FDA Panel Recommends Asthma Treatment Approval for Adults Only – Pharmacy Times (registration)


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FDA Panel Recommends Asthma Treatment Approval for Adults Only
Pharmacy Times (registration)
"We recognize the advisory committee's thoroughness in reviewing the data related to Breo Ellipta for asthma,” said Darrell Baker, senior vice president and head of GSK's Global Respiratory Franchise, in a press release. “We will continue to work
GSK And Theravance: Implications Of The Advisory Panel DecisionSeeking Alpha (registration)
Breo Ellipta receives Mixed Views from FDA PanelUncover California

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GSK’s Breo for asthma? FDA panel says yes–but only in adults – FiercePharma

GSK's Breo for asthma? FDA panel says yes–but only in adults
FiercePharma
Good news for GlaxoSmithKline ($GSK): An FDA panel of experts says the efficacy and safety data for blockbuster wannabe Breo support the asthma indication it's gunning for in adults 18 and older. When it comes to children aged 12 to 17, though?
UPDATE 2-FDA panel backs Glaxo asthma drug for adults, not adolescentsReuters
U.S. Panel Backs Glaxo's Breo for Asthma in Adults, Not KidsBloomberg
FDA panel backs Glaxo asthma drug for adults, not adolescentsBusiness Insider
RTT News
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Asthma: Think it can only start in childhood? Wrong – and in later life it can … – Daily Mail


Daily Mail

Asthma: Think it can only start in childhood? Wrong – and in later life it can
Daily Mail
Aspirin and other NSAIDs inhibit the action of an enzyme called COX?1, increasing the production of chemicals called leukotrienes, which cause inflammation and can produce the symptoms of asthma and allergy-like effects, says Dr Menzies-Gow.

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Are only 7% of asthma sufferers using inhalers the right way? – MedCity News


International Business Times AU

Are only 7% of asthma sufferers using inhalers the right way?
MedCity News
The charity Asthma UK is making an effort to increase care for patients who aren't using their inhalers the correct way, which leads to use of stronger inhalers that aren't actually necessary. This insight comes after a separate U.S. study found that
Experts Evaluate Use of Allergy And Asthma DevicesInternational Business Times AU

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Only 7 percent asthma patients know how to use inhalers properly – America Herald


America Herald

Only 7 percent asthma patients know how to use inhalers properly
America Herald
A new study has shown that very few people know the proper usage of the medical devices containing lifesaving medications for asthma attacks and severe allergies. According to the researchers, only seven percent of the asthma patients know the correct …

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Lung-Homing of Endothelial Progenitor Cells and Airway Vascularization Is Only Partially Dependant on Eosinophils in a House Dust Mite-Exposed Mouse Model of Allergic Asthma.

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Lung-Homing of Endothelial Progenitor Cells and Airway Vascularization Is Only Partially Dependant on Eosinophils in a House Dust Mite-Exposed Mouse Model of Allergic Asthma.

