including antibodies, cytokines, resident cells of the airway and inflammatory cellular components that arrive in the respiratory tract. An increasing body of evidence has lent support to the concept that a dysregulation of T cell apoptosis may play a central role in the development of airway inflammation and the associated asthma. Therefore, the aim of this study was to investigate early and late apoptosis of CD4 and CD8 T cell subpopulations obtained from the airways of acute RAO-positive animals after exposure to hay/straw. The percentages of CD4 and CD8 T cells and their associated frequencies of apoptosis were quantified using flow cytometry. Hay/straw exposure induced clinical airway obstruction, airway neutrophilia and increased airway mucus production in RAO-positive horses. In addition, allergen exposure increased the percentage of CD4 T cells in RAO-positive horses as well as the frequency of early and late apoptosis in both CD4 and CD8 lymphocyte subpopulations. These results suggest that the higher frequency of lymphocyte apoptosis may play a role in disease progression of horses afflicted with RAO and may partially explain the characteristic remission of this pathological condition once the allergen source is removed. However, further studies are needed to clarify the role of T cell apoptosis in RAO-affected horses.
PMID: 21594641 [PubMed – as supplied by publisher]
View full post on pubmed: asthma
Grading the Severity of Obstruction in Mixed Obstructive-Restrictive Lung Disease.
Chest. 2011 Mar 17;
Authors: Gardner ZS, Ruppel GL, Kaminsky DA
ABSTRACT BACKGROUND: The severity of obstructive pulmonary disease is determined by the percent predicted FEV(1) based on ATS/ERS guidelines. In patients with coexisting restrictive lung disease, the decrease in FEV(1) can overestimate the degree of obstruction. We hypothesize that adjusting the FEV(1) for the decrease in TLC results in a more appropriate grading of the severity of obstruction. METHODS: We examined a large PFT database and identified patients with both restrictive (TLC < 80% predicted) and obstructive (FEV(1)/FVC < the lower limit of normal) lung disease. FEV(1) percent predicted was adjusted for the degree of restriction by dividing it by percent predicted TLC. We compared the distribution of severity grading between adjusted and unadjusted values according to ATS/ERS criteria, and determined how the distribution of severity would change based on asthma and COPD guidelines. RESULTS: We identified 199 patients with coexisting restrictive and obstructive lung disease. By ATS/ERS grading, the unadjusted data categorized 76% of patients as having severe or very severe obstruction, and 11% as having mild or moderate obstruction. The adjusted data classified 33% with severe or very severe obstruction, and 44% with mild or moderate obstruction. Of the corrected values, 83% resulted in a change to less severe obstruction by ATS/ERS guidelines, and 44% and 70% of patients, respectively, would be reclassified as having less severe obstruction by current asthma and COPD guidelines. CONCLUSIONS: This method results in a more appropriate distribution of severity of obstruction, which should lead to more accurate treatment of obstruction in these patients.
PMID: 21415132 [PubMed – as supplied by publisher]
View full post on pubmed: asthma