Breathe Well Live Well
|
Project Establishes Distinct Asthma Phenotypes
MedPage Today A new report, unveiled at the European Respiratory Society International Congress 2015, identifies the signature characteristics of asthma patients with frequent exacerbations compared with those with more indolent disease, along with a taxonomy of … |
View full post on asthma – Google News
|
Phenotypes of severe asthma among children and adolescents in Brazil: a …
BMC Blogs Network Background The morbidity associated with severe uncontrolled asthma is disproportionately higher in low- and middle-income countries than in high-income countries. The aim of this study was to describe the phenotypic characteristics of difficult-to … |
View full post on asthma – Google News
| Related Articles |
Emerging Molecular Phenotypes of Asthma.
Am J Physiol Lung Cell Mol Physiol. 2014 Oct 17;
Authors: Ray A, Oriss TB, Wenzel SE
Abstract
Although asthma has long been considered a heterogeneous disease, attempts to define subgroups of asthma have been limited. In recent years both clinical and statistical approaches have been utilized to better merge clinical characteristics, biology and genetics. These combined characteristics have been used to define “phenotypes” of asthma, the observable characteristics of a patient determined by the interaction of genes and environment. Identification of consistent clinical phenotypes has been reported across studies. Now the addition of various ‘omics and identification of specific molecular pathways has moved the concept of clinical phenotypes towards the concept of molecular phenotypes. The importance of these molecular phenotypes is being confirmed through the integration of molecularly targeted biologic therapies. Thus, the term global asthma is poised to become obsolete, being replaced by terms which more specifically identify the pathology associated with the disease.
PMID: 25326577 [PubMed – as supplied by publisher]
View full post on pubmed: asthma
|
Physiological variables best predict adult asthma phenotypes
News-Medical.net Physiological variables are more consistent predictors of adult asthma phenotypes than inflammatory biomarkers, an international team of researchers suggests. Using data from the Pan-European BIOAIR study, the team found that patients' phenotypes were … |
View full post on asthma – Google News
|
Physiological variables best predict adult asthma phenotypes
medwireNews medwireNews: Physiological variables are more consistent predictors of adult asthma phenotypes than inflammatory biomarkers, an international team of researchers suggests. Using data from the Pan-European BIOAIR study, the team found that patients' … |
View full post on asthma – Google News
|
Polyclonal cytokine profiles differentiated asthma phenotypes
Healio Young adults with allergic asthma demonstrated a TH2-polarized cytokine response after polyclonal stimulation, suggesting that allergic and nonallergic asthma can be differentiated by specific immune endotypes, according to researchers. Edward Zoratti … |
View full post on asthma – Google News
Condition: Persistent Asthma
Intervention: Other: electronic nose
Sponsors: Fundació Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau; Astrid Crespo
Completed – verified December 2013
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
|
Inflammatory phenotypes underlying uncontrolled childhood asthma despite …
7thSpace Interactive (press release) The diagnosis of childhood asthma covers a broad spectrum of pathological mechanisms that can lead to similarly presenting clinical symptoms, but may nonetheless require different treatment approaches. Distinct underlying inflammatory patterns are … |
View full post on asthma – Google News
 Family Practice News Digital Network |
Adult Phenotypes No Help in Severe Pediatric Asthma
Family Practice News Digital Network Adult asthma phenotypes offer little guidance in the identification and management of severe, therapy-resistant asthma in children. Recent efforts to replicate the findings in severe pediatric asthma, however, met with disappointing results, … |
View full post on asthma – Google News
Risk factors for current wheezing and its phenotypes among elementary school children.
Pediatr Pulmonol. 2011 Feb;46(2):166-174
Authors: Civelek E, Cakir B, Orhan F, Yuksel H, Boz AB, Uner A, Sekerel BE
BACKGROUND: Accumulating evidence suggests, asthma includes many phenotypes with varying clinical and prognostic features. Epidemiological surveys documented a number of environmental risk factors for the development of asthma and interestingly these differ between and within countries, suggesting that the differences may be related with the different distribution of asthma phenotypes. This study aimed to investigate risk factors of current wheezing (CW) and different wheezing phenotypes in elementary school children. METHODS: Six thousand nine hundred sixty-three 9- to 11-year-old children of a previous multicenter survey where the methodology of the International Study of Asthma and Allergies in Childhood (ISAAC) Phase-II was used were analyzed. Wheezing phenotypes were defined as wheezing with rhinitis (RW), wheezing with rhinoconjunctivitis (RCW), atopic wheezing (AW), non-atopic wheezing (NAW), and frequent wheezing (FW) (?4/year wheezing episodes). RESULTS: The prevalence of CW was 15.8% and among these, 22.4%, 67.3%, 45.9%, 20.5%, and 79.5% were classified as FW, RW, RCW, AW, and NAW, respectively. History of parental asthma/allergic rhinitis, coexistence of other allergic diseases, presence of mold and dampness in the house lived during the first year of life and maternal smoking in pregnancy were found to be risk factors for most phenotypes (odds ratio (OR) ranged from 1.43 to 3.56). Number of household in the last year (OR?=?1.14), prematurity (OR?=?2.08), and duration of breastfeeding (OR?=?1.02) per additional month were found to be risk factor for FW, AW, and RCW, respectively. CONCLUSION: Beside common risk factors for the development of asthma and its phenotypes, certain risk factors appeared to play a role in the development of phenotypic characteristics of asthma. These findings support our hypothesis that each phenotype has not only different clinical characteristics but also has different roots. Pediatr. Pulmonol. 2011; 46:166-174. © 2011 Wiley-Liss, Inc.
PMID: 21290615 [PubMed – as supplied by publisher]
View full post on pubmed: asthma