Relationship between Pesticide Metabolites, Cytokine Patterns, and Asthma-Related Outcomes in Rural Women Workers.

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Relationship between Pesticide Metabolites, Cytokine Patterns, and Asthma-Related Outcomes in Rural Women Workers.

Int J Environ Res Public Health. 2016;13(10)

Authors: Mwanga HH, Dalvie MA, Singh TS, Channa K, Jeebhay MF

Abstract
The objective of this study was to investigate the relationship between exposure to organophosphate (OP) and pyrethroid (PYR) pesticides with serum cytokine patterns and asthma-related outcomes among rural women workers. A cross-sectional study was conducted among rural women (n = 211), including those working and living on farms and nearby town dwellers. Pesticide exposure was assessed using urinary metabolite concentrations of OP and PYR pesticides. Health outcome assessment was ascertained through the European Community Respiratory Health Survey (ECRHS) questionnaire, fractional exhaled nitric oxide (FeNO), and serum cytokines associated with asthma. The prevalence of doctor-diagnosed asthma was 11%, adult-onset asthma 9%, and current asthma 6%. In this population, the proportion of T helper type 2 (Th2) cytokines (interleukin (IL)-4, IL-5, and IL-13) detectable in subjects was between 18% and 40%, while the proportion of non-Th2 cytokines (IL-6, IL-8, IL-10, IL-17, and interferon gamma) was between 35% and 71%. Most Th2 and non-Th2 cytokines were positively associated with either OP or PYR metabolites. Non-Th2 cytokines showed much stronger associations with OP metabolites (Dimethyl phosphate OR = 4.23; 95% CI: 1.54-11.65) than Th2 cytokines (Dimethyl phosphate OR = 1.69; 95% CI: 0.83-3.46). This study suggests that exposure to most OP and some PYR pesticides may be associated with asthma-related cytokines, with non-Th2 cytokines demonstrating consistently stronger relationships.

PMID: 27690066 [PubMed – as supplied by publisher]

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New approaches to qualitative interviewing: Development of a card sort technique to understand subjective patterns of symptoms and responses.

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New approaches to qualitative interviewing: Development of a card sort technique to understand subjective patterns of symptoms and responses.

Int J Nurs Stud. 2016 Jan 9;

Authors: Mammen JR, Norton SA, Rhee H, Butz AM

Abstract
BACKGROUND: Ability to elicit individuals’ perceptions of complex behavioral processes can be challenging, as it hinges not only upon the skill of the researcher, but also upon assumptions of a shared language and individuals’ ability to recall, analyze, and effectively communicate events. In a case-based qualitative-descriptive study about teens’ experiences of asthma self-management, we found that variations in terminology and descriptions of events, symptoms, and responses made it difficult to understand teens’ experiences of asthma. In particular, teens’ conceptualization of their asthma symptoms and self-management responses differed from situation to situation, from other teens in the study, from the interviewer, and from prior reports in the literature. These differences across many levels made it difficult to identify patterns in individual processes of self-management, and among teens in general..
OBJECTIVES: To address these challenges, we developed a card sorting activity to facilitate in-depth exploration of teens’ experiences of asthma.
DESIGN: Case-based qualitative description.
SETTING: Teen-parent dyads (N=28) were recruited from the community, Emergency Department, Pediatric Pulmonary Department, and prior study subjects of a major medical center.
METHODS: Teens first identified and then sequenced their own unique sets of asthma symptoms and self-management responses. Teens then developed contextually grounded narratives using the card sort they had created as a visual aid.
RESULTS: This technique not only allowed us to bridge teen-interviewer communication barriers and develop shared terminology, but also resulted in a visible sequence of asthma symptoms and self-management responses.
CONCLUSIONS: The card sort technique facilitated researcher-teen discussion and enabled comparison of self-management patterns across teens in our study. This technique is potentially useful for other areas of research exploring behavioral processes with complex and individual-specific experiences, in particular those involving sequences of events and self-management responses. This paper delineates the development, utility, and potential applications of the symptom-response card sorting technique for research and clinical practice.

PMID: 26897540 [PubMed – as supplied by publisher]

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Association between Dietary Patterns and Atopic Dermatitis in Relation to GSTM1 and GSTT1 Polymorphisms in Young Children.

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Association between Dietary Patterns and Atopic Dermatitis in Relation to GSTM1 and GSTT1 Polymorphisms in Young Children.

