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IBM, Georgia Institute of Technology form pediatric data partnership
ZDNet (blog) This effort, dubbed One Million Healthy Children, will focus on children with diabetes, asthma and autism fist. The project includes Emory University, Children's Healthcare of Atlanta, Georgia Cancer Coalition and the Georgia Department of Community … IBM and Georgia Institute of Technology Partner on "One Million Healthy … |
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 MD News (press release) |
Pediatric Asthma Drug Prescriptions on the Upswing
MD News (press release) Among children, the use of medications to control asthma nearly doubled in the last decade, while costs associated with all asthma medications more than quadrupled, according to a September statistical brief published by the Agency for Healthcare … |
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Children with asthma, colds less likely to respond to medications
Pediatric SuperSite With the respiratory infection season now in full swing, parents should consider more intense monitoring of their children who have asthma, as these children may be less likely to respond to asthma medications if they have a cold, according to a study … |
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Preterm birth potential risk factor for asthma
Pediatric SuperSite Preterm birth may be a risk factor for asthma later in life, according to a study published online this week. Neera K. Goyal, MD, of The Children's Hospital of Philadelphia, and colleagues conducted a retrospective cohort study that used electronic … |
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Fifty years of pediatric asthma in developed countries: How reliable are the basic data sources?
Pediatr Pulmonol. 2011 Sep 8;
Authors: Chawla J, Seear M, Zhang T, Smith A, Carleton B
Abstract
Given the difficulties in diagnosing, or even defining, asthma in children, claims of a pediatric asthma epidemic in Canada and other developed countries are accepted with surprisingly little critical examination. We reviewed a broad range of data sources to understand how the epidemic evolved during the last 50 years and also to assess the reliability of the conclusions drawn from that data. We obtained Canadian National and Provincial data from Statistics Canada National Population Health Survey, and the British Columbia Ministry of Health respiratory database. International data were obtained by extensive review of pediatric asthma epidemiological surveys published during the last 50 years. In many developed countries, there have been three separate epidemics involving different aspects of pediatric asthma during the last 50 years: a double peaked mortality epidemic (1960s and 1980s), a hospital admission epidemic (peaked around 1990) and a steadily growing epidemic of children who report asthmatic symptoms on questionnaires. Canadian pediatric rates for asthma mortality (1-2/million/year) and hospital admission (1-2/thousand/year) are low and have fallen for the last 20 years. Rates based on questionnaire studies are high (10-15/hundred) and rose steadily over the same period. Objective reductions in asthma deaths and hospital admission likely reflect improved education and treatment programmes. Current claims of an epidemic based largely on subjective self-reported symptoms require more careful analysis. The possibility that symptom misperception, disease fashions, and poor recall, may be part of the explanation for the current high levels of self-reported symptoms deserves more attention. Pediatr Pulmonol. © 2011 Wiley-Liss, Inc.
PMID: 21905263 [PubMed – as supplied by publisher]
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Beta-adrenergic receptor polymorphisms associated with length of ICU stay in pediatric status asthmaticus.
Pediatr Pulmonol. 2011 Sep 8;
Authors: Carroll CL, Sala KA, Zucker AR, Schramm CM
Abstract
BACKGROUND: During severe exacerbations, asthmatic children vary significantly in their response to high-dose continuous ?(2) -adrenergic receptor (ADR?(2) ) agonist therapy. Genetic polymorphisms have been identified within the ADR?(2) that may be functionally relevant, but few studies have been performed in this population. Our hypothesis was that genotypic differences are associated with magnitude of response to ADR?(2) agonist treatment during severe asthma exacerbations in children. METHODS: Children aged 2-18 years admitted to the ICU (intensive care unit) with a severe asthma exacerbation between 2006 and 2008 were eligible. Genotyping of the ADR?(2) was performed. RESULTS: Eighty-nine children consented and were enrolled. Despite similar clinical asthma scores on admission, children with the Gly(16) Gly genotype at amino acid position 16 had significantly shorter ICU length of stay (LOS) and hospital LOS, compared to children with Arg(16) Arg and Arg(16) Gly genotypes. Children with either the Gln(27) Glu or Glu(27) Glu genotype at amino acid position 27 also had significantly shorter ICU LOS and hospital LOS compared to children with the Gln(27) Gln genotype. The Arg(16) Gly-Gln(27) Gln haplotype was associated with the longest ICU LOS, but this was not statistically different from other haplotypes. CONCLUSIONS: In this cohort of children with severe asthma exacerbations, ADR?(2) polymorphisms were associated with responses to therapy. Knowledge of the genetic profile of children with asthma may allow for targeted therapy during acute exacerbations. Pediatr Pulmonol. © 2011 Wiley-Liss, Inc.
PMID: 21905268 [PubMed – as supplied by publisher]
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Children with asthma may benefit from vitamin C
Pediatric SuperSite Certain children with asthma may experience a reduction in symptoms with the help of vitamin C, according to a results of a new study. Younger children with mild asthma symptoms appeared to have the greatest benefit, while older children with more … |
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Indoor air cleaner helped reduce asthma symptoms in children living with smokers
Pediatric SuperSite Air cleaners can greatly reduce air pollution and lower the rates of daytime asthma symptoms in children living in households with one or more smokers, according to a study. “Use of air cleaners in homes of children with asthma was associated with a … |
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 Press TV |
Early mold exposure may play role in asthma development
Pediatric SuperSite Early life exposure to mold may play a role in childhood asthma development, according to a study published online. Tiina Reponen, PhD, professor of environmental health at the University of Cincinnati, and colleagues analyzed 7 years of data for 176 … Mold exposure in infancy raises asthma |
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Consortium identifies asthma gene in certain ethnicities
Pediatric SuperSite By pooling data from nine independent research groups looking for genes associated with asthma, the EVE Consortium has identified a novel gene association specific to populations of African descent. In addition, the study confirmed the significance of … Got Asthma? It Might be your DNA |
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