Gene mutations in primary ciliary dyskinesia related to otitis media.

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Gene mutations in primary ciliary dyskinesia related to otitis media.

Curr Allergy Asthma Rep. 2014 Mar;14(3):420

Authors: Mata M, Milian L, Armengot M, Carda C

Abstract
Otitis media with effusion (OME) is the most common cause of conductive hearing loss in children and is strongly associated with primary ciliary dyskinesia (PCD). Approximately half of the children with PCD require otolaryngology care, posing a major problem in this population. Early diagnosis of PCD is critical in these patients to minimise the collateral damage related to OME. The current gold standard for PCD diagnosis requires determining ciliary structure defects by transmission electron microscopy (TEM) or clearly documenting ciliary dysfunction via digital high-speed video microscopy (DHSV). Although both techniques are useful for PCD diagnosis, they have limitations and need to be supported by new methodologies, including genetic analysis of genes related to PCD. In this article, we review classical and recently associated mutations related to ciliary alterations leading to PCD, which can be useful for early diagnosis of the disease and subsequent early management of OME.

PMID: 24459089 [PubMed – in process]

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The Academy of Allergy & Asthma in Primary Care and United Allergy Services … – Sacramento Bee

The Academy of Allergy & Asthma in Primary Care and United Allergy Services
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The Academy of Allergy & Asthma in Primary Care and United Allergy Services … – PR Newswire (press release)

The Academy of Allergy & Asthma in Primary Care and United Allergy Services
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WASHINGTON and SAN ANTONIO, Jan. 14, 2014 /PRNewswire/ — The Academy of Allergy & Asthma in Primary Care (AAAPC)™, a nation-wide, non-profit organization that represents the interests of primary care physicians whose practice includes allergy 
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AEROCRINE AB : Aerocrine: First Primary Care Trial Supports FeNO-Guided … – 4-traders (press release)

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Academy of Allergy & Asthma in Primary Care Provides a Voice for PCPs for
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Using a knowledge translation framework to implement asthma clinical practice guidelines in primary care.

Using a knowledge translation framework to implement asthma clinical practice guidelines in primary care.

Int J Qual Health Care. 2012 Aug 14;

Authors: Licskai C, Sands T, Ong M, Paolatto L, Nicoletti I

Abstract
Quality problemInternational guidelines establish evidence-based standards for asthma care; however, recommendations are often not implemented and many patients do not meet control targets.Initial assessmentRegional pilot data demonstrated a knowledge-to-practice gap.Choice of solutionsWe engineered health system change in a multi-step approach described by the Canadian Institutes of Health Research knowledge translation framework.ImplementationKnowledge translation occurred at multiple levels: patient, practice and local health system. A regional administrative infrastructure and inter-disciplinary care teams were developed. The key project deliverable was a guideline-based interdisciplinary asthma management program. Six community organizations, 33 primary care physicians and 519 patients participated. The program operating cost was $290/patient.EvaluationSix guideline-based care elements were implemented, including spirometry measurement, asthma controller therapy, a written self-management action plan and general asthma education, including the inhaler device technique, role of medications and environmental control strategies in 93, 95, 86, 100, 97 and 87% of patients, respectively. Of the total patients 66% were adults, 61% were female, the mean age was 35.7 (SD = ±24.2) years. At baseline 42% had two or more symptoms beyond acceptable limits vs. 17% (P< 0.001) post-intervention; 71% reported urgent/emergent healthcare visits at baseline (2.94 visits/year) vs. 45% (1.45 visits/year) (P< 0.001); 39% reported absenteeism (5.0 days/year) vs. 19% (3.0 days/year) (P< 0.001). The mean follow-up interval was 22 (SD = ±7) months.Lessons learnedA knowledge-translation framework can guide multi-level organizational change, facilitate asthma guideline implementation, and improve health outcomes in community primary care practices. Program costs are similar to those of diabetes programs. Program savings offset costs in a ratio of 2.1:1.

PMID: 22893665 [PubMed – as supplied by publisher]

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