Nutrients. 2015;7(11):9440-9452

Authors: Chung J, Kwon SO, Ahn H, Hwang H, Hong SJ, Oh SY

Abstract
Previous research suggests the association of glutathione S-transferase (GST) gene polymorphisms or diet, but no interactions between these factors in atopic dermatitis (AD). We conducted a community-based case-control study including 194 AD and 244 matched non-AD preschoolers. Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) present/null genotypes were evaluated uisng a multiplex PCR method. We measured dietary intakes by a validated food frequency questionnaire and constructed three dietary patterns such as “traditional healthy”, “animal foods”, and “sweets” diets. In stratified analyses by GST genotypes, the “traditional healthy” diet and reduced AD showed association only in the GSTM1-present group (odd ratio (OR) 0.31, 95% confidence interval (CI) 0.13-0.75). A similar pattern of the association existed in the combined GSTM1/T1 genotype that indicated the inverse association between the “traditional healthy” diet and AD in the double GSTM1/T1-present genotype group (OR 0.24, 95% CI 0.06-0.93). Results from the multiplicative test analyses showed that the “traditional healthy” diet on reduced AD was significant or borderline significant in the GSTM1-present group (OR 0.71, 95% CI 0.54-0.92 vs. GSTM1-null group) or the GSTM1/T1 double present group (OR 0.63, 95% CI 0.39-1.03 vs. GSTM1/T1 double null group). These findings demonstrate that the present type of GSTM1 may increase susceptibility to the potential effect of the “traditional healthy” diet on AD.

PMID: 26580648 [PubMed – as supplied by publisher]

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Program maps patterns of asthma varieties – Pittsburgh Post-Gazette – Pittsburgh Post Gazette

Program maps patterns of asthma varieties – Pittsburgh Post-Gazette
Pittsburgh Post Gazette
Asthma isn't just one disease but comes in up to six different varieties, according to a new computer analysis from Carnegie Mellon University and the University of Pittsburgh Asthma Institute at UPMC. The study confirms several subtypes of the disease

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Temporal Asthma Patterns Using Repeated Questionnaires over 13 Years in a Large French Cohort of Women.

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Temporal Asthma Patterns Using Repeated Questionnaires over 13 Years in a Large French Cohort of Women.

PLoS One. 2013;8(5):e65090

Authors: Sanchez M, Bousquet J, Le Moual N, Jacquemin B, Clavel-Chapelon F, Humbert M, Kauffmann F, Tubert-Bitter P, Varraso R

Abstract
Variable expression is one aspect of the heterogeneity of asthma. We aimed to define a variable pattern, which is relevant in general health epidemiological cohorts. Our objectives were to assess whether: 1) asthma patterns defined using simple asthma questions through repeated measurements could reflect disease variability 2) these patterns may further be classified according to asthma severity/control. Among 70,428 French women, we used seven questionnaires (1992-2005) and a comprehensive reimbursement database (2004-2009) to define three reliable asthma patterns based on repeated positive answers to the ever asthma attack question: “never asthma” (n?=?64,061); “inconsistent” (“yes” followed by “no”, n?=?3,514); “consistent” (fully consistent positive answers, n?=?2,853). The “Inconsistent” pattern was related to both long-term (childhood-onset asthma with remission in adulthood) and short-term (reported asthma attack in the last 12 months, associated with asthma medication) asthma variability, showing that repeated questions are relevant markers of the variable expression of asthma. Furthermore, in this pattern, the number of positive responses (1992-2005) predicted asthma drug consumption in subsequent years, a marker of disease severity. The “Inconsistent” pattern is a phenotype that may capture the variable expression of asthma. Repeated answers, even to a simple question, are too often neglected.

PMID: 23741466 [PubMed – in process]

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Local virus patterns may affect kids’ asthma risk, study says – Lansing State Journal


MedPage Today

Local virus patterns may affect kids' asthma risk, study says
Lansing State Journal
Infants in urban areas have different patterns of viral respiratory illness than those in the suburbs, which may explain why inner-city children are more likely to develop asthma, a new study suggests. The findings may lead to new ways to treat
Inner-City Kids Get Different Kinds of ColdsMedPage Today
Inner City Infants Have Different Patterns of Viral Respiratory Illness Than Infection Control Today
Expat Health Insurance News: Virus infections 'linked to higher rates of Expatriate Healthcare
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Inner City Infants Have Different Patterns of Viral Respiratory Illness Than … – Infection Control Today

Inner City Infants Have Different Patterns of Viral Respiratory Illness Than
Infection Control Today
Children living in low-income urban areas appear especially prone to developing asthma, possibly related to infections they acquire early in life. In a new study in the Journal of Infectious Diseases, researchers from the University of Wisconsin in

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Virus Patterns Where Kids Live May Affect Asthma Risk – U.S. News & World Report

Virus Patterns Where Kids Live May Affect Asthma Risk
U.S. News & World Report
WEDNESDAY, Sept. 26 (HealthDay News) — Infants in urban areas have different patterns of viral respiratory illness than those in the suburbs, which may explain why inner-city children are more likely to develop asthma, a new study suggests. The
Inner city infants have different patterns of viral respiratory illness than Science Codex

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