Early Pneumonia Telltale Predictor for Asthma Later in Life – Medscape

Early Pneumonia Telltale Predictor for Asthma Later in Life
Medscape
Children who experienced lower respiratory illnesses during the first 3 years of their life had diminished lung function impairment as adults, and those who suffered from pneumonia as young children were at nearly twice the risk of having asthma and
Early pneumonia linked with later asthma and wheezeFamily Practice News Digital Network

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Risk factors for a poor outcome among children admitted with clinically severe pneumonia to a university hospital in Rabat, Morocco.

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Risk factors for a poor outcome among children admitted with clinically severe pneumonia to a university hospital in Rabat, Morocco.

Int J Infect Dis. 2014 Oct 8;

Authors: Jroundi I, Mahraoui C, Benmessaoud R, Moraleda C, Tligui H, Seffar M, Kettani SE, Benjelloun BS, Chaacho S, Muñoz-Almagro C, Ruiz J, Alonso PL, Bassat Q

Abstract
OBJECTIVES: Data on prognostic factors among children with severe pneumonia are scarce in middle-income countries. We investigated prognostic factors for an adverse outcome among children admitted to the Hôpital d’Enfants de Rabat, Morocco with World Health Organization-defined clinically severe pneumonia (CSP).
METHODS: Children aged 2-59 months admitted to the hospital and fulfilling the CSP definition were recruited into this 13-month prospective study. A poor prognosis was defined as death, a need for intensive care, or a Respiratory Index of Severity in Children (RISC) score ?3. Multivariate logistic regression was performed to ascertain independent predictive factors for a poor prognosis.
RESULTS: Of the 689 children included in this analysis, 55 (8.0%) required intensive care and 28 died (4.0%). Five hundred and two (72.8%) children were classified as having a good prognosis and 187 (27.2%) as having a poor prognosis. A history of prematurity (odds ratio (OR) 2.50, 95% confidence interval (CI) 1.24-5.04), of fever (OR 2.25, 95% CI 1.32-3.83), living in a house with smokers (OR 1.79, 95% CI 1.18-2.72), impaired consciousness (OR 10.96, 95% CI 2.88-41.73), cyanosis (OR 2.09, 95% CI 1.05-4.15), pallor (OR 2.27, 95% CI 1.34-3.84), having rhonchi on auscultation (OR 2.45, 95% CI 1.58-3.79), and human metapneumovirus infection (OR 2.13, 95% CI 1.13-4.02) were all independent risk factors for an adverse outcome, whereas a history of asthma (OR 0.46, 95% CI 0.25-0.84) was the only independent risk factor for a positive outcome.
CONCLUSIONS: The early identification of factors associated with a poor prognosis could improve management strategies and the likelihood of survival of Moroccan children with severe pneumonia.

PMID: 25305555 [PubMed – as supplied by publisher]

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Is your shift likely to give you asthma or pneumonia? – TheHealthSite


TheHealthSite

Is your shift likely to give you asthma or pneumonia?
TheHealthSite
asthma-diagnosis A research has found that drugs widely used to treat lung diseases like asthma or pneumonia work better with the body clock. Once the ancient rhythm of our body clock is disturbed owing to artificial light, shift work and jet lag
Researchers Explain why Asthma, Pneumonia Drugs Become Ineffective Over Nature World News
Asthma and pneumonia drugs work with the body clockFinancial Express

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Researchers Explain why Asthma, Pneumonia Drugs Become Ineffective Over … – Nature World News


Nature World News

Researchers Explain why Asthma, Pneumonia Drugs Become Ineffective Over
Nature World News
Drugs used to treat asthma and pneumonia tend to work with the body's clock, a new study has found. The research explains why these drugs become ineffective over time. Both asthma and pneumonia cause inflammation of the lung airways. The study …
Drugs used to treat lung disease work with the body clockMedical Xpress
'Body clock' impacts on lung disease treatmentsThe Conversation

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Predictive value of C-reactive protein in response to macrolides in children with macrolide-resistant Mycoplasma pneumoniae pneumonia.

Predictive value of C-reactive protein in response to macrolides in children with macrolide-resistant Mycoplasma pneumoniae pneumonia.

Korean J Pediatr. 2014 Apr;57(4):186-92

Authors: Seo YH, Kim JS, Seo SC, Seo WH, Yoo Y, Song DJ, Choung JT

Abstract
PURPOSE: The prevalence of macrolide-resistant Mycoplasma pneumoniae (MRMP) has increased worldwide. The aim of this study was to estimate the proportion of MRMP in a tertiary hospital in Korea, and to find potential laboratory markers that could be used to predict the efficacy of macrolides in children with MRMP pneumonia.
METHODS: A total of 95 patients with M. pneumoniae pneumonia were enrolled in this study. Detection of MRMP was based on the results of specific point mutations in domain V of the 23S rRNA gene. The medical records of these patients were reviewed retrospectively and the clinical course and laboratory data were compared.
RESULTS: The proportion of patients with MRMP was 51.6% and all MRMP isolates had the A2063G point mutation. The MRMP group had longer hospital stay and febrile period after initiation of macrolides. The levels of serum C-reactive protein (CRP) and interleukin-18 in nasopharyngeal aspirate were significantly higher in patients who did not respond to macrolide treatment. CRP was the only significant factor in predicting the efficacy of macrolides in patients with MRMP pneumonia. The area under the curve for CRP was 0.69 in receiver operating characteristic curve analysis, indicating reasonable discriminative power, and the optimal cutoff value was 40.7 mg/L.
CONCLUSION: The proportion of patients with MRMP was high, suggesting that the prevalence of MRMP is rising rapidly in Korea. Serum CRP could be a useful marker for predicting the efficacy of macrolides and helping clinicians make better clinical decisions in children with MRMP pneumonia.

PMID: 24868216 [PubMed]

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HIM Frontman Diagnosed With ‘Severe Asthma With Presumptive Pneumonia … – BLABBERMOUTH.NET


BLABBERMOUTH.NET

HIM Frontman Diagnosed With 'Severe Asthma With Presumptive Pneumonia
BLABBERMOUTH.NET
"HIM's North American tour (which was due to kick off in Los Angeles on May 3rd at the House Of Blues) has been cancelled due to unforeseen medical circumstances. HIM's lead vocalist Ville Valo has been diagnosed with severe asthma with presumptive

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Cinnamon challenge: Pneumonia, asthma attacks possible from inhaling … – Examiner.com


Examiner.com

Cinnamon challenge: Pneumonia, asthma attacks possible from inhaling
Examiner.com
Doing the cinnamon challenge can lead to pneumonia and asthma attacks, the Los Angeles Times reported April 22. In the cinnamon challenge, which seems especially appealing to youngsters, someone ingests a tablespoon of cinnamon powder without
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Pediatricians: Just say no to "cinnamon challenge"Main Line
Counsel & Heal –WTMA –Smithsonian (blog)
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