PLoS One. 2014;9(10):e109991

Authors: Sivapalan N, Wattie J, Inman MD, Sehmi R

Abstract
BACKGROUND: Asthmatic responses involve a systemic component where activation of the bone marrow leads to mobilization and lung-homing of progenitor cells. This traffic may be driven by stromal cell derived factor-1 (SDF-1), a potent progenitor chemoattractant. We have previously shown that airway angiogenesis, an early remodeling event, can be inhibited by preventing the migration of endothelial progenitor cells (EPC) to the lungs. Given intranasally, AMD3100, a CXCR4 antagonist that inhibits SDF-1 mediated effects, attenuated allergen-induced lung-homing of EPC, vascularization of pulmonary tissue, airway eosinophilia and development of airway hyperresponsiveness. Since SDF-1 is also an eosinophil chemoattractant, we investigated, using a transgenic eosinophil deficient mouse strain (PHIL) whether EPC lung accumulation and lung vascularization in allergic airway responses is dependent on eosinophilic inflammation.
METHODS: Wild-type (WT) BALB/c and eosinophil deficient (PHIL) mice were sensitized to house dust mite (HDM) using a chronic exposure protocol and treated with AMD3100 to modulate SDF-1 stimulated progenitor traffic. Following HDM challenge, lung-extracted EPCs were enumerated along with airway inflammation, microvessel density (MVD) and airway methacholine responsiveness (AHR).
RESULTS: Following Ag sensitization, both WT and PHIL mice exhibited HDM-induced increase in airway inflammation, EPC lung-accumulation, lung angiogenesis and AHR. Treatment with AMD3100 significantly attenuated outcome measures in both groups of mice. Significantly lower levels of EPC and a trend for lower vascularization were detected in PHIL versus WT mice.
CONCLUSIONS: This study shows that while allergen-induced lung-homing of endothelial progenitor cells, increased tissue vascularization and development lung dysfunction can occur in the absence of eosinophils, the presence of these cells worsens the pathology of the allergic response.

PMID: 25279605 [PubMed – as supplied by publisher]

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Does ?-Hexosaminidase Function Only as a Degranulation Indicator in Mast Cells? The Primary Role of ?-Hexosaminidase in Mast Cell Granules.

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Does ?-Hexosaminidase Function Only as a Degranulation Indicator in Mast Cells? The Primary Role of ?-Hexosaminidase in Mast Cell Granules.

J Immunol. 2014 Jul 11;

Authors: Fukuishi N, Murakami S, Ohno A, Yamanaka N, Matsui N, Fukutsuji K, Yamada S, Itoh K, Akagi M

Abstract
?-Hexosaminidase, which is generally present in the lysosome, is essential for glycoprotein metabolism in the maintenance of cell homeostasis. In mast cells (MCs), large amounts of ?-hexosaminidase are present in the granules as opposed to the lysosome, and the biological role of MC ?-hexosaminidase has yet to be fully elucidated. Therefore, we investigated the biological role of ?-hexosaminidase in MC granules. Bone marrow-derived MCs from C57BL/6 (BL/6-BMMC) or ?-hexosaminidase gene-deficient (hexb(-/-)-BMMC) mice were transplanted into MC-deficient (WBB6F1/J-Kit(W)/Kit(W-v) [W/W(v)]) mice to generate MC-reconstituted models. In asthma model experiments, no differences were observed in the symptoms of BL/6, W/W(v), BL/6-BMMC-reconstituted W/W(v), or hexb(-/-)-BMMC-reconstituted W/W(v) mice. In Staphylococcus epidermidis experimental infection model experiments, the severity of symptoms and frequency of death were markedly higher in W/W(v) and hexb(-/-)-BMMC-reconstituted W/W(v) mice than in BL/6 and BL/6-BMMC-reconstituted W/W(v) mice. The growth of S. epidermidis in an in vitro study was clearly inhibited by addition of BL/6-BMMC lysate, but not by addition of hexb(-/-)-BMMC lysate. Moreover, suppression of bacterial proliferation was completely recovered when bacteria were incubated with hexb(-/-)-BMMC lysate plus ?-hexosaminidase. Transmission electron microscopy indicated that the cell wall of S. epidermidis was heavily degraded following coincubation of bacteria with BL/6-BMMC lysate, but not following coincubation with hexb(-/-)-BMMC lysate. These findings strongly suggest that MC granule ?-hexosaminidase is crucial for defense against bacterial invasion, but is not involved in the allergic response. Our results also suggest that the bactericidal mechanism of ?-hexosaminidase involves degradation of bacterial cell wall peptidoglycan.

PMID: 25015817 [PubMed – as supplied by publisher]

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Mobile clinics provide only asthma treatment for some Detroit children – The Detroit News

Mobile clinics provide only asthma treatment for some Detroit children
The Detroit News
Between 18-20 percent of Detroit Public School children have asthma, according to Ora Beard, principal of Dixon Educational Learning Academy in Detroit. Often left untreated because families don't have access to health care and schools don't have

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