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Azithromycin shortens symptom duration for pediatric patients with asthma-like …
Healio Stokholm and colleagues evaluated 72 children aged between 1 year and 3 years from the Copenhagen Prospective Studies on Asthma in Childhood 2010 cohort who randomly received either azithromycin or placebo during an asthma-like episode, … |
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Higher risk for developing zoster observed in adult patients with asthma
Healio “Consideration should be given to immunizing adults 50 years or older with asthma or atopic dermatitis as a target group for zoster vaccine.” Kwon and colleagues identified 371 patients with zoster (66% women; 94% white; mean age 66.8 ± 10.7 years) and … |
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Genetic polymorphisms of the TNF-?-308G/A are associated with metabolic syndrome in asthmatic patients from Hebei province, China.
Int J Clin Exp Pathol. 2015;8(10):13739-46
Authors: Yang YH, Liu YQ, Zhang L, Li H, Li XB, Ouyang Q, Zhu GY
Abstract
Asthma is a complex inflammatory disease involving the critical actions of several important cytokines. Epidemiological data show that obesity could increase the risk of asthma, and insulin resistance, or metabolic syndrome are an important risk factor for obesity asthma. Some studies identified that upstream of the transcription start site within the TNF-? gene promoter region-308 polymorphism was associated insulin resistance or metabolic disorders, while this site was closely related to asthma. But no research was performed to evaluate the influence of TNF-?-308G/A polymorphism on metabolic syndrome in asthmatic patients. Here, we recruited 248 asthmatic patients, who were separated into asthma with Mets/asthma without Mets groups and 226 matched healthy controls from Hebei Province to evaluate the influence of TNF-?-308G/A polymorphism on metabolic syndrome in asthmatic patients. Single nucleotide polymorphism of TNF-?-308 locus was genotyped using PCR-RFLP. Some biochemical variables were also determined. Our result showed that the genotypic and allelic frequency of rs1800629 did not show significant difference between asthmatic patients and normal controls. However, the frequency of A allele was signi?cantly higher in asthma group with Mets (22.36%) than in controls (15.71%) (P = 0.02; OR = 0.647; 95% CI = 0.447-0.936). After analyzing the relationship between biochemical features of patients and genotype of TNF-?-308G/A, we found levels of LDL cholesterol, TNF-? and insulin, and HOMA-IR were significantly higher in the asthmatic patients carrying the GA and AA genotypes than in the carriers of GG genotype of rs1800629 (P = 0.029, P = 0.022, P = 0.043, respectively). Thus, our data suggested that TNF-?-308G/A variation was related to metabolic phenotype in asthma patients. Furthermore, we first identified TNF-?-308 A allele was the risk factor for asthmatic patients with Mets in Hebei population, China.
PMID: 26722602 [PubMed – in process]
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Times of India |
Chennai floods: Asthma patients advised to keep off damp walls
Times of India While asthma is an allergic reaction triggered by various allergens like pollen, dust mites and pets, the increased moisture content in the air during monsoon promotes the growth of moulds or fungal spores, which can grow on damp walls and directly … |
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Survey finds one-third of patients with other respiratory conditions may have …
Healio “Asthma under/misdiagnosis and consequent inappropriate pharmacological treatment still affects asthma management. Furthermore they represent important factors contributing to asthma morbidity and mortality, whereas early detection and management … |
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Condition: Mild Asthma
Interventions: Drug: 90 mcg Reference Product; Drug: 180 mcg Reference Product; Drug: 90 mcg Test Product; Drug: Placebo
Sponsor: Cipla Ltd.
Not yet recruiting – verified December 2015
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
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Emergency department staff may help identify, recruit at-risk patients for …
Healio Black patients with asthma may be more likely to participate in online asthma prevention activities if they are approached in the emergency department during an acute asthma event than by telephone are mail, according to results from a recent pilot study. |
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UCLA, USC partner on mHealth projects to help young asthma patients
FierceMobileHealthcare (press release) Scientists from University of California, Los Angeles, and the University of Southern California are embarking on a $6 million research effort to use smartphones and smartwatches to help young asthma sufferers improve thier health, according to an … App for Kids to ID Asthma Attack Triggers |
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'Iggy and the Inhalers': Doctors Take Creative Approach to Educate Patients …
NBCNews.com Broncho the Bronchodilator? Coltron the Controller? It's Iggy and the Inhalers to the rescue! When Dr. Alex Thomas noticed that children and their parents often struggled to understand asthma and sometimes confused the different types of medications … |
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Asthma Patients with Anxiety See More Severe Symptoms
Pharmacy Times “Anxiety sensitivity amplifies your reaction to anxiety symptoms, which are very similar to asthma symptoms,” study author Alison C. McLeish, PhD, told Pharmacy Times. “We found that people with asthma and high anxiety symptoms were more reactive to … |
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