Condition: Asthma
Intervention:
Sponsor: AstraZeneca
Not yet recruiting – verified May 2014
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
One-Third of Greenpoint’s Vulnerable Population Report Asthma in Households – DNAinfo
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One-Third of Greenpoint's Vulnerable Population Report Asthma in Households
DNAinfo “The study confirms what North Brooklyn residents have known for ages: That asthma rates in North Brooklyn are alarmingly high, largely because of our neighborhood's disproportionate concentration of waste transfer stations and the consequent truck … |
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Up to 6% of Lebanon’s population has Asthma – AME Info
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Up to 6% of Lebanon's population has Asthma
AME Info According to recent studies in Lebanon, current levels of asthma control in the country fall far short of goals specified in international guidelines for asthma management, with allergic diseases exhibiting high prevalence and catching up with rates of … |
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GWAS IDs New Atopic Dermatitis Risk Loci in Japanese Population – GenomeWeb
 Science Codex |
GWAS IDs New Atopic Dermatitis Risk Loci in Japanese Population
GenomeWeb "These findings suggest that atopic dermatitis and asthma or allergic rhinitis have overlapping susceptibility regions," senior author Mayumi Tamari, a respiratory diseases researcher at the Riken Center, and co-authors wrote, "and that these regions … 8 new susceptibility loci for eczema identified Japanese Scientists Identify DNA That Causes Skin Disease |
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Nocturnal gastroesophageal reflux, asthma and symptoms of obstructive sleep apnoea: a longitudinal, general population study.
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Nocturnal gastroesophageal reflux, asthma and symptoms of obstructive sleep apnoea: a longitudinal, general population study.
Eur Respir J. 2012 Sep 27;
Authors: Emilsson OI, Bengtsson A, Franklin KA, Torén K, Benediktsdóttir B, Farkhooy A, Weyler J, Dom S, Backer WD, Gislason T, Janson C
Abstract
Nocturnal gastroesophageal reflux (nGER) is associated with asthma and obstructive sleep apnoea (OSA). Our aim was to investigate whether nGER is a risk factor for onset of asthma and onset of respiratory and OSA symptoms in a prospective population based study.We invited 2640 subjects from Iceland, Sweden and Belgium for two evaluations over a nine years interval. They participated in structured interviews, answered questionnaires, underwent spirometries and methacholine challenge testing. nGER was defined by reported symptoms.Subjects with persistent nGER (n=123) had an independent increased risk of new asthma at follow-up [OR (95% CI): 2.3 (1.1-4.9)]. Persistent nGER was independently related to onset of respiratory symptoms [OR (95% CI): 3.0 (1.6-5.6)]. The risk of developing symptoms of OSA was increased in subjects with new and persistent nGER [OR (95% CI): 2.2 (1.3-1.6) and 2.0 (1.0-3.7), respectively]. No significant association was found between nGER and lung function or bronchial responsiveness.Persistent symptoms of nocturnal gastroesophageal reflux contributes to the development of asthma and respiratory symptoms. New onset of OSA symptoms is higher among subjects with symptoms of nGER. These findings support that nGER may play a role in the genesis of respiratory symptoms and diseases.
PMID: 23018910 [PubMed – as supplied by publisher]
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Allergies, Asthma Lower in Amish Population – ABC News
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Allergies, Asthma Lower in Amish Population
ABC News Procedure claims to take years off your body from head to toe in a doctor visit. |
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Watch: Allergies, Asthma Lower in Amish Population
New study suggests life on northern Indiana farms boosts immunity.
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Relationship between air pollution, NFE2L2 gene polymorphisms and childhood asthma in a Hungarian population.
Relationship between air pollution, NFE2L2 gene polymorphisms and childhood asthma in a Hungarian population.
J Community Genet. 2011 Dec 30;
Authors: Ungvári I, Hadadi E, Virág V, Nagy A, Kiss A, Kalmár A, Zsigmond G, Semsei AF, Falus A, Szalai C
Abstract
Air pollution and subsequent increased oxidative stress have long been recognized as contributing factors for asthma phenotypes. Individual susceptibility to oxidative stress is determined by genetic variations of the antioxidant defence system. In this study, we analysed the association between environmental nitrogen dioxide (NO(2)) exposure and single nucleotide polymorphisms (SNP) in NFE2L2 and KEAP1 genes and their common impact on asthma risk. We genotyped 12 SNPs in a case-control study of 307 patients diagnosed with asthma and 344 controls. NO(2) concentration was collected from the period preceding the development of asthma symptoms. Multiple logistic regression was applied to evaluate the effects of the studied genetic variations on asthma outcomes in interaction with NO(2) exposure. Our data showed that genotypes of rs2588882 and rs6721961 in the regulatory regions of the NFE2L2 gene were inversely associated with infection-induced asthma (odds ratio (OR)?=?0.290, p?=?0.0015, and OR?=?0.437, p?=?0.007, respectively). Furthermore, case-only analyses revealed significant differences for these SNPs between asthma patients that lived in modestly or highly polluted environment (OR?=?0.43 (0.23-0.82), p?=?0.01, and OR?=?0.51, p?=?0.02, respectively, in a dominant model). In conclusion, our results throw some new light upon the impact of NFE2L2 polymorphisms on infection-induced asthma risk and their effect in gene-environment interactions.
PMID: 22207565 [PubMed – as supplied by publisher]
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9/11 Responders Suffer Asthma Rates Twice as High as the General Population – EHS Today
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9/11 Responders Suffer Asthma Rates Twice as High as the General Population
EHS Today 11, 2001, face asthma rates that double those of the general population, according to new research. The study, published online Nov. 8 in the American Journal of Industrial Medicine, reveals that exposure to the toxic dust from the towers' collapse has … |
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Asthma exacerbation and proximity of residence to major roads: a population … – 7thSpace Interactive (press release)
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Asthma exacerbation and proximity of residence to major roads: a population …
7thSpace Interactive (press release) The relationship between asthma and traffic-related pollutants has received considerable attention. The use of individual-level exposure measures, such as residence location or proximity to emission sources, may avoid ecological biases. … |
View full post on asthma – Google News