Outcome after Computer-Assisted (Robotic) Nissen Fundoplication in Children Measured as Pre- and Postoperative Acid Reducing and Asthma Medications Use.

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Outcome after Computer-Assisted (Robotic) Nissen Fundoplication in Children Measured as Pre- and Postoperative Acid Reducing and Asthma Medications Use.

Eur J Pediatr Surg. 2014 Oct 26;

Authors: Granéli C, Kockum CC, Arnbjornsson E, Anderberg M

Abstract
Purpose?This study aims to report the clinical outcome of computer-assisted fundoplication (CAF) in children. Methods?As our center changed policy to using computer-assisted surgery only, a prospectively studied cohort of 40 children underwent CAF, during the period from January 2006 through May 2013. The collected data include patient demographics and postoperative complications as well as medication, 24-hour pH measurements and DeMeester scores before and after surgery. Results?In the studied group, the median percentage of the duration of the 24-hour pH?<?4 decreased postoperatively from 11 (range, 5-39) to 1% (range, 0-12) (p?<?0.001); the DeMeester score decreased from 40 (range, 17-137) to 5 (range, 1-42) (p?<?0.001). All 40 patients required antireflux medication before the fundoplication. This number decreased significantly to 8 (20%) after the fundoplication (p?<?0.001). Before the fundoplication, 22 children (55%) were using asthma medication and 12 (30%) after the fundoplication (p?=?0.04). Conclusions?The CAF significantly reduced the acid reflux from the stomach to the esophagus and the use of antireflux as well as asthma medication during the median observation period of 5 years. The evidence of advantages compared with conventional laparoscopic fundoplication remain to be confirmed.

PMID: 25344939 [PubMed – as supplied by publisher]

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Risk factors for a poor outcome among children admitted with clinically severe pneumonia to a university hospital in Rabat, Morocco.

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Risk factors for a poor outcome among children admitted with clinically severe pneumonia to a university hospital in Rabat, Morocco.

Int J Infect Dis. 2014 Oct 8;

Authors: Jroundi I, Mahraoui C, Benmessaoud R, Moraleda C, Tligui H, Seffar M, Kettani SE, Benjelloun BS, Chaacho S, Muñoz-Almagro C, Ruiz J, Alonso PL, Bassat Q

Abstract
OBJECTIVES: Data on prognostic factors among children with severe pneumonia are scarce in middle-income countries. We investigated prognostic factors for an adverse outcome among children admitted to the Hôpital d’Enfants de Rabat, Morocco with World Health Organization-defined clinically severe pneumonia (CSP).
METHODS: Children aged 2-59 months admitted to the hospital and fulfilling the CSP definition were recruited into this 13-month prospective study. A poor prognosis was defined as death, a need for intensive care, or a Respiratory Index of Severity in Children (RISC) score ?3. Multivariate logistic regression was performed to ascertain independent predictive factors for a poor prognosis.
RESULTS: Of the 689 children included in this analysis, 55 (8.0%) required intensive care and 28 died (4.0%). Five hundred and two (72.8%) children were classified as having a good prognosis and 187 (27.2%) as having a poor prognosis. A history of prematurity (odds ratio (OR) 2.50, 95% confidence interval (CI) 1.24-5.04), of fever (OR 2.25, 95% CI 1.32-3.83), living in a house with smokers (OR 1.79, 95% CI 1.18-2.72), impaired consciousness (OR 10.96, 95% CI 2.88-41.73), cyanosis (OR 2.09, 95% CI 1.05-4.15), pallor (OR 2.27, 95% CI 1.34-3.84), having rhonchi on auscultation (OR 2.45, 95% CI 1.58-3.79), and human metapneumovirus infection (OR 2.13, 95% CI 1.13-4.02) were all independent risk factors for an adverse outcome, whereas a history of asthma (OR 0.46, 95% CI 0.25-0.84) was the only independent risk factor for a positive outcome.
CONCLUSIONS: The early identification of factors associated with a poor prognosis could improve management strategies and the likelihood of survival of Moroccan children with severe pneumonia.

PMID: 25305555 [PubMed – as supplied by publisher]

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Allergic asthma remission with three year treatment: study – Outcome Magazine (blog)


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Allergic asthma remission with three year treatment: study
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Help on the Way for Asthma Sufferers: Study – Outcome Magazine


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Development of a core outcome set for clinical trials in childhood asthma: a … – 7thSpace Interactive (press release)

Development of a core outcome set for clinical trials in childhood asthma: a
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Development of a core outcome set for clinical trials in childhood asthma: a survey of clinicians, parents, and young people – up-to-the-minute news and headlines. 7thSpace is a online portal covering topics such as Family, Business, Entertainment

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New outcome measures may reduce disparities in children with asthma – News-Medical.net

New outcome measures may reduce disparities in children with asthma
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Newly proposed asthma outcome measures will help standardize and improve results from the hundreds of millions of dollars the National Institutes of Health (NIH) spends annually to study asthma, according to the Merck Childhood Asthma Network,
Standardized outcome measures proposed for asthma clinical researchScience Codex

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NIH asthma outcome measures aim to maximize research investments, reduce … – EurekAlert (press release)

NIH asthma outcome measures aim to maximize research investments, reduce
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WASHINGTON, DC, March 2, 2012 – Newly proposed asthma outcome measures will help standardize and improve results from the hundreds of millions of dollars the National Institutes of Health (NIH) spends annually to study asthma, according to the Merck

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