Tag: Organic

Posted on

Volatile organic compounds in asthma diagnosis: a systematic review and meta-analysis.

Related Articles

Volatile organic compounds in asthma diagnosis: a systematic review and meta-analysis.

Allergy. 2015 Oct 17;

Authors: Cavaleiro Rufo J, Madureira J, Oliveira Fernandes E, Moreira A

Abstract
We aimed to assess the value and classification rate of exhaled volatile organic compounds (VOCs) in asthma diagnosis. A PRISMA oriented systematic search for published studies regarding exhaled VOCs in asthma diagnosis was conducted based on pre-defined criteria. Studies presenting sensitivity and specificity values for the test were included in the meta-analysis. Pooled diagnosis odds ratios (DOR), area under the curve (AUC) and positive and negative likelihood ratios (LR) for exhaled VOC profiles were calculated; and publication bias, threshold effect and heterogeneity were estimated. Eighteen studies were selected for the qualitative analysis and 6 met the criteria for inclusion in the quantitative analysis. Mean (95%CI) pooled DOR, positive and negative LR were 49.3 (15.9 to 153.3), 5.86 (3.07 to 11.21) and 0.16 (0.10 to 0.26), respectively. The AUC value was 0.94. Only 3 of the 18 reviewed studies performed an external validation of the model using a different dataset. The results from the revised studies suggest that exhaled VOCs are promising biomarkers for asthma diagnosis and that several compounds, mainly alkanes, may be significantly associated with asthma inflammation. However, there are still various constraints associated with standardization and externally validated studies are needed to introduce exhaled VOCs profiling in a clinical scenario. This article is protected by copyright. All rights reserved.

PMID: 26476125 [PubMed – as supplied by publisher]

View full post on pubmed: asthma

Posted on

Aggravation of ovalbumin-induced murine asthma by co-exposure to desert-dust and organic chemicals: an animal model study.

Related Articles

Aggravation of ovalbumin-induced murine asthma by co-exposure to desert-dust and organic chemicals: an animal model study.

Environ Health. 2014 Oct 18;13(1):83

Authors: Ren Y, Ichinose T, He M, Arashidani K, Yoshida Y, Yoshida S, Nishikawa M, Takano H, Sun G, Shibamoto T

Abstract
BACKGROUND: The organic chemicals present in Asian sand dust (ASD) might contribute to the aggravation of lung eosinophila. Therefore, the aggravating effects of the Tar fraction from ASD on ovalbumin (OVA)-induced lung eosinophilia were investigated.
METHODS: The Tar fraction was extracted from ASD collected from the atmosphere in Fukuoka, Japan. ASD collected from the Gobi desert was heated at 360[degree sign]C to inactivate toxic organic substances (H-ASD). ICR mice were instilled intratracheally with 12 different test samples prepared with Tar (1 mug and 5 mug), H-ASD, and OVA in a normal saline solution containing 0.02% Tween 80. The lung pathology, cytological profiles in the bronchoalveolar lavage fluid (BALF), inflammatory cytokines/chemokines in BALF and OVA-specific immunoglobulin in serum were investigated.
RESULTS: Several kinds of polycyclic aromatic hydrocarbons (PAHs) were detected in the Tar sample. H-ASD + Tar 5 mug induced slight neutrophilic lung inflammation. In the presence of OVA, Tar 5 mug increased the level of eosinophils slightly and induced trace levels of Th2 cytokines IL-5 and IL-13 in BALF. Also mild to moderate goblet cell proliferation and mild infiltration of eosinophils in the submucosa of airway were observed. These pathological changes caused by H-ASD + OVA were relatively small. However, in the presence of OVA and H-ASD, Tar, at as low a level as 1 mug, induced severe eosinophil infiltration and proliferation of goblet cells in the airways and significantly increased Th2 cytokines IL-5 and IL-13 in BALF. The mixture showed an adjuvant effect on OVA-specific IgG1 production.
CONCLUSIONS: These results indicate that H-ASD with even low levels of Tar exacerbates OVA-induced lung eosinophilia via increases of Th2-mediated cytokines. These results suggest that ASD-bound PAHs might contribute to the aggravation of lung eosinophila.

PMID: 25326908 [PubMed – as supplied by publisher]

View full post on pubmed: asthma

Posted on

Study Says Organic Products Contain Toxic Chemicals; Industry Groups Say Don’t … – BlissTree


BlissTree

Study Says Organic Products Contain Toxic Chemicals; Industry Groups Say Don't …
BlissTree
The study, conducted by the nonprofit Silent Spring Institute, tested soaps, makeup, lotions, laundry detergents, cleaners, sunscreens, air fresheners and other common stuff for a roster of 66 chemicals thought to cause asthma and hormone disruption.
Hormone-Disrupting Chemicals Found in Many Household Products: StudyU.S. News & World Report
Endocrine Disruptors and Asthma-Associated Chemicals in Consumer Products …ProHealth
Toxics Linked to Hormone Disruption and Asthma Found In Consumer Products …MarketWatch (press release)
WebMD
all 64 news articles »

View full post on asthma – Google News

Posted on

Families Now Have Stylish, Original Choices for Safe Organic Bedding

Families Now Have Stylish, Original Choices for Safe Organic Bedding
BURNABY, BRITISH COLUMBIA–(Marketwire – 05/13/10) – ty and lumi organics crafts modern, professionally designed original prints into baby/toddler duvet covers and blankets . And there’s no drab beige in the whole lot! With hip designs such as Snug as a Ladybug and Sleeping Green , parents no longer need to compromise style to get a safer, cleaner sleep environment for their infants . These new …

Read more on Marketwire via Yahoo! Finance