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Pittsburgh part of study to research treatments for black asthma patients
Tribune-Review Research that began this month could lead to better asthma treatments for black people, who tend to develop more severe symptoms from the respiratory disease, a University of Pittsburgh researcher said. The yearlong study financed through the National … |
View full post on asthma – Google News
Condition: Asthma
Interventions: Drug: Budesonide and formoterol fumarate dehydrate (BF) SPIROMAX; Drug: SYMBICORT TURBOHALER budesonide and formoterol fumarate
Sponsors: Teva Pharmaceutical Industries; Teva Branded Pharmaceutical Products, R&D Inc.
Not yet recruiting – verified February 2014
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
Conditions: Pulmonary Disease, Chronic Obstructive; Asthma
Interventions: Drug: LAS190792 Dose 1; Drug: LAS190792 Dose 2; Drug: LAS190792 Dose 3; Drug: LAS190792 Dose 4; Drug: LAS190792 Dose 5; Drug: LAS190792 Dose 6; Drug: LAS190792 Dose 1 (Part 2); Drug: LAS190792 Dose 2 (Part 2); Drug: Tiotropium 18 ?g; Drug: Indacaterol 150 ?g; Drug: Placebo
Sponsor: Almirall, S.A.
Recruiting – verified February 2014
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
Daily Mail |
It's unfair asthma patients must pay for prescriptions: Good Health viewpoint …
Daily Mail Feeling like an elephant is sitting on your chest, gasping for breath, struggling to talk – this is what a terrifying asthma attack is like. Most of the 5.4 million people with asthma in Britain can avoid this ordeal, reducing chances of … |
View full post on asthma – Google News
NPR (blog) |
For Some Asthma Patients, Heat Treatment Tames Symptoms
NPR (blog) Rady has had asthma since she was a toddler. She tried to go away for college, but after a bad flare-up first semester she moved back home. She's now 28, but her lungs are like those of a 65–year-old. If something triggers her airways to twitch and … |
View full post on asthma – Google News
Conditions: Asthma; COPD
Intervention:
Sponsor: Elpen Pharmaceutical Co. Inc.
Not yet recruiting – verified January 2014
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
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New Asthma Treatment Used on SoCal Patients Could Prevent Attacks
NBC Southern California A breakthrough in the asthma treatment process being used to treat patients in Southern California may prevent attacks and cut down hospitalizations. The treatment is called Bronchial Thermoplasty, in which the smooth tissues around the airways are heated. |
View full post on asthma – Google News
Conditions: Prednisone Dependent Asthma; Eosinophilic Bronchitis
Interventions: Biological: Omalizumab (Xolair); Drug: Placebo
Sponsors: McMaster University; Parameswaran Nair; Novartis
Not yet recruiting – verified January 2014
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
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USF research may help asthma patients breathe easier
MyFox Tampa Bay There was a time when running drills at practice might not have been possible for John Matthew Roberts. While this Jesuit High School freshman fights for the ball on the court, his mom's watched him fight for air because of asthma. I asked John Matthew … |
View full post on asthma – Google News
| Related Articles |
Elevated Serum IgE against MGL_1304 in Patients with Atopic Dermatitis and Cholinergic Urticaria.
Allergol Int. 2014 Jan 25;
Authors: Hiragun M, Hiragun T, Ishii K, Suzuki H, Tanaka A, Yanase Y, Mihara S, Haruta Y, Kohno N, Hide M
Abstract
Background: MGL_1304 secreted by Malassezia globosa is contained in human sweat and induces histamine release from basophils in patients with atopic dermatitis (AD) at a high positive rate. The aims of this study were to establish the enzyme-linked immunosorbent assay (ELISA) measuring specific immunoglobulins against MGL_1304 and to investigate the levels of these immunoglobulins in sera of patients with various allergic diseases. Methods: Purified MGL_1304 from human sweat (QRX) and recombinant MGL_1304 (rMGL_1304) were prepared for ELISA. To quantify the amount of MGL_1304-specific immunoglobulins, the standard serum was created by pooling sera of 20 patients with AD whose basophils released histamine in response to QRX. A monoclonal antibody which exhibited the highest neutralizing ability against QRX was established as Smith-2, and used as a capture antibody for the assay of QRX-specific IgE. A total of 156 subjects [normal controls (n = 23), AD (n = 63), cholinergic urticaria (CU) (n = 24), bronchial asthma (n = 32), and allergic rhinitis (n = 14)] were enrolled in this study. Results: ELISA methods to quantify the specific IgE, IgG and IgG4 against MGL_1304 in sera were successfully established. Levels of QRX-specific IgE in sera of patients with AD and CU were significantly higher than those of normal controls. Moreover, the levels of QRX-specific IgE and rMGL_1304-specific IgE in patients with AD were significantly correlated with their disease severities. Conclusions: These ELISA methods to quantify the specific immunoglobulins against MGL_1304 are easy and useful means to assess allergy to MGL_1304. MGL_1304 contained in sweat is an important antigen for patients with AD and CU.
PMID: 24457815 [PubMed – as supplied by publisher]
View full post on pubmed: asthma