Breathe Well Live Well
|
Study: Racism Linked To Adult Onset Asthma In Black Women
News One A study released by Boston University researchers have linked the experience of racism to cases of adult-onset asthma in African-American women. The study, released by the school's Slone Epidemiology Center (SEC), says Black women who experienced … |
View full post on asthma – Google News
Onset of Bronchodilation with Fluticasone/Formoterol Combination Versus Fluticasone/Salmeterol in an Open-Label, Randomized Study.
Adv Ther. 2012 Oct 17;
Authors: Aalbers R, Brusselle G, McIver T, Grothe B, Bodzenta-Lukaszyk A
Abstract
INTRODUCTION: The inhaled corticosteroid, fluticasone propionate (fluticasone), and the long-acting beta(2)-agonist, formoterol fumarate (formoterol), have been combined in a single aerosol inhaler (fluticasone/formoterol). In a randomized, open-label study, fluticasone/formoterol showed similar efficacy to fluticasone/salmeterol after 12 weeks of treatment. This post-hoc analysis compared the onset of bronchodilation with the two treatments. METHODS: Adults with mild-to-moderate-severe persistent asthma were randomized to fluticasone/formoterol (100/10 or 250/10 ?g twice daily [b.i.d.]) or fluticasone/salmeterol (100/50 or 250/50 ?g b.i.d.) for 12 weeks. The onset of bronchodilation (the first post-dose time point at which the forced expiratory volume in 1 second [FEV(1)] was ?12% greater than the pre-dose value), responder rates (the proportion of patients achieving bronchodilation), and changes in FEV(1) were assessed at days 0 (baseline) and 84. RESULTS: Fluticasone/formoterol (n = 101) provided more rapid onset of bronchodilation than fluticasone/salmeterol (n = 101) over the first 120 min post-dose on days 0 (hazard ratio [HR] = 1.47 [95% CI 1.05-2.05]) and 84 (HR = 1.77 [95% CI 1.14-2.73]). The odds of a patient achieving bronchodilation within 5 min of dosing were almost four-times higher with fluticasone/formoterol than with fluticasone/salmeterol on day 0 (odds ratio [OR] = 3.97 [95% CI 1.96-8.03]) and almost 10-times higher on day 84 (OR = 9.58 [95% CI 2.14-42.90]); the odds of achieving bronchodilation within 120 min post-dose were approximately twofold higher with fluticasone/formoterol on both days. The overall percentage increase in least-squares (LS) mean FEV1 during the 120-min post-dose period was significantly greater with fluticasone/formoterol than fluticasone/salmeterol on days 0 (LS mean treatment difference: 4.70% [95% CI 1.57-7.83]; P = 0.003) and 84 (2.79% [95% CI 0.65-4.93]; P = 0.011). CONCLUSION: These analyses showed that fluticasone/formoterol provided a faster onset of bronchodilation than fluticasone/salmeterol, which was maintained over 12 weeks of treatment. This benefit may facilitate treatment adherence among patients with asthma.
PMID: 23081745 [PubMed – as supplied by publisher]
View full post on pubmed: asthma
| Related Articles |
Epithelial eotaxin-2 and eotaxin-3 expression: relation to asthma severity, luminal eosinophilia and age at onset.
Thorax. 2012 Sep 26;
Authors: Coleman JM, Naik C, Holguin F, Ray A, Ray P, Trudeau JB, Wenzel SE
Abstract
BACKGROUND: Eosinophilic inflammation is implicated in asthma. Eotaxin 1-3 regulate eosinophil trafficking into the airways along with other chemotactic factors. However, the epithelial and bronchoalveolar lavage (BAL) cell expression of these chemokines in relation to asthma severity and eosinophilic phenotypes has not been addressed. OBJECTIVE: To measure the expression of the three eotaxin isoforms in bronchoscopically obtained samples and compare them with clinically relevant parameters between normal subjects and patients with asthma. METHODS: Normal subjects and patients with asthma of varying severity recruited through the Severe Asthma Research Program underwent clinical assessment and bronchoscopy with airway brushing and BAL. Eotaxin 1-3 mRNA/protein were measured in epithelial and BAL cells and compared with asthma severity, control and eosinophilic inflammation. RESULTS: Eotaxin-2 and eotaxin-3 mRNA and eotaxin-2 protein were increased in airway epithelial brushings from patients with asthma and were highest in cases of severe asthma (p values 0.0155, 0.0033 and 0.0006, respectively), with eotaxin-2 protein increased with age at onset. BAL cells normally expressed high levels of eotaxin-2 mRNA/protein but BAL fluid levels of eotaxin-2 were lowest in severe asthma. Epithelial eotaxin-2 and eotaxin-3 mRNA/protein was associated with sputum eosinophilia, lower forced expiratory volume in 1 s and more asthma exacerbations. Airway epithelial cell eotaxin-2 protein differed by asthma severity only in those with late onset disease, and tended to be highest in those with late onset eosinophilic asthma. CONCLUSIONS: Epithelial eotaxin-2 and 3 are increased in asthma and severe asthma. Their expression may contribute to luminal migration of eosinophils, especially in later onset disease, asthma control and severity.
PMID: 23015684 [PubMed – as supplied by publisher]
View full post on pubmed: asthma
 WA today |
Adult onset asthma gets a puff of new wind
WA today Study looks into why some children develop asthma and others develop it once they reach adulthood. A 23-year study into asthma hopes to finally uncover some of the answers about why the chronic disease plagues some children into adulthood while in … |
View full post on asthma – Google News
 Nassau Guardian |
Adult onset asthma has become a lot more commonplace than it was decades ago
Nassau Guardian More adults are developing asthma later in life due to the industrial age and because people are working around a lot more irritants than older generations had. Asthma is a worldwide health concern that affects millions of people regardless of their … |
View full post on asthma – Google News
|
Vitamin A Deficiency Does Not Affect Onset Of Asthma
RedOrbit Vitamin A deficiency does not increase the risk of asthma, according to new research published online in the European Respiratory Journal. In developing countries, vitamin A deficiency is particularly common and previous research has shown that it … |
View full post on asthma – Google News
|
Vitamin A Deficiency Does Not Affect Onset Of Asthma
Medical News Today (press release) Vitamin A deficiency does not increase the risk of asthma, according to new research published online in the European Respiratory Journal. In developing countries, vitamin A deficiency is particularly common and previous research has shown that it … |
View full post on asthma – Google News
|
Greater severity of new onset asthma in allergic subjects who smoke: a 10-year …
7thSpace Interactive (press release) Little is known about the association between cigarette smoking and asthma severity. We assessed smoking as a determinant of disease severity and control in … |
View full post on asthma – Google News
|
Onset Of Asthma Attack Higher Doses Of Inhaled Corticosteroids Has No Effect
allvoices There are two systems in the lungs of persons with asthma. The first one is referred to as is broncho-constriction, which is when the airways narrow during … Asthma exacerbation and large doses of inhaled corticosteroids Inhaled steroids will not help asthma flare ups |
View full post on asthma – Google News
 TheMedGuru |
Genomewide Study Finds Asthma-Associated Genes, One Specific to Childhood Onset
Medscape September 23, 2010 — A genomewide association study has identified several variants associated with asthma throughout the life cycle but found only a … Genetic clue to asthma triggers Asthma comes first, not allergy, study finds Asthma yields up some of its secrets to gene researchers |
View full post on asthma – Google News