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Back to School With Confidence: Prevent Bullying of Kids With Asthma, Food …
MarketWatch 19, 2014 /PRNewswire-USNewswire/ — Children with asthma and food allergies are vulnerable to bullying at school and online, often by classmates who tease or harass them because they're "different." It may be an age-old problem, but it must be … Study finds food allergies are more common in inner-city children Urban Youth May Have Heightened Food Allergy Risk |
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CXCR4 Antagonism as a Therapeutic Approach to Prevent Acute Kidney Injury.
Am J Physiol Renal Physiol. 2014 Jul 30;
Authors: Zuk A, Gershenovich M, Ivanova Y, MacFarland RT, Fricker SP, Ledbetter SR
Abstract
We examined whether antagonism of the CXCR4 receptor ameliorates the loss of renal function following ischemia-reperfusion. CXCR4 is ubiquitously expressed on leukocytes, known mediators of renal injury, and on bone marrow hematopoietic stem cells (HSC). Plerixafor (AMD3100, Mozobil ) is a small molecule CXCR4 antagonist that mobilizes HSCs into the peripheral blood and also modulates the immune response in in vivo rodent models of asthma and rheumatoid arthritis. Treatment with plerixafor before and after ischemic clamping ameliorated kidney injury in a rat model of bilateral renal ischemia-reperfusion. Serum creatinine and blood urea nitrogen were significantly reduced 24 hours after reperfusion, as was tissue injury and cell death. Plerixafor prevented the renal increase in the pro-inflammatory chemokines CXCL1 and CXCL5 and the cytokine IL-6. Flow cytometry of kidney homogenates confirmed the presence of significantly fewer leukocytes with plerixafor treatment; additionally, myeloperoxidase activity was reduced. AMD3465, a monocyclam analogue of AMD3100, was likewise renoprotective. Four weeks post-reperfusion, long-term effects included diminished fibrosis, inflammation and ongoing renal injury. The mechanism by which CXCR4 inhibition ameliorates AKI is due to modulation of leukocyte infiltration and expression of pro-inflammatory chemokines/cytokines, rather than a HSC mediated effect. The data suggest that CXCR4 antagonism with plerixafor may be a potential option to prevent AKI.
PMID: 25080523 [PubMed – as supplied by publisher]
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Parents Can Prevent Asthma Attacks
Seaside Courier (NAPSI)—Seven million children in the United States have asthma and more than half of them will experience an asthma attack this year, according to the Centers for Disease Control and Prevention (CDC)—but a few simple steps can make a difference. |
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Parents Can Prevent Asthma Attacks
ScoopSanDiego.com (NAPSI)—Seven million children in the United States have asthma and more than half of them will experience an asthma attack this year, according to the Centers for Disease Control and Prevention (CDC)—but a few simple steps can make a difference. |
View full post on asthma – Google News
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Early Exposure to Dirt, Dander Could Prevent Allergies, Asthma
Voice of America Exposure to pet dander, roach droppings and other household bacteria in the first year of life appears to reduce the chances a person will suffer from allergies or asthma, according to a new study. Researchers at Johns Hopkins Children's Center found … |
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UPI.com |
New synthetic molecule can help prevent asthma attacks triggered by allergens
Tech Times (Photo : Wikimedia Commons). Millions of Americans suffer from asthma, a chronic lung condition characterized by tightness on the chest, breathlessness, wheezing and coughing whenever the sufferer is exposed to certain allergens. A study conducted by a … Researchers discover molecule that could treat allergen-induced asthma Synthetic molecule thwarts asthma symptoms Researchers Discover Novel Molecule to Treat Asthma |
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Daily Mail |
Exposing newborn babies to germs could prevent them suffering from asthma as …
Daily Mail Around 1,250 Britons die from asthma every year and mortality rate is the third highest in Europe, behind only Estonia and Spain. Figures show that 1.1 million children in the UK suffer from asthma (picture posed by a model). The latest figures … Mothers told, stick to soap and water with newborns |
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Economic Times |
Education and early medication can prevent Asthma attacks: Doctors
Economic Times As per a WHO report on World Asthma Day, the fundamental cause of asthma, that is characterised by recurrent attacks of breathlessness and wheezing is not completely understood, but the strongest risk factors for developing asthma include indoor … Poll campaign speeches lead to asthma attacks |
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Could a Common Asthma Drug Prevent MS?
Healthline A common drug used to treat asthma may protect against multiple sclerosis (MS), according to new research findings. Fenoterol, a bronchodilator used to open the airways, may hold the key. A little more than a decade ago, scientists believed that … |
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Condition: Post-ERCP Acute Pancreatitis
Interventions: Drug: Rectal Indomethacin; Drug: Epinephrine
Sponsors: Johns Hopkins University; American Society for Gastrointestinal Endoscopy; Asian Institute of Gastroenterology, India; Postgraduate Institute of Medical Education and Research; Apollo Gleneagles Hospitals, India
Not yet recruiting – verified April 2014
View full post on ClinicalTrials.gov: asthma | received in the last 14 days